Results 101 to 110 of about 16,465 (200)

Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients.

, 2009
International audienceIL-23 is the main inductor in Th17 polarization of naive T cells, inducing IL-17 production. IL-17 has been demonstrated to be elevated in ankylosing spondylitis (AS). The p40 subunit is common to IL-12 and IL-23.
Racadot, Evelyne, Wendling, Daniel, Cedoz, Jean-Pierre   +2 more
core   +1 more source

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors

, 2019
Purpose: The NHS-IL12 immunocytokine is composed of two IL12 heterodimers fused to the NHS76 antibody. Preclinical studies have shown that this antibody targets IL12 to regions of tumor necrosis by binding histones on free DNA fragments in these areas ...
Montgomery, Agnes S., McMahon, Sheri, Jochems, Caroline, Silver, Matthew R., Gulley, James L., Bertotti, Elisa, Lamping, Elizabeth, Strauss, Julius, Marte, Jennifer L., Donahue, Renee N., Madan, Ravi A., Schlom, Jeffrey, Heery, Christopher R., Bilusic, Marijo, Kim, Joseph W.   +14 more
core   +1 more source

Evaluation of the Risk of Psoriatic Arthritis in Patients With Psoriasis Undergoing Biological Treatment. Global Population Study (TRINETX)

Actas Dermo-Sifiliográficas
Introduction: Psoriatic arthritis (PsA) is an inflammatory condition associated with psoriasis (PsO), with variable prevalence ranging from 6% to 42%. Despite the known link between PsO and PsA, reliable biomarkers for predicting PsA onset remain elusive.
R. Rivera-Diaz, B. Joven, G. Hernandez-Ibarburu, C. García-Donoso, J.L. Pablos, P.L. Ortiz-Romero   +5 more
doaj   +1 more source

Dendritic cells engineered to express CD40L continuously produce IL12 and resist negative signals from Tr1/Th3 dominated tumors

, 2006
TNFalpha-matured dendritic cells (DCs) pulsed with tumor antigens are being evaluated as cancer vaccines. It has been shown that DCs produce IL12 during a limited time span and subsequently enter a stage of IL12 exhaustion.
Tötterman, Thomas H.,, Angelica Loskog, Ninalga, Christina,, Loskog, Angelica,, Christina Ninalga, Thomas H. Tötterman   +5 more
core   +1 more source

Combination of HDAC inhibition and cytokine enhances therapeutic HPV vaccine therapy

Journal for ImmunoTherapy of Cancer
Background Human papillomavirus (HPV)-associated malignancies continue to present a major health concern despite the development of prophylactic vaccines. Standard therapies offer limited benefit to patients with advanced-stage disease.
Jeffrey Schlom, James L Gulley, Caroline Jochems, Sofia R Gameiro, Wiem Lassoued, Daniel Burnett, Lisa K Poppe, Nicholas Roller, Miriam Marlene Medina-Enríquez, Katherine E Lothstein, Asma S Khelifa, Masaya Miyamoto   +11 more
doaj   +1 more source

Immunocytokine NHS-IL12 [PDF]

, 2020
openaire   +1 more source

Th1 and Th2 Immune response in Hymenolepis nana infection

مجله دانشگاه علوم پزشکی گرگان, 2008
Background & Objective: Although many experimental studies provide convincing evidence, that type II immunity is protective against helminthes, recent data in mice reveal that Th1 are also important in some cestods like Hymenolepis nana.
Abolghasem Ajami, Araz Mohammad Merabei, Farsheideh Abedian, Roya Ghavami   +3 more
doaj  

Safety and Efficacy of Intratumoral MEDI1191, an IL12 mRNA Lipid Nanoparticle, plus Intravenous Durvalumab in Patients with Advanced Solid Tumors: A First-in-Human Study. [PDF]

Clin Cancer Res
Carneiro BA, Marron T, Zamarin D, Castañón E, Patel SP, Subbiah V, Mehmi I, El-Khoueiry A, Oberoi A, Abadier M, Jennings EC, Dubois V, Chen Z, Chen X, Elgeioushi N, Durham NM, Ridgway B, Fraenkel PG, Azaro A, Hamid O.   +19 more
europepmc   +1 more source

Neutralizing the IL12/IL23 p40 Subunit Prevents Immune Checkpoint Blockade Toxicity without Compromising Antitumor Efficacy. [PDF]

Cancer Immunol Res
Groeneveldt C, Vadgama D, Onrust-van Schoonhoven A, Whyte D, Hofman MM, Rozendaal NEM, van Nimwegen M, Eterman M, Dumoulin DW, Mathijssen RHJ, Joosse A, van der Veldt AAM, Boon L, Doukas M, Samsom JN, Stadhouders R, Dammeijer F, Aerts JGJV, Joosse ME.   +18 more
europepmc   +1 more source

Single-Dose TACE-Like Injection of Sustained-Release Panobinostat/IL-12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models. [PDF]

Adv Sci (Weinh)
Yu H, Li L, Surwase SS, Zhou XMM, Qian H, Sunshine JC, Selaru FM, Green JJ.   +7 more
europepmc   +1 more source