Results 11 to 20 of about 16,465 (200)
Novel immunocytokine IL12-SS1 (Fv) inhibits mesothelioma tumor growth in nude mice. [PDF]
PLoS ONE, 2013 Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of malignant mesothelioma. Monoclonal antibodies against mesothelin are being evaluated for the treatment of mesothelioma.
Heungnam Kim, Wei Gao, Mitchell Ho
doaj +2 more sources
Scientific Reports, 2019 The Newcastle disease virus (NDV) strain AF2240 is an avian avulavirus that has been demonstrated to possess oncolytic activity against cancer cells.
Zahiah Mohamed Amin +10 more
doaj +2 more sources
Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma. [PDF]
PLoS ONE, 2015 Interleukin (IL)-12 is a pro-inflammatory cytokine that mediates T-helper type 1 responses and cytotoxic T-cell activation, contributing to its utility as anti-cancer agent.
Melissa Paoloni +16 more
doaj +3 more sources
An IL12-IL2-antibody fusion protein targeting Hodgkin's lymphoma cells potentiates activation of NK and T cells for an anti-tumor attack. [PDF]
PLoS ONE, 2012 Successful immunotherapy of Hodgkin's disease is so far hampered by the striking unresponsiveness of lymphoma infiltrating immune cells. To mobilize both adoptive and innate immune cells for an anti-tumor attack we fused the pro-inflammatory cytokines ...
Tobias Jahn +6 more
doaj +2 more sources
Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells
OncoImmunology, 2018 Interleukin-12 (IL12) (p35/p40 complex) is a heterodimeric cytokine with potent anti-tumor activity. However, its short serum half-life and high dose-related toxicities limit its clinical efficacy.
Keunok Jung +6 more
doaj +2 more sources
The Role Activity of Complement, TNFα & IL12 in Pathogenesis Dengue Virus
Indonesian Journal of Tropical and Infectious Disease, 2010 Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial.
Soegeng Soegijanto +3 more
doaj +2 more sources
Restoration of natural killer cell antimetastatic activity by IL12 and checkpoint blockade
Cancer Research, 2017 Immune checkpoint therapies target tumor antigen-specific T cells, but less is known about their effects on natural killer (NK) cells, which help control metastasis.
Paulina Kulig +17 more
core +5 more sources
, 2022 Supplementary Data from Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic ...
Christina Pfirschke (15031772) +21 more
core +7 more sources
FXTAS presents with upregulation of the cytokines IL12 and TNFα [PDF]
Parkinsonism & Related Disorders, 2021 Fragile X Tremor and Ataxia Syndrome is a progressive neurodegenerative disorder that develops in some FMR1 premutation carriers. The objective of this study is to characterize how cytokine levels are altered in the FXTAS brain.Fresh frozen cerebellar tissue from FXTAS cases and controls was homogenized and analyzed for 12 different cytokines using a ...
Dufour, Brett D +2 more
openaire +4 more sources
Adaptive Immunity in Marsupials. [PDF]
J Exp Zool A Ecol Integr PhysiolComparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Jol CL, Stannard HJ, Old JM.
europepmc +2 more sources