Results 11 to 20 of about 79,846,493 (299)

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours. [PDF]

Histology and histopathology, 2003
Interleukin-7 (IL-7) plays an important role in the normal development and maintenance of the human immune system. Its effects are mediated via its receptor, IL-7R. Ligand-receptor engagement results in a cascade of phosphorylation events mediated by various molecules including the Janus kinases (Jak1 and Jak3), PI3-kinase, Stats (signal transducers ...
Al-Rawi, M.A.A., Mansel, R.E., Jiang, W.G.   +2 more
openaire   +4 more sources

Il-7/Il-7 Receptor System Regulation following Il-2 Immunotherapy in HIV-Infected Patients

Antiviral Therapy, 2004
Interleukin-2 (IL-2) and IL-7 are the most intriguing molecules in immune-based HIV infection treatment. An in vitro IL-2/IL-7 cross-talk due to IL-2-driven IL-7 receptor-α-chain (IL-7Rα) down-modulation, potentially blocking IL-7 signalling has been described.
G. Marchetti, L. Meroni, C. Molteni, G. Taskaris, L. Gazzola, M. Galli, M. Clerici, M. Moroni, F. Franzetti, A. Gori   +9 more
core   +6 more sources

Rescue of Murine IL-7 Receptor Deficiency with Human IL-7 Receptor Gene Therapy

Blood, 2021
Abstract In humans, interleukin 7 (IL-7) receptor (IL-7R) deficiency causes approximately 10% of cases of severe combined immunodeficiency (SCID). IL-7R deficient SCID is a T-B+NK+ SCID and is caused by autosomal recessive deficiency of the IL-7R alpha chain gene (IL7R).
Michael Triebwasser, Danuta Jadwiga Jarocha, Laura Breda, Megan Fedorky, Stefano Rivella   +4 more
openaire   +1 more source

Differential Regulation of Human IL-7 Receptor α Expression by IL-7 and TCR Signaling [PDF]

The Journal of Immunology, 2008
Abstract IL-7Rα is essential for the development and homeostatic maintenance of mature T cells. Studies in humans and mice have shown that IL-7Rα expression is reduced by its cognate cytokine, IL-7, and Ag, suggesting that active regulation of IL-7 responsiveness is necessary to balance T cell numbers.
Alves, Nuno L., van Leeuwen, Ester M. M., Derks, Ingrid A. M., van Lier, René A. W.   +3 more
openaire   +3 more sources

Angiotensin-(1–7) attenuates SARS-CoV2 spike protein-induced interleukin-6 and interleukin-8 production in alveolar epithelial cells through activation of Mas receptor

Journal of Microbiology, Immunology and Infection, 2023
Background: SARS-CoV-2 spike proteins (SP) can bind to the human angiotensin-converting enzyme 2 (ACE2) in human pulmonary alveolar epithelial cells (HPAEpiC) and trigger an inflammatory process.
Yi-Luen Shen, Yi-An Hsieh, Po-Wei Hu, Po-Chun Lo, Yi-Han Hsiao, Hsin-Kuo Ko, Fang-Chi Lin, Chien-Wen Huang, Kang-Cheng Su, Diahn-Warng Perng   +9 more
doaj   +1 more source

An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells [PDF]

The Journal of Immunology, 2015
Abstract The IL-7R plays critical roles in lymphocyte development and homeostasis. Although IL-7R expression is strictly regulated during lymphocyte differentiation and the immune response, little is known regarding its in vivo regulation.
Akifumi, Abe, Shizue, Tani-ichi, Soichiro, Shitara, Guangwei, Cui, Hisataka, Yamada, Hitoshi, Miyachi, Satsuki, Kitano, Takahiro, Hara, Ryo, Abe, Yasunobu, Yoshikai, Koichi, Ikuta   +10 more
openaire   +2 more sources

Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer

Frontiers in Immunology, 2020
Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines within distinct branches of immunology. On one hand, TSLP is crucially important for mediating type 2 immunity at barrier surfaces and has been linked to widespread
Iva Marković, Iva Marković, Savvas N. Savvides, Savvas N. Savvides   +3 more
doaj   +1 more source

The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines

Frontiers in Immunology, 2021
Interleukin-7 (IL-7) is produced by stromal cells, keratinocytes, and epithelial cells in host tissues or tumors and exerts a wide range of immune effects mediated by the IL-7 receptor (IL-7R).
Juan Huang, Juan Huang, Juan Huang, Zhiyao Long, Zhiyao Long, Renyong Jia, Renyong Jia, Renyong Jia, Mingshu Wang, Mingshu Wang, Mingshu Wang, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Shun Chen, Shun Chen, Shun Chen, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Bin Tian, Bin Tian, Bin Tian, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Qun Gao, Qun Gao, Qun Gao, Anchun Cheng, Anchun Cheng, Anchun Cheng   +49 more
doaj   +1 more source

Characterization of lymphoid tissue inducer cells and lymphoid tissue development in adult interleukin 7 transgenic mice [PDF]

, 2008
During embryogenesis, the development of secondary lymphoid organs (SLOs) such as lymph nodes (LNs) and Peyer’s patches (PPs) requires the cellular crosstalk between vascular cell adhesion molecule (VCAM)-1+ mesenchymal organizer cells and CD45+CD4 ...
Schmutz, Sandrine
core   +1 more source

The human IL-7 receptor gene: deletions, polymorphisms and mutations. [PDF]

Semin Immunol, 2012
Most T cell subsets depend on IL-7 for survival. IL-7 binds to IL-7Rα and γc, initiating the signaling cascade. Deletion of IL-7Ra in humans has, for some time, been known to cause severe combined immunodeficiency. More recently, polymorphisms in IL-7R have been shown be a risk factor for a number of diseases that are autoimmune or involve excess ...
Mazzucchelli RI, Riva A, Durum SK.
europepmc   +5 more sources