Results 71 to 80 of about 4,555,739 (141)

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

Nature Communications, 2017
IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell ...
Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang   +14 more
doaj   +1 more source

Lineage switch in childhood leukemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Lineage switch (LS) is a rare but aggressive immunophenotypic transformation of acute leukemia associated with limited therapeutic options and poor clinical outcome. Although LS has been increasingly recognized in the era of CD19‐directed immunotherapies, its biological basis remains incompletely understood.
Katharina Daugs, Anna Prazmo, Anindita Roy, Arndt Borkhardt   +3 more
wiley   +1 more source

A Pan‐Hepatic T‐Cell Atlas Identifies Disease‐Specific Immune Dysfunction and Therapeutic Targets for Immunotherapy

MedComm, Volume 7, Issue 11, November 2026.
A Pan‐HEpatic single‐cell Atlas of T cells (Pheat) was constructed covering chronic hepatitis, cirrhosis, hepatocellular carcinoma (HCC), and healthy controls. CD8+ exhausted T cells (Tex) and CD4+ regulatory T cells (Treg) were delineated profound through decoding molecular and cellular variance, immune checkpoint networks, pathway analysis, and drug ...
Si‐Yuan Chen, You‐Yuan Wang, Shuang‐Nan Zhou, Ming‐Ju Zhou, Xia Li, Wei‐Zhe Li, Meng‐Meng Zhu, Yu‐Xuan Yang, Ying Sun, Peiyao Fan, Jing Li, Xing Fan, Ruonan Xu, Yan‐Mei Jiao, Jin‐Wen Song, Cheng Zhen, Ming Shi, Chao Zhang, Fu‐Sheng Wang   +18 more
wiley   +1 more source

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7R gene expression in early human thymopoiesis and leukemia [PDF]

, 2009
Notch1 activation is essential for T-lineage specification of lymphomyeloid progenitors seeding the thymus. Progression along the T cell lineage further requires cooperative signaling provided by the interleukin 7 receptor (IL-7R), but the molecular ...
Enrique Martín-Gayo, María L. Toribio, García-Peydró, Marina, Toribio, María L., Esteban Ballestar, Ferrando, Adolfo, Ballestar Tarín, Esteban, Ballestar, Estéban, Manel Esteller, Esteller, Manel, Martín-Gayo, Enrique, Marina García-Peydró, Toribio, María Luisa, González-García, Sara, José Luis de la Pompa, Rafael Bornstein, Ferrando, Adolfo A., Bornstein, Rafael, Pompa, José Luis de la, Adolfo A. Ferrando, Sara González-García, Esteller, Manel, 1968-   +21 more
core   +1 more source

AAPM DWWSS report 449: Evaluation of imaging physics workforce, workload, and future needs in the United States

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Introduction In 2020, the American Association of Physicists in Medicine (AAPM) conducted a comprehensive imaging physics workforce survey (2020 Survey) to evaluate staffing needs, validate prior time and effort estimates, and explore workforce satisfaction.
Joseph R. Steiner, Shengwen Deng, Ching‐Mei Feng, Joshua M. Wilson, Mary Ellen Jafari, Megan E. Lipford, Lei Qin, Dustin Gress, David Jordan   +8 more
wiley   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, Volume 13, Issue 59, 23 October 2026.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

IL-7 in autoimmune diseases: mechanisms and therapeutic potential

Frontiers in Immunology
Interleukin-7 (IL-7) is a pleiotropic cytokine that plays a crucial role in the development, homeostasis, and function of the immune system. Growing evidence has demonstrated that IL-7 is involved in the pathogenesis of various autoimmune diseases ...
Ziyuan Zeng, Hanxiao Mao, Qirong Lei, Yuanmin He   +3 more
doaj   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, Volume 13, Issue 57, 14 October 2026.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Arthritis severity is inhibited in TSLPR deficient mice and upon blockade of the IL-7R.

, 2015
WT or TSLPR-/- mice were treated with PBS or anti IL-7Rα antibodies (anti IL-7R, 100 μg ip. on day 21, 24, 27, 30, and 33) and arthritis severity was graded by visual examination of the paws.
Sarita A. Y. Hartgring (760784), Cornelis E. Hack (760786), Cynthia R. Willis (760785), Joel A. G van Roon (760787), Maarten R. Hillen (760783), Timothy R. D. J. Radstake (168224), Floris P. J. G. Lafeber (552927)   +6 more
core   +1 more source