Results 121 to 130 of about 5,184,526 (265)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Helicobacter pylori induces the production of interleukin-37 to promote broad immunosuppression and enhance colonization

Gut Microbes
Helicobacter pylori infects approximately half of the world’s population, resulting in lifelong gastric infections. To promote lifelong colonization, H. pylori modulates host immunity via unknown mechanisms. Here we show that H.
Rishi Pathirana, Nagaja Capitani, Christopher McCrory, Chiara Della Bella, Isabella Stuart, William Gilmore, Natalie J. Bitto, Michelle D. Tate, Ella L. Johnston, Lauren Zavan, Steven Batinovic, John Pedersen, Sam Norden, Hassan Chaudhry, Richard L. Ferrero, Tony M. Korman, David Greening, Neil O’Brien-Simpson, Andrew M. Ellisdon, James C. Whisstock, Steve Petrovski, Renea A. Taylor, Mario M. D’Elios, Claudia A. Nold-Petry, Marcel F. Nold, Maria Kaparakis-Liaskos   +25 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Study of Down Regulation IL-37 Expression in Breast Cancer Tumoral Tissues and its Association with Tumoral Grade 3

مجله علمی دانشگاه علوم پزشکی کردستان, 2018
Background and Aim: Nowadays, breast cancer is the most common cancer among women in the world. Considering the high prevalence, identification of diagnostic markers can be useful for early diagnosis and cancer management.
Marzieh Ghafari Farsani, Somayeh Reiisi, Maryam peymani   +2 more
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

محیی الدین شیخ محمد چلبی سلطان (MS 36); مناقب برهان الدین افندی (MS 37)

Birbirinden farklı 2 adet yazmanın bir araya getirilmesiyle oluşturulmuş ve ciltlenmiş bir eserdir (Yazma numaraları : MS 36, MS 37). MS 36 : Eser, Eğridir’de Zeyniyye tarikatını kuran Pir Mehmed-i Hoyî’nin oğlu Muhyiddin mahlaslı Şeyh Mehmed Çelebi ...
Muhyid-din Şeyh Mehmed Çelebi Sultan b. eş-Şeyh Pir Mehmed-i Hoyi Egridiri / محیی الدین شیخ محمد چلبی سلطان (MS 36); Unidentified (MS 37)
core  

IL-37 protects against obesity-induced inflammation and insulin resistance

, 2015
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the development of systemic insulin resistance. Here, we report that IL-37, a newly-described antiinflammatory member of the IL-1 family, affects obesity-induced ...
van Diepen, Janna A., Muller, Michael, Boekschoten, Mark, Stienstra, Rinke, Ballak, Dov B., Kersten, Sander   +5 more
core   +1 more source