Results 51 to 60 of about 4,555,739 (141)

Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy.

, 2018
IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7R alpha, it is thought IL-15 is more important.
Rubinstein, Mark P., Charles D. Surh, Wrangle, John, Paulos, Chrystal M., Cole, David J., Surh, CD, Mehrotra, Shikhar, Johnson, C. Bryce, Li, Zihai   +8 more
core   +1 more source

Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition

iScience
Summary: IL-17-producing helper T (Th17) cells are long-lived and serve as central effector cells in chronic autoimmune diseases. The underlying mechanisms of Th17 persistence remain unclear. We demonstrated that abatacept, a CD28 antagonist, effectively
By Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma   +8 more
doaj   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Synergic effect of sex pheromone (7R,8S)-cis-7,8-epoxy-2-methyloctadec-17-ene on (+)-disparlure of the Asian gypsy moth, Lymantria dispar, in Korea

, 2018
field attraction test of (7R,8S)-cis-7,8-epoxy-2-methyloctadec-17-ene (=7R,8S-epo-2me-17ene-18Hy), a trace component of the sex pheromone gland of the Asian gypsy moth, (Lymantria dispar), traps that were baited with the trace component attracted more L.
Lee, Hyo-Rim, Il-Kwon Park, Park, Il-Kwon, Hyo-Rim Lee, Jung, Chan-Sik, Koh, Sang-Hyun, Chan-Sik Jung, Sang-Hyun Koh   +7 more
core   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science
Mounting evidence highlights the involvement of extra‐intestinal organs in inflammatory bowel disease (IBD) progression, yet the mechanisms underlying gut‐extraintestinal organ crosstalk remain poorly understood.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
doaj   +1 more source

Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system. [PDF]

PLoS ONE, 2009
BACKGROUND: High content immune profiling in peripheral blood may reflect immune aberrations associated with inflammation in multiple sclerosis (MS) and other autoimmune diseases affecting the central nervous system.
Nalini Kumar Vudattu, Sharon Kuhlmann-Berenzon, Mohsen Khademi, Vicki Seyfert, Thomas Olsson, Markus J Maeurer   +5 more
doaj   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy

Biomolecules
Cell–cell signaling through a network of cytokine receptors is pivotal for normal immune development and function, with disruptions of these signaling pathways being implicated in a variety of immune cell diseases.
Alister C. Ward
doaj   +1 more source

Noah's Raven, Noah's Son: The Metamorphoses of Blackness in Early Modern Readings of Genesis 8‐9

Renaissance Studies, EarlyView.
ABSTRACT Over the past half‐century, scholars have offered various theories to explain when and how an aetiology for black skin became part of the reception history of the so‐called Curse of Ham in Genesis 9—a text that does not include any reference to skin colour.
Ashleigh Elser
wiley   +1 more source

The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4(+)IL-7R(hi) T cells

, 2008
Mouse memory T cell precursors express IL-7 receptor-a (IL-7R), proliferate with homeostatic cytokines and undergo secondary expansions with antigen.
Rivino L, Sallusto F, Guarda G, Jarrossay D, Geginat J, Bertoni F, Lozza L, Rinadi A, Lanzavecchia A   +8 more
core   +1 more source