Results 241 to 250 of about 14,944,976 (275)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Development of Bispecific Antibody Targeting Human IL-17A and IL-6. [PDF]

Antibodies (Basel)
Pamuła B, Banach M, Mikońska M, Korytkowska K, Lacek K, Śniadała O, Marczak M, Flis K, Sowińska A, Kołakowski D, Pieczykolan J, Zygmunt B, Wieczorek M, Abramczyk O.   +13 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Blood IL-6 is a critical trigger of depressive symptoms in a mouse model for human atopic dermatitis. [PDF]

Transl Psychiatry
Matsuda K, Muko R, Moon C, Shin T, Arkwright PD, Pennock JL, Endo S, Yanai S, Jensen-Jarolim E, Shibuya A, Tominaga M, Takamori K, Oikawa MA, Tanaka A, Matsuda H.   +14 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

IL-6 trans-signaling: an overlooked driver of retinal neovascularization? [PDF]

Angiogenesis
Jung M, Ness JN, Schwämmle ME, Rapp J, Boneva S, Groß O, Mitschke J, Schlunck G, Agostini H, Hannibal L, Bucher F.   +10 more
europepmc   +1 more source

GDA-Pred: Generative AI-Driven Data Augmentation for Improved Prediction of IL-6 and IL-13-Inducing Peptides. [PDF]

Int J Mol Sci
Kurata H, Tsuruta H, Shigetomi S, Harun-Or-Roshid M, Maeda K.   +4 more
europepmc   +1 more source

Enhanced mRNA Expression of Colonic IL-6 in Cronkhite-Canada Syndrome Bearing Colorectal Cancer. [PDF]

In Vivo
Fujihara D, Honjo H, Masuta Y, Otsuka Y, Masaki S, Minaga K, Kamata K, Tsuji N, Watanabe T, Kudo M.   +9 more
europepmc   +1 more source

DCLK1 regulates stemness and IL-6/STAT3-dependent metastatic niche formation in chemoresistant ovarian cancer. [PDF]

J Exp Clin Cancer Res
Dogra S, Elayapillai SP, Hladik C, Hasan A, Das M, Mortan LF, Qu D, Houchen CW, Hannafon BN.   +8 more
europepmc   +1 more source

The Preventive Effect of Introducing Glutamine on Chemotherapy-Induced Diarrhea in Colorectal Cancer and Its Influence on Inflammatory Factors Such as CRP and IL-6. [PDF]

Mol Nutr Food Res
Zhu J, Liu Y.
europepmc   +1 more source