Results 51 to 60 of about 16,465 (200)

Supplementary Fig. S.5 from NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine

, 2017
In vitro comparison of IL-12 expression levels from G-less MRB-IL12-ICV and MG1-IL12-ICV.
Abhirami A. Ananth (2794732), Andrew P. Makrigiannis (14911220), E. Celia Marginean (15115049), Jiqing Zhang (419946), Michael A. Kennedy (230327), Shalini Sahi (14991576), Greg O. Cron (9936684), Blair Macdonald (15115046), Charles Lefebvre (15114515), Almohanad A. Alkayyal (2794729), Christiano Tanese de Souza (2794726), Ahmad Bakur Mahmoud (13946295), David F. Stojdl (14049867), Rebecca C. Auer (2794744), John C. Bell (206340), Lee-Hwa Tai (2794741)   +15 more
core   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

Malaria Journal, 2010
Background Malarial anaemia is characterized by destruction of malaria infected red blood cells and suppression of erythropoiesis. Interleukin 12 (IL12) significantly boosts erythropoietic responses in murine models of malarial anaemia and decreased IL12
Slutsker Laurence, Lal Altaf A, Terlouw Dianne, Nahlen Bernard, Kariuki Simon, ter Kuile Feiko, Crawford Sara, Eng Jodi, Prather Donald, Zhang Lyna, Udhayakumar Venkatachalam, Shi Ya   +11 more
doaj   +1 more source

Systemic Treatment and Outcome in Erythrodermic Psoriasis: A Retrospective Multicenter Study

International Journal of Dermatology, EarlyView.
This multicentre real‐world study illustrates the heterogeneity of systemic treatment approaches in erythrodermic psoriasis (EP) in Bavaria, Germany. Adverse events were more frequently observed with conventional therapies, whereas biologic therapies showed favorable outcomes.
Julian Kögel, Sandra Schuh, Julia Welzel, Michael Sticherling, Lukas Sollfrank, Carola Berking, Teodora Pumnea, Valerie Glatzel, Lars French, Felix Lauffer, Martin Valentin Vitus, Tilo Biedermann, Susanne Bauer, Michael Spindler, Mark Berneburg, Dennis Niebel   +15 more
wiley   +1 more source

Construction of IL12-SS1 (Fv) fusion protein.

, 2013
(A) The map of the baculovirus expression vector. IL12-SS1 (Fv) was inserted at the recombination sites attB1 and attB2 using the gateway cloning system. (B) Cloning strategy and schematic representation of the IL12-SS1 (Fv) fusion protein. The IL12-SS1 (
Wei Gao (2085), Heungnam Kim (156424), Mitchell Ho (156431)   +2 more
core   +1 more source

Risk of cancer in psoriasis patients treated with biologic therapy: A BADBIR cohort study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
No evidence of an increased risk of incident cancer or KC was observed with biologic versus non‐biologic systemic therapies or across the biologic classes evaluated. Abstract Background There are concerns that biologic therapies for psoriasis may increase cancer risk. Objectives To compare risks of (i) incident cancer excluding keratinocyte carcinomas (
Oras A. Alabas, Kayleigh J. Mason, Mark Lunt, Sarah Ryan, Nick J. Reynolds, Catherine H. Smith, Christopher B. Bunker, Christopher E. M. Griffiths, Adele C. Green, Richard B. Warren   +9 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study. [PDF]

PLoS Computational Biology, 2014
Innate and type 1 cell-mediated cytotoxic immunity function as important extracellular control mechanisms that maintain cellular homeostasis. Interleukin-12 (IL12) is an important cytokine that links innate immunity with type 1 cell-mediated cytotoxic ...
David J Klinke
doaj   +1 more source

Factors influencing the effectiveness of surgical therapy of peri‐implantitis

Periodontology 2000, EarlyView.
Abstract Background Surgical therapy is required in the majority of peri‐implantitis cases due to the inconsistent efficacy of non‐surgical approaches. Although surgical treatment generally offers higher predictability, reported success rates vary widely.
Ausra Ramanauskaite, Wenije Zhou, Emilio A. Cafferata, Frank Schwarz   +3 more
wiley   +1 more source

IL-12Rβ1 deficiency corresponding to concurrency of two diseases, mendelian susceptibility to mycobacterial disease and Crohn's disease

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2019
Background: The interleukin-12 receptor β1 (IL-12Rβ1) deficiency is a primary immunodeficiency (PID), affecting the immunological pathway of interleukin 12/interferon- γ (IL12/IFN-γ) axis and interleukin 23 receptor (IL23R).
Razieh Khoshnevisan, Nioosha Nekooei-marnany, Christoph Klein, Daniel Kotlarz, Mahdieh Behnam, Vajihe Ostadi, Majid Yaran, Abbas Rezaei, Roya Sherkat   +8 more
doaj   +1 more source