Results 121 to 130 of about 1,233,492 (271)

Helicobacter pylori induces the production of interleukin-37 to promote broad immunosuppression and enhance colonization

Gut Microbes
Helicobacter pylori infects approximately half of the world’s population, resulting in lifelong gastric infections. To promote lifelong colonization, H. pylori modulates host immunity via unknown mechanisms. Here we show that H.
Rishi Pathirana, Nagaja Capitani, Christopher McCrory, Chiara Della Bella, Isabella Stuart, William Gilmore, Natalie J. Bitto, Michelle D. Tate, Ella L. Johnston, Lauren Zavan, Steven Batinovic, John Pedersen, Sam Norden, Hassan Chaudhry, Richard L. Ferrero, Tony M. Korman, David Greening, Neil O’Brien-Simpson, Andrew M. Ellisdon, James C. Whisstock, Steve Petrovski, Renea A. Taylor, Mario M. D’Elios, Claudia A. Nold-Petry, Marcel F. Nold, Maria Kaparakis-Liaskos   +25 more
doaj   +1 more source

Case studies of job access and reverse commute program: 2009-2010 [PDF]

, 2011
This report presents perceptual, mobility and employment outcomes self-reported by 573 users of 26 transportation services funded by the Job Access and Reverse Commute (JARC) program.
Blaise, E.T., Cottrill, C., Soot, S., Thakuriah, P., Tilahun, N., Vassilakis, W.   +5 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The dynamics and optimal control of spinning spacecraft with movable telescoping appendages. Part C: Effect of flexibility during boom deployment [PDF]

The dynamics of a spinning symmetrical spacecraft system during the deployment (or retraction) of flexible boom-type appendages were investigated. The effect of flexibility during boom deployment is treated by modelling the deployable members as compound
Bainum, P. M., James, P. K.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Circulating Interleukin-37 as a Biomarker Candidate for Hepatocellular Carcinoma in Decompensated Advanced Chronic Liver Disease

Life
Hepatocellular carcinoma (HCC) remains a leading cause of mortality in patients with advanced chronic liver disease (ACLD), particularly in those with decompensated cirrhosis, where traditional biomarkers such as alpha-fetoprotein (AFP) often fail to ...
Michael Mederer, Johanna Piater, Felix Keller, Barbara Enrich, Veronika Cibulkova, Valeria Wagner, Rebecca Giquel-Fernandes, Andreas Kronbichler, Herbert Tilg, Maria Effenberger   +9 more
doaj   +1 more source

Thermal fatigue and oxidation data of TAZ-8A and M22 alloys and variations [PDF]

Thermal fatigue and oxidation data were obtained on 36 specimens, representing 18 distinct variations (including the base systems) of TAZ-8A and M22 alloys.
Hofer, K. E., Humphreys, V. E.
core   +1 more source

IL-37 linked to gout pathogenesis and treatment [PDF]

Nature Reviews Rheumatology, 2020
openaire   +2 more sources