Frontiers in Immunology, 2017 Interleukin-7 (IL-7), which is required for the development and survival of T cells in the thymus and periphery, plays a role in joint destruction. However, it remains unclear how IL-7 affects osteoclast formation.
Jin-Hee Kim +32 more
doaj +1 more source
Transcriptional Regulation of the Mouse IL-7 Receptor α Promoter by Glucocorticoid Receptor [PDF]
The Journal of Immunology, 2005 Abstract Expression of the IL-7R α-chain (IL-7Rα) is strictly regulated during the development and maturation of lymphocytes. Glucocorticoids (GC) have pleiotypic effects on the growth and function of lymphocytes. Although GC have been reported to induce the transcription of IL-7Rα gene in human T cells, its molecular mechanism is ...
Hai-Chon, Lee +4 more
openaire +2 more sources
Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. [PDF]
, 2010 Specific differences in signaling and antiviral properties between the different Lambda-interferons, a novel group of interferons composed of IL-28A, IL-28B and IL-29, are currently unknown.
Ralf Bartenschlager +28 more
core +1 more source
Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]
, 2001 An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Hoelzer, Dieter (Prof. Dr.) +15 more
core +1 more source
Innate immune signaling induces interleukin-7 production from salivary gland cells and accelerates the development of primary Sjögren's syndrome in a mouse model. [PDF]
PLoS ONE, 2013 Elevated IL-7 in the target tissues is closely associated with multiple autoimmune disorders, including Sjögren's syndrome (SS). We recently found that IL-7 plays an essential role in the development and onset of primary SS (pSS) in C57BL/6.NOD-Aec1Aec2 ...
Jun-O Jin, Yoshinori Shinohara, Qing Yu
doaj +1 more source
In vitro maintaining of CD4+ central and effector memory cells in normal and inflammatory conditions
Медицинская иммунология, 2020 IL-7 is a key factor for the survival and maintenance of CD4+ central (Tcm) and effector (Tem) memory cells in the whole body. In many autoimmune diseases, an elevated level of IL-7 is detected in blood serum and at the site of inflammation, thus ...
E. A. Blinova +3 more
doaj +1 more source
Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]
, 2010 Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M. +8 more
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Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line. [PDF]
The Journal of experimental medicine, 1990 A murine cell line (IxN/2b) absolutely dependent upon exogenous IL-7 for continued growth has been obtained that expresses lymphoid precursor and class I MHC antigens and also contains a rearranged mu heavy chain. This cell line has been used to define the binding and structural characteristics of the murine IL-7 receptor using 125I-labeled recombinant
L S, Park +4 more
openaire +2 more sources
Flip the coin: IL-7 and IL-7R in health and disease [PDF]
, 2019 The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells.
Benedict Seddon +8 more
core +1 more source
7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor.
PLoS ONE, 2017 We investigated effects of 7-oxygenated cholesterol derivatives present in atherosclerotic lesions, 7α-hydroxycholesterol (7αOHChol), 7β-hydroxycholesterol (7βOHChol), and 7-ketocholesterol (7K), on IL-8 expression.
Hyok-Rae Cho +6 more
doaj +1 more source