Results 121 to 130 of about 13,521,848 (335)

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. [PDF]

, 2018
Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in glioblastoma (GBM).
Brem, Steven, Dahmane, Nadia, Duan, Hao, Fan, Yi, Gong, Yanqing, He, Zhenqiang, Hidalgo, Juan, Huang, Menggui, Liu, Tianrun, Ma, Peihong, Mou, Yonggao, O'Rourke, Donald M, Wang, Qirui, Wang, Yanling, Xu, Haineng, Zamvil, Scott S, Zhang, Lin, Zhang, Zhenfeng   +17 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling

EBioMedicine, 2015
Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue.
Huang-Ming Cao, Xiao-Ping Ye, Jun-Hua Ma, He Jiang, Sheng-Xian Li, Rong-Ying Li, Xue-Song Li, Cui-Cui Guo, Zhi-Quan Wang, Ming Zhan, Chun-Lin Zuo, Chun-Ming Pan, Shuang-Xia Zhao, Cui-Xia Zheng, Huai-Dong Song   +14 more
doaj   +1 more source

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

Scientific Reports, 2018
We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are ...
A. Ng, W. Tam, M. Zhang, Cyrus S. H. Ho, S. F. Husain, R. McIntyre, R. Ho   +6 more
semanticscholar   +1 more source

Inflammatory and angiogenic protein detection in the human vitreous : cytometric bead assay [PDF]

, 2011
Introduction. To evaluate clinical feasibility and reproducibility of cytometric bead assay (CBA) in nondiluted vitreous samples of patients with age-related macular degeneration (ARMD), diabetic macular edema (DME), and central retinal vein occlusion ...
Koch, Frank H., Koss, Michael Janusz, Pfister, Marcel   +2 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Choroidal Neovascular Membrane in Age-Related Macular Degeneration is Associated with Increased Interleukin-6

International Journal of Gerontology, 2012
Background: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment and blindness among persons aged 60 years and older.
Zuhal Yildirim, Nil Irem Ucgun, Filiz Yildirim, Aylin Sepici-Dincel   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles

Life
Allergic conjunctivitis is one of the common immune hypersensitivity disorders that affect the ocular system. The clinical manifestations of this condition exhibit variability contingent upon environmental factors, seasonal dynamics, and genetic ...
DeGaulle I. Chigbu, Nicholas J. Karbach, Sampson L. Abu, Navpreet K. Hehar   +3 more
doaj   +1 more source

Targeting IL-6 trans-signalling: past, present and future prospects

Nature reviews. Immunology, 2023
S. Rose-John, B. Jenkins, Christoph Garbers, Jens M. Moll, J. Scheller   +4 more
semanticscholar   +1 more source