Results 31 to 40 of about 16,465 (200)

Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Leishmania major infection induces robust interleukin-12 (IL12) production in human dendritic cells (hDC), ultimately resulting in Th1-mediated immunity and clinical resolution.
Michelle A Favila, Nicholas S Geraci, Asha Jayakumar, Suzanne Hickerson, Janet Mostrom, Salvatore J Turco, Stephen M Beverley, Mary Ann McDowell   +7 more
doaj   +1 more source

Development of an IL12 Prodrug to Treat Solid Tumors with Minimal Toxicity

, 2022
Cytokines are secreted molecules that guide the immune system to respond correctly to various challenges. Among all cytokines, IL12 is perhaps the most powerful at polarizing the immune response into a Type 1, cell-mediated phenotype.
Moon, Benjamin Ik
core   +1 more source

Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

OncoImmunology, 2017
NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest and
Franziska Eckert, Ivan Jelas, Moritz Oehme, Stephan M. Huber, Katja Sonntag, Christian Welker, Stephen D. Gillies, Wolfgang Strittmatter, Daniel Zips, Rupert Handgretinger, Karin Schilbach   +10 more
doaj   +1 more source

IL12/IL23 Inhibition in the Treatment of Psoriatic Arthritis [PDF]

Current Treatment Options in Rheumatology, 2015
Psoriatic arthritis (PsA) is a potentially crippling systemic inflammatory joint disease with a heterogeneous clinical presentation that may include articular inflammation, enthesitis, dactylitis, abnormal bone turnover, and plaque psoriasis. Until very recently, patients with PsA had very few treatment options available to them and suffered immense ...
Mahta Mortezavi, Christopher Ritchlin
openaire   +1 more source

Changes in Liver Cell Apoptosis after Vaccination by Schistosomulae Antigen and/or Artesunat Treatment in Murine Schistosoma Mansoni [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases, 2018
Background and study aim: The target for a schistosoma vaccine or treatment is the reduction in morbidity. The hope for vaccine or treatment is to decrease worm burden  and egg pathology to the least percentage, this work aimed to compare between ...
Shereen Ibrahim, Magda Elsettawy
doaj   +1 more source

Immune Markers and Risk of Pancreatic Cancer in the European EPIC Cohort. [PDF]

Int J Cancer
The immune system has been implicated as a major driver in pancreatic cancer etiology. Previous cohort studies have found associations between pancreatic cancer and single immune system‐derived markers, but omics‐based evidence remains scarce. In this prospective case–control study, the authors investigated 92 proteins involved in immune reactions and ...
Katzke VA, Chen Y, Dutta S, Canzian F, Andersen JLM, Rostgaard-Hansen AL, Bouteille L, Rebours V, Truong T, Schulze MB, Bendinelli B, Pala V, Simeon V, Tumino R, Sacerdote C, Vermeulen R, Kolijn PM, Elias SG, Crous-Bou M, Sánchez MJ, Jimenez-Zabala A, Huerta JM, Guevara M, Wareham N, Breeur M, Johansson M, Yarmolinsky J, Campa D, Kaaks R.   +28 more
europepmc   +2 more sources

20201229pdtedSupplementaryFigures.pdf from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

, 2021
20201229pdtedSupplementaryFigures.pdf from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant ...
Leonid Gaidukov (15086518), Andrew Grube (15086512), Douglas E. Williams (15086527), Nuruddeen D. Lewis (15086491), Scott Estes (15086521), Christine McCoy (10284625), Chang Ling Sia (15086494), Michael Doherty (94933), Ke Xu (134879), Jorge Sanchez-Salazar (15086515), Adam Boutin (15086509), Kevin Dooley (201814), Sonya Haupt (15086500), Kyriakos D. Economides (15086524), Katherine Kirwin (15086497), Sriram Sathyanarayanan (3426824), Su Chul Jang (15086506), Gauri Mahimkar (15086503), Tong Zi (622015), Bryan Choi (7867907)   +19 more
core   +1 more source

Phase I trial of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for the treatment of metastatic pancreatic cancer

Molecular Therapy: Oncolytics, 2021
The safety of oncolytic adenovirus-mediated suicide and interleukin-12 (IL12) gene therapy was evaluated in metastatic pancreatic cancer patients. In this phase I study, a replication-competent adenovirus (Ad5-yCD/mutTKSR39rep-hIL-12) expressing yCD ...
Kenneth N. Barton, Farzan Siddiqui, Robert Pompa, Svend O. Freytag, Gazala Khan, Irina Dobrosotskaya, Munther Ajlouni, Yingshu Zhang, Jingfang Cheng, Benjamin Movsas, David Kwon   +10 more
doaj   +1 more source

Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold

Journal of Nanobiotechnology, 2021
Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature.
Angelo Corti, Angelina Sacchi, Anna Maria Gasparri, Matteo Monieri, Giulia Anderluzzi, Barbara Colombo, Alessandro Gori, Anna Mondino, Flavio Curnis   +8 more
doaj   +1 more source

Figure 4. Biodistribution of HRS3-scFv-IL12 and HRS3-scFv-Fc-IL12 fusion proteins.

, 2013
HRS3-scFv-IL12 and HRS3-scFv-Fc-IL12 fusion proteins were purified and labeled with 131I as described in Materials and Methods. SCID mice were s.c. transplanted with CD30+ L540cy Hodgkin's lymphoma cells (2×107/animal) and animals with established tumors
Stefan Guhlke (307234), Andreas A. Hombach (169001), Claudia Heuser (307231), Björn Friedrichs (307229), Hinrich Abken (107201), Tobias Jahn (307225), Martin Zuther (307227)   +6 more
core   +1 more source