Results 91 to 100 of about 4,555,739 (141)

TSLP and IL-7R Variants Are Associated with Persistent Atopic Dermatitis

Journal of Investigative Dermatology, 2021
Ronald Berna, Nandita Mitra, Carolyn Lou, Joy Wan, Ole Hoffstad, Bradley Wubbenhorst, Katherine L. Nathanson, David J. Margolis   +7 more
openaire   +3 more sources

A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line

, 2009
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2009.In title on title page, [alpha] appears as lower case Greek letter.Includes bibliographical references.IL-7R[alpha] is one component of the heterodimeric IL-7R[alpha] receptor,
Trajman, Lily Christine
core  

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours [PDF]

, 2003
Interleukin-7 (IL-7) plays an important role in the normal development and maintenance of the human immune system. Its effects are mediated via its receptor, IL-7R. Ligand-receptor engagement results in a cascade of phosphorylation events mediated by
Al-Rawi, M. A. A., Mansel, R.E., Jiang, W.G., Mansel, R. E., Jiang, Wen Guo, Al-Rawi, M.A.A.   +5 more
core  

HIV regulation of the IL-7R: A viral mechanism for enhancing HIV-1 replication in human macrophages in vitro

, 2006
We report a novel mechanism, involving up-regulation of the interleukin (IL)-7 cytokine receptor, by which human immunodeficiency virus (HIV) enhances its own production in monocyte-derived macrophages (MDM) in vitro.
Frucht, D. M., Drenkow, J., Gingeras, T. R., Lankford, C. S. R., Dayton, A. I., Clouse, K. A., Rabin, R. L., Zhang, M., Schwartzkopff, F., Venkateshan, C.   +9 more
core   +1 more source

Mechanisms of Tongdu Tiaoshen acupuncture therapy in protecting against cerebral ischemia reperfusion injury☆

World Journal of Acupuncture - Moxibustion
Objective: To observe the potential mechanisms of Tongdu Tiaoshen (unblocking the governor vessel and regulating the mind) acupuncture therapy in protecting against cerebral ischemia-reperfusion injury (CIRI).Methods: SD rats were divided into a sham ...
Si-fang CHEN, Wei HAN, Chong CHEN, Xiao-li SUN, Wen ZHANG, Shan-bin SUN   +5 more
doaj   +1 more source

Reduced IL-7R T Cell Expression and Increased Plasma sCD127 in Late Presenting HIV-Infected Individuals

, 2017
BACKGROUND: Late presentation of HIV infection is associated with reduced chance of optimal immune recovery after initiating combination antiretroviral therapy (cART).
Thorsteinsson, Kristina, Jespersen, Sofie, Nielsen, Susanne D, Gaardbo, Julie C, Sambleben, Camilla, Hartling, Hans J, Ullum, Henrik, Gerstoft, Jan   +7 more
core   +1 more source

Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy

Nature Communications, 2016
Combination therapy with α-CTLA-4 and α-PD-1 is showing improved therapeutic effects in clinical trials. Here, the authors report that mechanistically in bladder cancer such effect depends upon an upregulation of T cell activity mediated by the IL-7/IL ...
Lewis Zhichang Shi, Tihui Fu, Baoxiang Guan, Jianfeng Chen, Jorge M. Blando, James P. Allison, Liangwen Xiong, Sumit K. Subudhi, Jianjun Gao, Padmanee Sharma   +9 more
doaj   +1 more source

Ovarian localization drives IL-7R-dependent CD8 coreceptor expression in peripheral double-negative T cells

Cellular and Molecular Life Sciences
The ovary is an immunologically dynamic tissue that coordinates recurrent inflammation-like remodeling while preserving local T cell tolerance, yet whether it actively instructs infiltrating lymphocyte phenotype or passively enriches pre-existing subsets
Toni Martin, Howard A. Young, Enitome E. Bafor   +2 more
doaj   +1 more source

Both the pre-BCR and the IL-7R alpha are essential for expansion at the pre-BII cell stage in vivo

, 2005
During B cell development, proliferative expansion takes place after expression of the pre-BCR. At this pre-BII cell stage, the IL-7R alpha is also expressed.
Erlandsson, L, Licence, S, Corcoran, AE, Gaspal, Fabrina, Lane, Peter, Martensson, IL   +5 more
core   +1 more source

Targeting Interleukin-7 Signalling in Ulcerative Colitis: Rationale and Emerging Clinical Evidence

Life
Ulcerative colitis (UC) remains difficult to control in a substantial proportion of patients despite an expanding range of advanced therapies. Interleukin-7 (IL-7) is a homeostatic cytokine that supports lymphocyte survival, persistence and intestinal ...
Magdalini Manti, Valentina Raspa, Kamal Patel, Sailish Honap   +3 more
doaj   +1 more source