Results 261 to 270 of about 9,618,357 (291)

IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors

The Journal of Immunology, 1995
Abstract IL-8 is a potent proinflammatory cytokine that has a key role in the recruitment and activation of neutrophils during inflammation. IL-8 reacts with neutrophils via two distinct types of IL-8-R. Receptor-specific Abs were raised against peptides derived from the first extracellular domain of each IL-8-R. Anti-IL-8-R1 and anti-
M E, Hammond, G R, Lapointe, P H, Feucht, S, Hilt, C A, Gallegos, C A, Gordon, M A, Giedlin, G, Mullenbach, P, Tekamp-Olson   +8 more
openaire   +2 more sources

IL-8 degradation byPorphyromonas gingivalisproteases

Microbial Pathogenesis, 1999
Gingival epithelial cells are the primary barrier to infection by periodontal pathogens. The production of chemotactic cytokines, including interleukin-8 (IL-8), is one mechanism the host uses in response to infection. In this study it was found that both gingival and oral epithelial cells produced IL-8, but after infection with the periodontal ...
J, Zhang, H, Dong, S, Kashket, M J, Duncan   +3 more
openaire   +2 more sources

Multiple sites on IL-8 responsible for binding to alpha and beta IL-8 receptors.

The Journal of Immunology, 1993
Abstract To define the structural features important for IL-8 binding to its two known receptors, mutants of IL-8 and melanoma growth-stimulating activity (MGSA) and chimerae consisting of segments of these two chemokines were constructed and purified from the pGEX 2T Escherichia coli expression vector. IL-8 alpha and beta receptors were
I U, Schraufstätter, D S, Barritt, M, Ma, Z G, Oades, C G, Cochrane   +4 more
openaire   +2 more sources

Differential expression of IL-8 and IL-8 receptors in benign, borderline and malignant ovarian epithelial tumours

Cytokine, 2013
Ovarian Cancer is the leading cause of death from gynecological malignancy. The poor prognosis is mainly due to presentation at a late stage and poor response to therapy. Much research is needed to identify diagnostic and prognostic biomarkers as well as therapeutic targets for ovarian cancer.
A, Browne, R, Sriraksa, T, Guney, N, Rama, S, Van Noorden, E, Curry, H, Gabra, E, Stronach, M, El-Bahrawy   +8 more
openaire   +2 more sources

CARCINOMA-CELLS EXPRESS IL-8 AND THE IL-8 RECEPTOR - THEIR INHIBITION ATTENUATES THE GROWTH OF CARCINOMA-CELLS

International Journal of Oncology, 1995
We investigated the expression of IL-8 and the IL-8 receptor (IL-8R) in human carcinoma cells and the role of IL-8 and IL-8R in the growth of carcinoma cells. IL-8 mRNA was detected in 16 of 20 (80%) carcinoma cell lines and 20 of 24 (83.3%) cancer tissues by Northern blot analysis.
T, Ishiko, K, Sakamoto, S, Yamashita, Y, Masuda, H, Kamohara, S, Mita, M, Hirashima, M, Ogawa   +7 more
openaire   +2 more sources

Roles of IL-8 in Ocular Inflammations: A Review

Ocular Immunology and Inflammation, 2011
This review presents the current in vitro and in vivo animal and human research on the roles of IL-8 in ocular inflammatory diseases.Data sources were a literature review using Pub Med, Medline, and ISI databases (from 1990 to 2011). Search items included interleukine-8 (IL-8), CXCL8, chemokines, cytokines, alone or in combination with the, serum ...
Hassan, Ghasemi, Tooba, Ghazanfari, Roya, Yaraee, Soghrat, Faghihzadeh, Zuhair Mohammad, Hassan   +4 more
openaire   +2 more sources

IL-8 mRNA expression and IL-8 production by acute myeloid leukemia cells.

Leukemia, 1993
Purified leukemic cells from 30 acute myeloid leukemia (AML) cases at diagnosis were investigated for the presence of interleukin 8 (IL-8) mRNA by Northern blot analysis. IL-8 specific transcripts were detected in uncultured blasts in 14/30 cases, 10/14 from patients with M4-M5 and 4/14 from cases with M0-M3 morphology.
VINANTE, Fabrizio, RIGO, Antonella, Vincenzi Carlo, RICETTI, Maria Maddalena, Marrocchella Raffaella, CHILOSI, Marco, CASSATELLA, Marco Antonio, Bonazzi Luisa, PIZZOLO, Giovanni   +8 more
openaire   +2 more sources

Expression and one-step ion-exchange purification of (AAR)IL-8 (human IL-8 receptor antagonist)

Protein Expression and Purification, 2005
Interleukin-8 (IL-8) is C-X-C chemokine, which is produced by a variety of cells. IL-8 plays an important role in the inflammatory response and may be a therapeutic target for some inflammatory diseases. To develop an IL-8 receptor antagonist, (AAR)IL-8 (IL-8 receptor antagonist) was constructed and successfully expressed in Escherichia coli. (AAR)IL-8
Dengyong, Hou, Zhen, Yan, Jihong, Shi, Wei, Han, Yingqi, Zhang   +4 more
openaire   +2 more sources

NAP-1/IL-8 in Rheumatoid Arthritis

1991
Neutrophil activating peptide 1, or interleukin-8 (NAP-1, IL-8), was isolated almost simultaneously by several groups as a neutrophil chemotactic or activating peptide from supernatants of endotoxin stimulated monocytes (1–5). The major form with 72 amino acids, and an approximate molecular weight of 8.4 kD, has since been shown to have activities on a
I J, Lindley, M, Ceska, P, Peichl
openaire   +2 more sources

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2014
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openaire   +1 more source