Results 81 to 90 of about 16,465 (200)

Quantitative evaluation to efficacy and safety of therapies for psoriasis: A network meta-analysis

Molecular Pain, 2018
Therapies treating psoriasis can be categorized into five classes according to their mechanism: anti-metabolites (AM), anti-interleukin-12/23 agents (anti-IL12/23), anti-interleukin-17 agents (anti-IL17), anti-T-cell agent (ANT), and anti-tumor necrosis ...
Jingjing Lv, Dongmei Zhou, Yan Wang, Jingxia Zhao, Zhaoxia Chen, Jinchao Zhang, Tingting Di, Jing Hu, Bo Li, Ping Li, Feng Huang   +10 more
doaj   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, Volume 74, Issue 4, Page 1156-1173, October 2026.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Binding of IL12-SS1 (Fv) to MSLN and cancer cells.

, 2013
(A) The binding specificity of IL12-SS1 (Fv) on MSLN was detected by ELISA. (B) FACS analysis of IL12-SS1 (Fv) on mesothelin-expressing cancer cells. NCI-H226, OVCAR-3, H9, A431, and HEK-293 cells were stained with IL12-SS1 (Fv) which was detected by PE ...
Wei Gao (2085), Heungnam Kim (156424), Mitchell Ho (156431)   +2 more
core   +1 more source

p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome

Nature Communications
Radiation-induced gastrointestinal syndrome is a major complication and limiting factor for radiotherapy. Tumor suppressor p53 has a protective role in radiation-induced gastrointestinal toxicity. However, its underlying mechanism remains unclear.
Jianming Wang, Chun-Yuan Chang, Xue Yang, Fan Zhou, Juan Liu, Jill Bargonetti, Lanjing Zhang, Ping Xie, Zhaohui Feng, Wenwei Hu   +9 more
doaj   +1 more source

The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model

Journal of Biomedical Science, 2012
Background Microglial cells are the predominant immune cells in malignant brain tumors, but tumors may release some factors to reduce their defensive functions.
Chiu Tsung-Lang, Wang Mei-Jan, Su Chin-Cheng   +2 more
doaj   +1 more source

Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12 [PDF]

, 2017
Proinflammatory cytokines have been used for several years in patients with advanced cancer but their administration is typically associated with severe toxicity hampering their application to therapeutically active regimens. This problem can be overcome
Sommavilla, Roberto, Pasche, Nadine, Roesli, Christoph, Kaspar, Manuela, Villa, Alessandra, Giovannoni, Leonardo, Trachsel, Eveline, Neri, Dario   +7 more
core  

Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD

Gastroenterology Research and Practice, 2018
Despite the acknowledged contribution of eosinophils to the disease pathogenesis, available data on cytokines closely related to the peripheral eosinophils in inflammatory bowel disease (IBD) are scattered.
Katarzyna Neubauer, Malgorzata Matusiewicz, Iwona Bednarz-Misa, Sabina Gorska, Andrzej Gamian, Malgorzata Krzystek-Korpacka   +5 more
doaj   +1 more source

IL12 integrated into the CAR exodomain converts CD8(+) T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors

, 2021
Chimeric antigen receptor (CAR)-redirected T cell therapy often fails to control tumors in the long term due to selecting cancer cells that downregulated or lost CAR targeted antigen.
Hannappel, Lisa, Chmielewski, Markus, Abken, Hinrich, Barden, Markus, Sachinidis, Agapios, Hombach, Andreas, Rappl, Gunter, Hinrich Abken, Markus Barden, Lisa Hannappel, Markus Chmielewski, Andreas Hombach, Agapios Sachinidis, Gunter Rappl   +13 more
core   +1 more source

Interference of retroviral envelope with vaccine-induced CD8+ T cell responses is relieved by co-administration of cytokine-encoding vectors

Retrovirology, 2017
Background Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but also in gene-based immunizations using retroviral immunogens, where envelope interferes with the
Nadine Bongard, Dennis Lapuente, Sonja Windmann, Ulf Dittmer, Matthias Tenbusch, Wibke Bayer   +5 more
doaj   +1 more source

Impact of initiation of targeted therapy on the use of psoriatic arthritis-related treatments and healthcare consumption: a cohort study of 9793 patients from the French health insurance database (SNDS)

RMD Open
Objectives To assess the potential impact of targeted therapies for psoriatic arthritis (PsA) on symptomatic treatments (non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, opioid analgesics), methotrexate and mood disorder treatments and on
Pascal Claudepierre, Laura Pina Vegas, Emilie Sbidian, Siham Iggui   +3 more
doaj   +1 more source