Results 181 to 190 of about 80,028,732 (285)

Immune dysregulation, apoptosis impairment, and enhanced seroreactivity to Anisakis simplex in Crohn's disease: interplay of IL-7/IL-7R signalling and CD132 deficiency [PDF]

Mem Inst Oswaldo Cruz
Cuéllar C, Hurtado-Marcos C, Valdivieso E, Vaccaro L, González-Fernández J, Jiménez AI, Pérez-Griera J, Benlloch S, Amorós C, Gil-Borrás R, Sorando-Serra R, Cano-Cano MJ, Andreu-Ballester JC.   +12 more
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Promoting the therapeutic potential of interleukin-7 (IL-7) by expression in viral vectors. [PDF]

Cancer Gene Ther
Hudson M, Newman RH, Rorie CJ, Holloman BL, Kaufman HL, Rabkin SD, Graves J, Saha D.   +7 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

CAR-T cells co-expressing IL-7 and CCL19 promote epitope spreading to enhance antitumor immunity. [PDF]

Cancer Immunol Immunother
Adachi K, Sakoda Y, Kaisho T, Tamada K.
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Translation factor eIF4G2 directs CD8⁺ T cell lineage commitment by selectively enabling the IL-7 receptor response. [PDF]

iScience
Cui J, Zhang X, Yang Y, Shan L, Li Y, Jiang L, Xie W, Jin T, Lang X.   +8 more
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

IL-7 in autoimmune diseases: mechanisms and therapeutic potential. [PDF]

Front Immunol
Zeng Z, Mao H, Lei Q, He Y.
europepmc   +1 more source