Results 101 to 110 of about 4,555,739 (141)

IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients

, 2004
Interleukin-2 (IL-2) and IL-7 are the most intriguing molecules in immune-based HIV infection treatment. An in vitro IL-2/IL-7 cross-talk due to IL-2-driven IL-7 receptor-alpha-chain (IL-7R alpha) down-modulation, potentially blocking IL-7 signalling has
M. Clerici, M. Moroni, G. Taskaris, L. Gazzola, F. Franzetti, L. Meroni, M. Galli, A. Gori, C. Molteni, G. Marchetti   +9 more
core   +2 more sources

IL-7–dependent and –independent lineages of IL-7R–dependent human T cells

Journal of Clinical Investigation
Infants with biallelic IL7R loss-of-function variants have severe combined immune deficiency (SCID) characterized by the absence of autologous T lymphocytes, but normal counts of circulating B and NK cells (T – B +
Arango-Franco CA, Ogishi M, Unger S, Delmonte OM, Orrego JC, Yatim A, Velasquez-Lopera MM, Zea-Vera AF, Bohlen J, Chbihi M, Fayand A, Sánchez JP, Rojas J, Seeleuthner Y, Le Voyer T, Philippot Q, Payne KJ, Gervais A, Erazo-Borrás LV, Correa-Londoño LA, Cederholm A, Gallón-Duque A, Goncalves P, Doisne JM, Horev L, Charmeteau-de Muylder B, Álvarez JÁ, Arboleda DM, Pérez-Zapata L, Vásquez-Echeverri E, Moncada-Vélez M, López JA, Caicedo Y, Palterer B, Patiño PJ, Montoya CJ, Chaldebas M, Zhang P, Nguyen T, Ma CS, Jeljeli M, Alzate JF, Cabarcas F, Khan T, Rinchai D, Prétet JL, Boisson B, Generalized Verrucosis Japanese Consortium, Marr N, Ibrahim R, Molho-Pessach V, Boisson-Dupuis S, Kiritsi D, Barata JT, Landegren N, Neven B, Abel L, Lisco A, Béziat V, Jouanguy E, Bustamante J, Di Santo JP, Tangye SG, Notarangelo LD, Cheynier R, Natsuga K, Arias AA, Franco JL, Warnatz K, Casanova JL, Puel A   +70 more
openaire   +6 more sources

The IL-7R alpha Pathway Is Quantitatively and Functionally Altered in CD8 T Cells in Multiple Sclerosis

, 2012
The IL-7R alpha single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS). IL-7Ra is a promising candidate to be involved in autoimmunity, because it regulates T cell homeostasis, proliferation, and ...
Wierenga - Wolf, Annet, Hintzen, Rogier, Verbraak, Evert, Kreft, Karim, Laman, Jon, van Meurs, Marjan, Oostra, Ben, Hintzen, Rogier Q., Kreft, Karim L., Oostra, Ben A., Laman, Jon D., Wierenga-Wolf, Annet F.   +11 more
core   +1 more source

MRI联合MMP-9、IL-7R对膝关节骨性关节炎发生发展的诊断价值研究

Zhongguo shiyan zhenduanxue
目的 分析磁共振成像(magnetic resonance imaging, MRI)联合基质金属蛋白酶-9((matrix metallo proteinase-9,MMP-9)、白介素7受体(Interleukin 7 receptor, IL-7R)对膝关节骨性关节炎发生发展的诊断价值。方法 选取2020年1月—2021年1月重庆市沙坝区人民医院收治的膝关节骨性关节炎患者60例为研究组，另选体检者40例为对照组。两组均行MRI检查及MMP-9、IL-7R水平检测。结果 研究组ADC值、MMP-9 ...
谢筱虎, 李虹成
doaj  

T lymphocytes regulate IEC homeostasis in an antigen-independent, IL-7R-dependent fashion.

, 2012
(A, B) Rag− (n = 6) and Rag−IL-7R− (n = 7) were reconstituted with 5×106 polyclonal CD4+ and CD8+ T cells from Thy1.1-congenic mice. Untreated Rag− (n = 8) and Rag−IL-7R− (n = 7) served as controls.
Thomas Schüler (181192), Christoph Loddenkemper (23477), Shabnam Shalapour (181157), Rainer Glauben (181165), Özen Sercan (181172), Stefan Bereswill (32410), Katrin Deiser (181160), André Fischer (32397), Stephane Chappaz (181174), Susanne M. Krug (181168), Markus M. Heimesaat (32396), Günter J. Hämmerling (181182), Daniela Finke (181180), Bernd Arnold (181188), Anja A. Kühl (181163), Michael Fromm (23852), Britta Siegmund (32398)   +16 more
core   +1 more source

Retroviral transfection of IL-7 R into IL-7R-/- bone marrow progenitors: Correction of lymphoid deficiency and induction of neutrophilia.

, 2005
Defects in the gene for the IL-7 receptor (R) chain are one cause of severe combined immunodeficiency disease (SCID) based on a strict requirement for IL-7 in T lymphoid development and survival.
DURUM S., LIWQ, KELLER JR, AIELLO, Francesca Bianca, JIANG Q, KLARMANN KD   +5 more
core  

MRI联合MMP-9、IL-7R对膝关节骨性关节炎发生发展的诊断价值研究 附视频

Zhongguo shiyan zhenduanxue
目的 分析磁共振成像(magnetic resonance imaging, MRI)联合基质金属蛋白酶-9((matrix metallo proteinase-9,MMP-9)、白介素7受体(Interleukin 7 receptor, IL-7R)对膝关节骨性关节炎发生发展的诊断价值。方法 选取2020年1月—2021年1月重庆市沙坝区人民医院收治的膝关节骨性关节炎患者60例为研究组，另选体检者40例为对照组。两组均行MRI检查及MMP-9、IL-7R水平检测。结果 研究组ADC值、MMP-9 ...
doaj   +2 more sources

Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer

Scientific Reports
Lung cancer is one of the most commonly diagnosed cancers worldwide and the leading cause of cancer-related deaths worldwide. In recent years, an increasing number of studies have shown that the tumor immune microenvironment (TIME) has a significant ...
Huan Cheng, Yajiao Shao, Ao Zhang, Caixia Li, Xinxin Li, Yuxin Fu, Jian Ming   +6 more
doaj   +1 more source

Identification of an expanded population of activated CD4(+) CD25(+) T cells expressing CD45RO and IL-7R in kidney transplant recipients

, 2007
Recent studies have shown that CD4+ CD25+ T cells belong to two functionally different T lymphocytes, i.e. regulatory T cells (Treg) or activated T cells (Tact), which can be distinguished based on the expression of CD45RO and IL-7R: Treg (FoxP3+) are ...
Codarri, Laura, Ciuffreda, Donatella, Pantaleo, Giuseppe, Pascual, Manuel, Venetz, Jean-Pierre, Vallotton, Laure   +5 more
core   +1 more source

IL-7 receptor (IL-7R; CD127) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source