Results 61 to 70 of about 16,465 (200)

Safety and Feasibility of Infusing Ex Vivo Expanded Allogeneic Canine Natural Killer Cells for the Treatment of Metastatic Solid Tumours

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Companion canines need advances in therapeutic options for solid tumour malignancies. Natural killer (NK) cell infusions offer a promising treatment modality in canines with solid tumours. Autologous natural killer products are limited by dysfunctional immunity and a manufacturing process that delays care whereas allogeneic NK cells offer the ...
Allison M. Weisnicht, Fernanda Szewc, Monica Moonkyung Cho, Han‐Yun Hannah Cheng, Swetha Ganesh, Lauren Mahoney, Kathryn Fox, Portia R. Smith, Mallery Olsen, Rebecca M. Richards, David M. Vail, Christian M. Capitini   +11 more
wiley   +1 more source

Altered Adaptive Cellular Immune Function in a Group of Egyptian Children with Autism [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: There is a growing evidence of immune system alteration in children with Autism Spectrum Disorder (ASD). These changes may include higher levels of pro-inflammatory cytokines in plasma, Cerebrospinal Fluid (CSF) and brain cells.
Engy A. Ashaat, Khaled H. Taman, Naglaa Kholoussi, Mona O. El Ruby, Moushira Erfan Zaki, Maged A. El Wakeel, Neveen A. Ashaat, Samira Ismail Ibrahim   +7 more
doaj   +1 more source

Systemic Inflammation in Dogs With Atopic Dermatitis Compared to Healthy Dogs and Dogs With Pemphigus Foliaceus: A Study Using a Limited Cytokine Panel

Veterinary Dermatology, EarlyView.
Background: Atopic dermatitis (AD) is a common chronic, pruritic and inflammatory skin disease in both humans and dogs. In people, AD is increasingly recognised as a systemic inflammatory disease in which immune dysregulation drives chronic inflammation extending beyond the skin, particularly in moderate‐to‐severe disease. Whether a comparable systemic
Ina Herrmann, Lisa B. Mamo, Petra Bizikova   +2 more
wiley   +1 more source

AaGroEL induces IL12 expression.

, 2016
Human PBMCs were cultured with 20μg/ml rAaGroEL protein at 16h and 24h.The RPMI medium and PMA (25 ng/ml) in the presence of Ionomycin (1 mg/ml) were used as negative (NC) and positive controls (PC), respectively.
Ayten Nalbant (299270), Tahsin Saygılı (299267)   +1 more
core   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Data_Sheet_1_Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells.pdf

, 2019
IL12 is an immune-stimulatory cytokine for key immune cells including T cells and NK cells. However, systemic administration of IL12 has serious side effects that limit its clinical application in patients.
Zonghai Li (500556), Xiuqi Wu, Xiuqi Wu (4092514), Yi Wang (32470), Hua Jiang (123031), Hua Jiang, Bizhi Shi (500555), Bizhi Shi, Yi Wang, Yansha Sun, Yiwei Dong, Yiwei Dong (2832761), Yansha Sun (7004492), Jingwen Su, Zonghai Li, Hong Luo (205745), Jingwen Su (8152617), Ruixin Sun, Ruixin Sun (475611), Hong Luo   +19 more
core   +1 more source

Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2

JCI Insight, 2023
Engineered cytokine–based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies.
Brendan L. Horton, Alicia D. D’Souza, Maria Zagorulya, Chloe V. McCreery, Gita C. Abhiraman, Lora Picton, Allison Sheen, Yash Agarwal, Noor Momin, K. Dane Wittrup, Forest M. White, K. Christopher Garcia, Stefani Spranger   +12 more
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Development of an IL12 Prodrug to Treat Solid Tumors with Minimal Toxicity [PDF]

Cytokines are secreted molecules that guide the immune system to respond correctly to various challenges. Among all cytokines, IL12 is perhaps the most powerful at polarizing the immune response into a Type 1, cell-mediated phenotype.
Moon, Benjamin Ik
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source