Results 291 to 300 of about 13,521,848 (335)
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A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors.
Bioorganic & Medicinal Chemistry, 2020Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates its biological roles through a hexameric complex composed of IL-6 itself, its
Sukhvir Kaur +3 more
semanticscholar +1 more source
IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy.
Cellular Immunology, 2020Myeloid-derived suppressor cells (MDSC) are generated during tumor progression and suppress the anti-tumor functions of T and natural killer (NK) cells.
Rebekka Weber +7 more
semanticscholar +1 more source
Analysis of interleukin 6 (IL-6)/IL-6 receptor system using monoclonal anti-IL-6 antibodies
Molecular Immunology, 1991To investigate the IL-6/IL-6 receptor system, we obtained five murine monoclonal antibodies against human IL-6, which neutralize its biological activity. We classified them into two groups (Type I mAb and Type II mAb) according to the epitopes they recognized. These two types of antibodies showed no difference in the manner in which they neutralized IL-
T, Shimamura +5 more
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Journal of Biological Regulators and Homeostatic Agents, 2020
COVID-19 (coronavirus disease-19) involves humans as well as animals and may cause serious damage to the respiratory tract including the lung. This pathogenic virus has been identified in swabs performed on the throat and nose of patients who suffer from
P. Conti +6 more
semanticscholar +1 more source
COVID-19 (coronavirus disease-19) involves humans as well as animals and may cause serious damage to the respiratory tract including the lung. This pathogenic virus has been identified in swabs performed on the throat and nose of patients who suffer from
P. Conti +6 more
semanticscholar +1 more source
TNF-α and IL-6: the link between immune and bone system.
Current Drug Targets, 2020Osteoimmunology is a new subject which focuses on the communication between the immune and the skeletal systems. Both the immune system and bone communicate with each other.
Tiantian Wang, Chengqi He
semanticscholar +1 more source
IL-6 drives hepatocyte dedifferentiation
Science Signaling, 2023Injury-induced hepatocyte reprogramming depends on a proinflammatory cytokine from Kupffer cells.
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Neuroscience, 2013
Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and repetitive behavior and restricted interests. Emerging evidence suggests that aberrant neuroimmune responses may contribute to phenotypic deficits and could be appropriate targets for pharmacologic ...
H, Wei, I, Alberts, X, Li
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Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and repetitive behavior and restricted interests. Emerging evidence suggests that aberrant neuroimmune responses may contribute to phenotypic deficits and could be appropriate targets for pharmacologic ...
H, Wei, I, Alberts, X, Li
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IL-6 receptor expression and IL-6 effects change during osteoblast differentiation
Cytokine, 2008Studies of the effects of interleukin-6 on osteoblasts have yielded conflicting results. In several earlier in vitro studies it has been stated that IL-6 has no effects on osteoblasts unless soluble IL-6 receptor is added. These results are contradictory to the fact that IL-6 receptors are expressed in osteoblasts in vivo.
Yan, Li +3 more
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cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
Nature, 2022Christy Hong +16 more
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