Results 31 to 40 of about 1,576,668 (338)

Inter-α-Inhibitor Impairs TSG-6-Induced Hyaluronan Cross-Linking [PDF]

, 2013
Under inflammatory conditions and in the matrix of the cumulus-oocyte complex (COC), the polysaccharide hyaluronan (HA) becomes decorated covalently with heavy chains (HCs) of the serum glycoprotein inter-α-inhibitor (IαI).
Briggs, David C., Richter, Ralf P., Day, Anthony J., Ralf P. Richter, Baranova, Natalia, Viranga Tilakaratna, Day, Anthony J.; id_orcid, David C. Briggs, Natalia S. Baranova, Tilakaratna, Viranga, Enghild, Jan J., Caroline M. Milner, Baranova, Natalia S., Jan J. Enghild, Milner, Caroline M., Foulcer, Simon J., Simon J. Foulcer, Anthony J. Day   +17 more
core   +1 more source

Atypical course of COVID-19 in patient with Bruton agammaglobulinemia

Journal of Infection in Developing Countries, 2020
We present atypical course of the novel coronavirus disease (COVID-19) in 34-year man with Bruton agammaglobulinemia. The patient was successfully treated by a combination of available drugs, including convalescent plasma and interleukin-6 (IL-6 ...
Ivana Milošević, Jaroslava Jovanović, Olja Stevanovic   +2 more
doaj   +1 more source

Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines

Frontiers in Molecular Neuroscience, 2022
Our previous studies have clarified that red nucleus (RN) interleukin (IL)-6 is involved in the maintenance of neuropathic pain and produces a facilitatory effect by activating JAK2/STAT3 and ERK pathways.
Qing-Qing Yang, Qing-Qing Yang, Hao-Nan Li, Yu-Tong Xia, Xue Tian, Fan Feng, Jian Yang, Ya-Li Xu, Juan Guo, Xiao-Qi Li, Jun-Yang Wang, Xiao-Yan Zeng   +11 more
doaj   +1 more source

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Cytokine release syndrome (CRS) is a life-threatening complication induced by hyperinflammatory responses. However, no specific immunotherapies are available for its treatment.
Sujin Kang, Toshio Tanaka, H. Inoue, C. Ono, S. Hashimoto, Y. Kioi, Hisatake Matsumoto, H. Matsuura, Tsunehiro Matsubara, Kentarou Shimizu, H. Ogura, Y. Matsuura, T. Kishimoto   +12 more
semanticscholar   +1 more source

Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells

Journal of Neuroinflammation, 2011
Background Peripheral-type benzodiazepine receptor (PBR) expression levels are low in normal human brain, but their levels increase in inflammation, brain injury, neurodegenerative states and gliomas.
Iida Hiroki, Kozawa Osamu, Tanabe Kumiko
doaj   +1 more source

Inhibition effect of curcumin on UVB-induced secretion of pro-inflammatory cytokines from corneal limbus epithelial cells [PDF]

International Journal of Ophthalmology, 2017
AIM: To study the effects of curcumin on the secretion of interleukin (IL) -6 and IL-8 by corneal limbus epithelial cells. METHODS: Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different ...
Shih-Chun Chao, Dan-Ning Hu, Joan Roberts, Xilun Shen, Chia-Yi Lee, Chan-Wei Nien, Hung-Yu Lin   +6 more
doaj   +1 more source

IL-27 regulates IL-18 binding protein in skin resident cells [PDF]

, 2012
IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Wittmann, M, Miriam Wittmann, Werfel, Thomas, Bachmann, M, Doble, Rosella, Muehl, H, Thomas Werfel, Doble Rosella, Pfeilschifter, Josef (Prof. Dr.), Doble, R, Heiko Mühl, Mühl Heiko, Malte Bachmann, Wittmann Miriam, Pfeilschifter, J, Wittmann, Miriam, Bachmann Malte, Werfel, T, Josef Pfeilschifter, Werfel Thomas, Bachmann, Malte, Mühl, Heiko, Rosella Doble, Pfeilschifter Josef   +23 more
core   +1 more source

AA amyloidosis – Benefits and prospects of IL-6 inhibitors [PDF]

Modern Rheumatology, 2018
AA amyloidosis may develop in patients with active chronic inflammation. Serum amyloid A (SAA), the precursor of the AA protein, is strongly amplified in the liver under the stimulation of inflammation-associated cytokines, such as IL-6, TNF, and IL-1.
openaire   +2 more sources

Erratum: Actemra poised to launch IL-6 inhibitors [PDF]

Nature Biotechnology, 2008
Nat. Biotechnol. 26, 957–959 (2008); published online 7 November 2008; corrected after print 5 December 2008 In the version of this article initially published, on p. 958, right-hand column, line 2, it was incorrectly stated that Rituxan is used for treating multiple sclerosis: “Rituxan (rituximab),a B cell–depleting biologic for treating rheumatoid ...
Lisa Melton, Amy Coombs
openaire   +1 more source

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]

, 2002
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Dolmans, Wil M.V., van der Meer, Jos W. M., Wil Dolmans, Setiati, T.E., Dolmans, W.M.V., C. Hack, Jos van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Djokomoeljanto, R.J., Cate, H. ten, Djokomoeljanto, Robert J., Cate, Hugo ten, Suharti, C., Catharina Suharti, Djokomoeljanto, Robert J., Gorp, E. van, Meer, J.W.M. van der, Dolmans, Wil M. V., Setiati, Tatty E., Meer, Jos W.M. van der, Eric van Gorp, Napel, C.H.H. ten, Gorp , Eric C.M. van, ten, Cate Hugo, Suharti, Catharina, Setiati , Tatty E., Robert Djokomoeljanto, Gorp, E.C.M. van, van Gorp, Eric C. M., Tatty Setiati   +31 more
core   +1 more source