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IL-7R Expression Correlates with Prognosis in Breast Cancer
Combinatorial Chemistry & High Throughput ScreeningBackground: The tumor microenvironment (TME) exerts a significant influence on the development, invasion, metastasis, and drug resistance of breast cancer. Therefore, this study sought to investigate potential prognostic factors and markers indicative of TME remodeling in breast cancer, utilizing data from the TCGA database.
Xiaojie, Yu +5 more
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IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia
Advances in Biological Regulation, 2013Interleukin-7 (IL-7), a cytokine produced in the bone marrow, thymus and other organs, is mandatory for normal human T-cell development and peripheral homeostasis. Different studies, including phase I clinical trials, have indicated the potential therapeutic value of recombinant IL-7 in the context of anti-cancer immunotherapy and as a booster of ...
Ribeiro, Daniel +2 more
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NEW PATHOGENIC VARIANT ON IL-7R GENE ASSOCIATED WITH SCID
Annals of Allergy, Asthma & Immunology, 2018Introduction T-B+NK+ Severe Combined Immunodeficiency (SCID) due to mutations in the genes encoding the IL-7 receptor represent about 10% of American SCID cases. We report a patient found to have a c.675C>A (p.Tyr225*) homozygous mutation in exon 5.
J. Grossman, J. Shliozberg
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IL-7R and c-Kit signaling in thymopoiesis
2015IL-7 and Kit ligand (KL) are cytokines produced by thymic epithelial cells, which interact with their cognate receptors on immature thymocytes. The IL-7R is comprised of the IL-7R? and common ? chain (?c) and has no intrinsic kinase activity, while KL binds to the receptor tyrosine kinase Kit.
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EXPLORING IL-7R-ALPHA DEVELOPMENTAL EFFECTS AND ONCOGENIC COLLABORATIONS
2017Acute lymphoblastic leukemia is the most common cancer of children. Individual cases of leukemia may have multiple genetic lesions, and identifying those that drive leukemogenesis will be important in the development of targeted therapy. Approximately 10% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases have a mutation in IL-7Rα.
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