Results 161 to 170 of about 80,028,732 (285)

Long-acting IL-7 restores T-cell reconstitution in a humanized mouse model of lymphopenia. [PDF]

J Allergy Clin Immunol
Pérez-Díez A, Liu X, Bennett A, Barrios M, Anderson M, Wolfarth AA, Choi D, Lisco A, Sereti I.   +8 more
europepmc   +1 more source

Interleukin-7 (IL-7) 발현 리포터 인간 세포주 확립 및 이를 활용한 IL-7 발현 유도 화학 물질 탐색

, 2017
Interleukin-7 (IL-7)은 T cell 항상성에 필수적인 cytokine 이며, 임상적으로도 중요하다. 하지만, IL-7 유전자 발현 조절 기전은 잘 알려진 바가 없고, IL-7 발현을 조절하는 화합물을 스크리닝 하기 위한 체계적인 방법이 아직 개발되어 있지 않다. 이번 연구에서는, CRISPR/Cas9을 이용한 유전자 편집 기술을 사용하여 인간 리포터 세포주(human reporter cell lines)를 제작하기 위한 시도를 하였다.
조연숙
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

IL-7: a potential next-generation adjuvant for immune cell therapies. [PDF]

Front Immunol
Hotchkiss RS, DiPersio JF, Yee C, Pachynski RK, Van Den Brink MRM.   +4 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Epigenetic Modulation of IL-7 and IL-10: Toward Personalized Immune Therapies in Viral Epidemics. [PDF]

J Immunol Res
Yulugkural Z, Yildiz M, Topcu E, Elmaslar Mert HT, Temiz A.   +4 more
europepmc   +1 more source

Il progetto e il monumento

, 2000
Presentazione del Convegno Internazionale " Il progetto e il monumento", IUAV, Istituto Gramsci, Fondazione Marotta. I giornata: Il monumento come questione della modernità.
MONTINI ZIMOLO, PATRIZIA, FABBRI, GIOVANNI BATTISTA   +1 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Long-acting IL-7 induces distinct transcriptomic features in peripheral T cells of patients with solid tumors. [PDF]

JCI Insight
Jang H, Kim JY, Kim S, Kim H, Byun MS, Lee MA, Chang JH, Nam DH, Kim TW, Jeun SS, Sohn JH, Park SH, Shin EC.   +12 more
europepmc   +1 more source