Results 81 to 90 of about 4,555,739 (141)

Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure

Frontiers in Immunology, 2019
Recent studies demonstrate that the stable HIV-1 reservoir in resting CD4+ T cells is mostly formed from viruses circulating when combination antiretroviral therapy (ART) is initiated.
Nilu Goonetilleke, Nilu Goonetilleke, Genevieve Clutton, Genevieve Clutton, Ron Swanstrom, Ron Swanstrom, Sarah B. Joseph, Sarah B. Joseph, Sarah B. Joseph   +8 more
doaj   +1 more source

IL-7Rα signaling potentiates the anti-tumor activity of NK92 cells

Frontiers in Immunology
BackgroundNatural killer (NK) cells are promising candidates for cancer immunotherapy due to their safety and potent anti-tumor activity. However, their therapeutic efficacy is often limited by poor persistence and activity within the tumor ...
Chunli Wang, Chunli Wang, Seokmin Kim, Seokmin Kim, Ling-Zu Kong, Ling-Zu Kong, Inhwan Jang, Seona Jo, Seona Jo, Sunyoung Lee, Soo Yun Lee, Kee K. Kim, Tae-Don Kim, Tae-Don Kim, Tae-Don Kim   +14 more
doaj   +1 more source

IL-7R α polymorphisms in 60 Iranian multiple sclerosis patients.

Iranian journal of neurology, 2013
Multiple sclerosis (MS), a chronic inflammatory demyelinating disorder with neurodegenerative aspects, is more common among young adults, particularly women.This molecular study was designed to investigate the IL-7R α chain gene in Iranian MS patients.
Mojgan Ahmadzadeh, Raji, Alireza, Khosravi, Mohammad Hossein, Sanati, Seyed Massood, Nabavi, Reza, Hajihoseini, Ahmad, Ebrahimi, Mohammad Hossein, Sabour   +6 more
openaire   +2 more sources

Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population

Cancer Management and Research, 2019
Chan Zhang,1 Pincan Su,2 Wanlu Chen,1 Qi Li,1 Run Dai,1 YuJing Cheng,1 Jiangcun Yang31Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650032, People’s Republic of China; 2Laboratory of Blood ...
Zhang C, Su P, Chen W, Li Q, Dai R, Cheng YJ, Yang J   +6 more
doaj  

The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART

, 2011
We previously found an association between faster CD4+ T-cell recovery in HIV-infected patients receiving combination antiretroviral therapy (cART) and interleukin-7 receptor-alpha (IL-7R alpha) haplotype-2 in a predominantly Caucasian cohort. This study
Chua, K., Martin, J, Booth, DR, Deeks, S, C Muzoora, S R Lewin, G Stewart, Lewin, SR, T Spelman, Cameron, PU, I James, R Rajasuriar, Booth, D.R., S Deeks, Bangsberg, D.R., K Chua, Lewin, S.R., P U Cameron, Solomon, A, Martin, J., Stewart, G., Rajasuriar, R., Muzoora, C., J Martin, Deeks, S., Bangsberg, DR, Hunt, P, James, I, Gouillou, M., P Hunt, Spelman, T, D R Booth, Gouillou, M, Chua, K, Spelman, T., D R Bangsberg, Stewart, G, Muzoora, C, A Solomon, M Gouillou, Cameron, P.U., Hunt, P., Solomon, A., Rajasuriar, R, James, I.   +44 more
core   +1 more source

Dysregulated IL-7/IL-7R-CD132 Axis and Intestinal Microsporidiosis in Crohn’s Disease

Pathogens
Crohn’s disease (CD) is frequently accompanied by T-cell lymphopenia and impaired mucosal immunity, conditions that may predispose to intestinal microsporidiosis by Encephalitozoon cuniculi.
Carolina Hurtado-Marcos, Fernando Izquierdo, Soledad Fenoy, Carmen del Águila, Jaume Pérez-Griera, Salvador Benlloch, Cirilo Amorós, Carlos García Ballesteros, Francisca López Chuliá, Juan Carlos Andreu-Ballester, Carmen Cuéllar   +10 more
doaj   +1 more source

Correlation analyses between the number of IFN-γ producing cells among IFN-γ producers and the parameters associated with IL-7/IL-7R axis.

, 2018
Correlation analyses between the number of IFN-γ producing cells among IFN-γ producers and the parameters associated with IL-7/IL-7R axis.
María A. Natale (5744285), Gonzalo A. César (6053885), Susana A. Laucella (166597), Bruno Lococo (344862), Graciela Bertocchi (166575), María C. Albareda (166561), María G. Alvarez (166567), Melisa D. Castro Eiro (5744291)   +7 more
core   +1 more source

Effect of IL-7 and IL-7R blockade on cytokine production by peripheral blood t cells from patients with psoriatic arthritis

Медицинская иммунология
Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory joint disease, often associated with psoriasis. Interactions between immune cells, mainly T lymphocytes, and cells of the osteoarticular system are central in the pathogenesis of PsA ...
E. A. Blinova, O. A. Angelskaya, V. A. Kozlov   +2 more
doaj   +1 more source

Lung and serum IL-7 and B precursors IL-7R expression during allergic inflammation.

, 2016
IL-7 levels in the a) lung and b) serum are not affected by allergen exposure. c) Expression of IL-7R was decreased upon allergic exposure. d) No differences were found in the intensity of the expression of the IL-7R in total B cells (B220+SSClow) and ...
Apostolos Bossios (154223), Carina Malmhäll (154218), Maria Semitekolou (2938959), Jan Lötvall (84140), Konstantinos Samitas (2938953), Madeleine Rådinger (154228), Patricia Ramos-Ramirez (2938962), Tünde Deák (2938965), Mina Gaga (2938956), Margareta Sjöstrand (154233), You Lu (154239)   +10 more
core   +1 more source

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

Nature Communications, 2019
Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of ...
Hussein Al-Mossawi, Nicole Yager, Chelsea A. Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A. Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C. Knight, Paul Bowness, Benjamin P. Fairfax   +16 more
doaj   +1 more source