Results 301 to 310 of about 13,521,848 (335)

[IL-6 blockade].

Nihon rinsho. Japanese journal of clinical medicine, 2016
Interleukin-6 (IL-6) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Tocilizumab, anti-human IL-6 receptor monoclonal antibody developed in Japan, prevents IL-6 from binding to IL-6 receptor blocking IL-6 signal. The clinical and radiographic efficacy of tocilizumab has proved in many clinical studies.
Yuko, Kaneko, Tsutomu, Takeuchi
openaire   +1 more source

IL-6-regulated transcription factors

The International Journal of Biochemistry & Cell Biology, 1997
Through the cloning of two transcription factors named NF-IL6 and STAT3/APRF, two types of IL-6 signal transduction pathways from the cell surface to the nucleus have been revealed. NF-IL6 is phosphorylated and activated by a Ras-dependent MAP kinase cascade, while STAT3/APRF is directly tyrosine-phosphorylated by JAK kinases that associate with the ...
openaire   +2 more sources

IL-6 and Crohns Disease

Current Drug Target -Inflammation & Allergy, 2003
Interleukin-6 (IL-6) is a pleiotropic cytokine with central roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M.
openaire   +2 more sources

IL-6 as a keystone cytokine in health and disease

Nature Immunology, 2015
C. Hunter, Simon A. Jones
semanticscholar   +1 more source

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

Nature Medicine, 2018
M. Norelli, B. Camisa, G. Barbiera, Laura Falcone, Ayurzana Purevdorj, M. Genua, F. Sanvito, M. Ponzoni, C. Doglioni, P. Cristofori, C. Traversari, C. Bordignon, F. Ciceri, Renato Ostuni, C. Bonini, M. Casucci, A. Bondanza   +16 more
semanticscholar   +1 more source

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

Psychosomatic Medicine, 2009
M. Howren, D. Lamkin, J. Suls
semanticscholar   +1 more source

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Nature Immunology, 2007
Liang Zhou, I. Ivanov, R. Spolski, Roy Min, K. Shenderov, Takeshi Egawa, D. Levy, W. Leonard, D. Littman   +8 more
semanticscholar   +1 more source

Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies.

, 2020
P. Conti, P. Conti, G. Ronconi, A. Caraffa, C. Gallenga, R. Ross, I. Frydas, S. Kritas   +7 more
semanticscholar   +1 more source

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Nature reviews. Immunology, 2018
Simon A. Jones, B. Jenkins
semanticscholar   +1 more source

IL-6

2006
  +4 more sources