Results 41 to 50 of about 1,576,668 (338)

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]

, 2000
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ, Rajko Reljic (406091), Rajko Reljic, Reljic, R, Fearon, DT, Simon D. Wagner, Luke J. Peakman, Luke J. Peakman (7768292), Fearon, D T, Douglas T. Fearon, Wagner, S D, Wagner, SD, Simon D. Wagner (7633943), Douglas T. Fearon (7768295), Peakman, L J   +14 more
core   +1 more source

Favorable clinical response and drug retention of anti-IL-6 receptor inhibitor in rheumatoid arthritis with high CRP levels: the ANSWER cohort study

, 2021
Currently, biological disease-modifying anti-rheumatic drugs (bDMARDs) with different modes of action [tumour necrosis factor inhibitor (TNFi), interleukin-6 receptor inhibitor (IL-6Ri), or cytotoxic T-lymphocyte antigen 4–immunoglobulin (CTLA4-Ig)] are ...
K Ohmura (5804036), R Watanabe (11424821), K Murata (11424824), H Ito (1401829), Y Hiramatsu (11424833), K Akashi (11424836), M Tanaka (46344), Y Nakayama (11424818), K Murakami (6338000), H Amuro (6952040), A Onishi (11424839), K Yamamoto (7725152), S Matsuda (1401838), M Hashimoto (1401844), W Yamamoto (5804033), R Hara (11424842), A Morinobu (11424845), K Hata (11424830), M Katayama (7391966), Y Son (6952046), K Ebina (11424827)   +20 more
core   +1 more source

A benefit and the prospects of IL-6 inhibitors in idiopathic multicentric Castleman's disease [PDF]

Modern Rheumatology, 2019
Castleman's disease (CD), a heterogeneous group of lymphoproliferative disorders, is divided into unicentric CD (UCD) and multicentric CD (MCD) based on the number of regions of enlarged lymph nodes with characteristic histopathologic features. The clinical pictures and treatment differ greatly between these UCD and MCD.
Tomohiro, Koga, Remi, Sumiyoshi, Atsushi, Kawakami, Kazuyuki, Yoshizaki   +3 more
openaire   +2 more sources

Heterotrimeric G Protein Gα13-Induced Induction of Cytokine mRNAs Through Two Distinct Pathways in Cardiac Fibroblasts

Journal of Pharmacological Sciences, 2006
.: Overexpression of constitutively active (CA)-Gα13 significantly increased the expression of interleukin (IL)-1β and IL-6 mRNAs and proteins in rat cardiac fibroblasts.
Nagamatsu Yuichi, Nishida Motohiro, Onohara Naoya, Fukutomi Masashi, Maruyama Yoshiko, Kobayashi Hiroyuki, Sato Yoji, Kurose Hitoshi   +7 more
doaj   +1 more source

Immunoregulatory Role of MicroRNA-21 in Macrophages in Response to Bacillus Calmette-Guerin Infection Involves Modulation of the TLR4/MyD88 Signaling Pathway

Cellular Physiology and Biochemistry, 2017
Background/Aims: The purpose of this study is to explore the immunoregulatory role of microRNA-21 (miR-21) targeting of the TLR4/MyD88 signaling pathway in macrophages in response to Bacillus Calmette-Guerin (BCG) infection. Methods: After infection with
Xin Xue, Yi Qiu, Hong-Li Yang
doaj   +1 more source

Potensi Pemberian Tocilizumab pada Pasien COVID-19 Di ICU RSUD Ulin Banjarmasin

JAI (Jurnal Anestesiologi Indonesia), 2020
Latar Belakang: Corona Virus Disease 2019 (COVID-19) adalah penyakit pandemi yang menjadi masalah global yang melanda seluruh dunia. Manifestasi klinis dan tingkat keparahan penyakit COVID-19 sangat bervariasi.
Rohmantuah Trada Purba, Mahendratama Purnama Adhi, Erna Kusumawardhani, Rapto Hardian, Andri Lumban Tobing   +4 more
doaj   +1 more source

Interleukin-1β promotes interleulin-6 expression via ERK1/2 signaling pathway in canine dermal fibroblasts.

PLoS ONE, 2019
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the immune response and inflammation. In this study, we investigated effect of the proinflammatory cytokine interleukin-1β (IL-1β) on IL-6 expression in canine dermal ...
Nanako Kitanaka, Rei Nakano, Kanae Sugiura, Taku Kitanaka, Shinichi Namba, Tadayoshi Konno, Tomohiro Nakayama, Hiroshi Sugiya   +7 more
doaj   +1 more source

A Synthesis of Novel Pyrazolylthienopyrimidine Derivatives as IL-6/STAT3 Inhibitors [PDF]

Bulletin of the Korean Chemical Society, 2014
The interleukin-6 (IL-6) as a pro-inflammatory cytokine with TNF-α and IL-8 plays a central role in the induction of inflammation as well as in the continuation of a chronic inflammatory immune response. And, an over-production of IL-6 have been found in inflammatory tissues of several diseases, such as rheumatoid arthritis, psoriasis, inflammatory ...
Sung Min Kim, Seung Woong Lee, Yang-Heon Song   +2 more
openaire   +1 more source

Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide (R) in isolated perfused rabbit hearts [PDF]

, 2008
The calpain inhibitor A-705253 and the Na(+)/H(+) exchange inhibitor Cariporide (R) were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first ...
Speth, Maria, Erdogan, Ali, Neuhof, Heinz, Neuhof, Christiane, Fabiunke, Verena, Fritz, Hans, Moeller, Achim, Tillmanns, Harald   +7 more
core   +1 more source

A rare case report: acute necrotizing encephalopathy and acute fulminant myocarditis

Frontiers in Cardiovascular Medicine
BackgroundAcute necrotizing encephalopathy (ANE) is a rare condition characterized by multiple symmetrical brain lesions mainly involving the thalamus. Acute fulminant myocarditis is a diffuse inflammatory disease of the myocardium characterized by acute
Juan Ma, Chenliang Pan, Nan Bai, Shanshan Zhang, Peiling Mi, Yongling Wa, Andong Lu   +6 more
doaj   +1 more source