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A randomized, double-blind, placebo-controlled trial of IL-7 in critically ill patients with COVID-19. [PDF]
JCI InsightShankar-Hari M +24 more
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Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer. [PDF]
Commun BiolFiloni J +12 more
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The International Journal of Cell Cloning, 1990
Interleukin 7 (IL-7) is a cytokine initially referred to as pre-B cell growth factor because of its growth-promoting activity for cells early in the B lymphocyte lineage. Subsequent to IL-7 gene cloning and expression, IL-7 was also found to influence the activity of cells in the T lineage.
M B, Widmer +8 more
openaire +2 more sources
Interleukin 7 (IL-7) is a cytokine initially referred to as pre-B cell growth factor because of its growth-promoting activity for cells early in the B lymphocyte lineage. Subsequent to IL-7 gene cloning and expression, IL-7 was also found to influence the activity of cells in the T lineage.
M B, Widmer +8 more
openaire +2 more sources
Clinica Chimica Acta, 2011
Interleukin-7 (IL-7) is a growth and anti-apoptotic factor for T-lymphocytes, with potential for clinical use in the treatment of immunodeficiencies due to loss of T-cells. Lymphopenia induced by disease (HIV infection, hemodialysis or Idiopathic CD4+ lymphopenia) or by treatment (high dose chemotherapy or depleting antibodies) for cancer or auto ...
Frederique, Ponchel +2 more
openaire +2 more sources
Interleukin-7 (IL-7) is a growth and anti-apoptotic factor for T-lymphocytes, with potential for clinical use in the treatment of immunodeficiencies due to loss of T-cells. Lymphopenia induced by disease (HIV infection, hemodialysis or Idiopathic CD4+ lymphopenia) or by treatment (high dose chemotherapy or depleting antibodies) for cancer or auto ...
Frederique, Ponchel +2 more
openaire +2 more sources
The Journal of Immunology, 2012
Abstract Cytokine treatments are becoming increasingly popular clinical options. However, current methods of administration lack specificity and require massive doses to achieve biological effect. For IL-7 treatment, addition of a cytokine-neutralizing antibody paradoxically augments cytokine activity.
Chris Martin, Charles Surh
openaire +1 more source
Abstract Cytokine treatments are becoming increasingly popular clinical options. However, current methods of administration lack specificity and require massive doses to achieve biological effect. For IL-7 treatment, addition of a cytokine-neutralizing antibody paradoxically augments cytokine activity.
Chris Martin, Charles Surh
openaire +1 more source
B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.
The Journal of Immunology, 1994Abstract IL-7 was originally reported as a cytokine produced by stromal cells which supports pre-B cell proliferation in vitro. To determine whether human B cells secrete IL-7 and express IL-7R we studied a wide panel of B cell lines (CLS).
D, Benjamin +5 more
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Cellular Immunology, 2015
Many soluble cytokine receptors inhibit cytokine bioactivity, while others prolong ligand activity. The biological role of an endogenous soluble form of IL-7Rα, or its therapeutic effects on CD8(+) T-cells are unknown. We demonstrate that recombinant IL-7Rα-Fc, when pre-incubated with IL-7, enhances IL-7-induced CD8(+) T-cell proliferation and ...
Sandra, Côté +4 more
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Many soluble cytokine receptors inhibit cytokine bioactivity, while others prolong ligand activity. The biological role of an endogenous soluble form of IL-7Rα, or its therapeutic effects on CD8(+) T-cells are unknown. We demonstrate that recombinant IL-7Rα-Fc, when pre-incubated with IL-7, enhances IL-7-induced CD8(+) T-cell proliferation and ...
Sandra, Côté +4 more
openaire +2 more sources
Interleukin (IL)-7 Signaling in the Tumor Microenvironment
2021Interleukin (IL)-7 plays an important immunoregulatory role in different types of cells. Therefore, it attracts researcher's attention, but despite the fact, many aspects of its modulatory action, as well as other functionalities, are still poorly understood.
Iwona, Bednarz-Misa +2 more
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The key role of IL-7 in lymphopoiesis
Seminars in Immunology, 2012In mice, interleukin 7, although initially thought to be predominantly a cytokine acting on B cells, appears to have potent survival and growth activity during both B and T lymphopoiesis. Although acting on both lineages at the very immature stages, T cell differentiation becomes independent of IL-7 at the intermediate stages before regaining ...
Ceredig Rhodri, Rolink Antonius G
openaire +2 more sources