Results 111 to 120 of about 18,323,172 (295)

IL‐4/IL‐13 pathway in nasal type 2 inflammation: The central role and targeted therapy

Eye & ENT Research
Type 2 dominant inflammation in nasal mucosa is the key underlying pathophysiological mechanism of allergic rhinitis (AR) and most presentations of chronic rhinosinusitis with nasal polyps (CRSwNP).
Zhiqiu Zhu, Chaoran Zhao, Ming Wang
doaj   +1 more source

IgE Generation and Mast Cell Activation

European Journal of Inflammation, 2014
IgE is an important marker for allergy and plays a central role in the induction of allergic diseases through its binding of the high affinity receptor on mast cells. Mast cells can influence B cell survival, proliferation and differentiation into CD138 +
S.K. Kritas, A. Caraffa, P. Antinolfi, A. Saggini, A. Pantalone, G. Neri, M. Rosati, M. Tei, A. Speziali, R. Saggini, F. Pandolfi, G. Cerulli, P. Conti   +12 more
doaj   +1 more source

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]

, 2010
Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager, Brand, Stephan, Burkhard Göke, Göke, Burkhard, Artur Kaul, Stephan Brand, Beigel, Florian, Kaul, Artur, Kathrin Zitzmann, Helmut M. Diepolder, Diegelmann, Julia, Diepolder, Helmut M., Christoph J Auernhammer, Bartenschlager, Ralf, Helmut M Diepolder, Christoph J. Auernhammer, Julia Diegelmann, Florian Beigel, Zitzmann, Kathrin, Auernhammer, Christoph J.   +19 more
core   +1 more source

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

Frontiers in Immunology, 2018
Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells.
Ilkka S. Junttila, Ilkka S. Junttila
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]

, 2007
More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Stäubert, Claudia, Tarnow, Patrick, Pitra, Christian, Gudermann, T., Stäubert, C. ; https://orcid.org/, Tarnow, P., Brumm, H., Römpler, Holger, Grüters, A., Biebermann, H., Brumm, Harald, Pitra, C., Gudermann, Thomas, Biebermann, Heike, Schöneberg, T., Schöneberg, Torsten, Römpler, H., Grüters, Annette   +17 more
core   +1 more source

Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis. [PDF]

Allergy, 2023
Avlas S, Shani G, Rhone N, Itan M, Dolitzky A, Hazut I, Grisaru-Tal S, Gordon Y, Shoda T, Ballaban A, Ben-Baruch NM, Rochman M, Diesendruck Y, Nahary L, Bitton A, Halpern Z, Benhar I, Varol C, Rothenberg ME, Munitz A.   +19 more
europepmc   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Cellular mechanisms and effects of IL-4 receptor blockade in experimental conjunctivitis evoked by skin inflammation. [PDF]

JCI Insight, 2023
Han H, Cummings S, Shade KC, Johnson J, Qian G, Gans J, Shankara S, Escobedo J, Zarazinski E, Bodinizzo R, Bangari D, Bryce P, Hicks A.   +12 more
europepmc   +1 more source