Results 71 to 80 of about 16,465 (200)

Assessment of DNA vaccine encoding Toxoplasma gondii microneme complete gene and IL-12 as adjuvant in BALB/c mice [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Toxoplasma gondii is an obligate intracellular protozoan parasite that causes toxoplasmosis in humans and animals. Micronemes (MICs) are effective candidates for DNA vaccine.
Fatemeh Ghafarifar, Mohammad Jafarimodrek, Hossein Vazini, Zohreh Sharifi, Abdolhossein Dalimi, Mohammad Saaid Dayer   +5 more
doaj   +1 more source

Oncolytic Virus Encoding a Master Pro-Inflammatory Cytokine Interleukin 12 in Cancer Immunotherapy

Cells, 2020
Oncolytic viruses (OVs) are genetically modified or naturally occurring viruses, which preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti-tumor immunity.
Hong-My Nguyen, Kirsten Guz-Montgomery, Dipongkor Saha   +2 more
doaj   +1 more source

The FOXQ1/SSBP2 Regulatory Axis Drives Malignant Progression of Melanoma

Molecular Carcinogenesis, Volume 65, Issue 11, Page 1459-1477, November 2026.
ABSTRACT Melanoma is a highly aggressive skin cancer with poor prognosis, often linked to excessive UV exposure. Despite advancements in immunotherapy and targeted treatments, melanoma's invasiveness and metastatic potential remain significant challenges.
Xiaoyu Zhang, Yu Hou, Jiahui Liu, Yuehua Han, Jiangang Feng   +4 more
wiley   +1 more source

Supplementary Data from Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity

, 2022
Supplementary Data from Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor ...
Jun Zhang (48506), Mia Han (15098522), Reneta Hermiz (15026670), William L. Redmond (15017781), David A. Canton (15098537), Ravindra Gujar (9922832), Erica Browning (183552), Anandaroop Mukhopadhyay (195990), Adil I. Daud (15019347), Christopher G. Twitty (14985561), Jack Y. Lee (15098528), Annah S. Rolig (15098534), Jon Salazar (15098531), Alain P. Algazi (15036980), Bianca Nguyen (15098525), Lauren Svenson (15039650)   +15 more
core   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, Volume 104, Issue 10, Page 996-1014, November‐December 2026.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Preclinical and clinical studies of a tumor targeting IL-12 immunocytokine

Frontiers in Oncology
The clinical success of immune checkpoint inhibitors (ICIs) has demonstrated the promise and challenges of cancer immunotherapy. There is an unmet need to develop novel cancer therapies that can provide clinical benefit for most patients with solid ...
Christine M. Minnar, Grace Lui, James L. Gulley, Jeffrey Schlom, Sofia R. Gameiro   +4 more
doaj   +1 more source

Macrophage lipid efflux regulates the tumour microenvironment in early‐stage lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Macrophages undergo metabolic rewiring even during early tumourigenesis. 2. Main alterations of macrophages are conserved between human and mice in early‐stage lung adenocarcinoma. 3. Tumour‐associated macrophages are characterised by enhanced lipid efflux 4.
Yujie Zheng, Yuan Wang, Yalin Wang, Yue Shi, Hui Kong, Shaohua Lu, Yong Zhang, Jie Hu, Jian Zhou, Xiangdong Wang, Meng Xiang, Qiong Liu, Hongyi Xin, Charles A. Powell, Fred R. Hirsch, Chunxue Bai, Yuanlin Song, Jun Yin, Dawei Yang   +18 more
wiley   +1 more source

Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12

, 2010
Proinflammatory cytokines have been used for several years in patients with advanced cancer but their adminis-tration is typically associated with severe toxicity hamper-ing their application to therapeutically active regimens.
Sommavilla, Roberto, Pasche, Nadine, Dario Neri, Giovannoni, Leonardo, Nadine Pasche, Trachsel, Eveline, Neri, Dario; id_orcid, Roesli, Christoph, Kaspar, Manuela, Villa, Alessandra, Manuela Kaspar, Ra Villa, Alessandra Villa, Eveline Trachsel, Leonardo Giovannoni, Christoph Roesli, Roberto Sommavilla, Giovannoni L, Villa A, Neri D, Sommavilla R, Pasche N, Kaspar M, Trachsel E, Roesli C   +24 more
core   +1 more source

Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom‐Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
First‐trimester trophoblast EVs are enriched in anti‐inflammatory proteins, lipids, and immunoregulatory miRNAs. EVT‐EVs reprogram monocytes toward a pro‐resolving phenotype and restore immune homeostasis in RDEB, supporting their potential as offering a scalable off‐the‐shelf therapy for chronic inflammatory diseases.
Nell Hirt, Enzo Manchon, Ming Wu, Helene Le Buanec, Pauline Bataille, Emmanuelle Bourrat, Jean‐David Bouaziz, Nabila Jabrane‐Ferrat, Reem Al‐Daccak   +8 more
wiley   +1 more source

Tumor therapy studies with IL12-SS1 (Fv).

, 2013
(A) Treatment of 8-week old female athymic nude mice with IL12-SS1 (Fv) after intraperitoneal injection of LMB-H226-GL. SS1P (0.4 mg/kg), IL12-SS1 (Fv) (0.4 mg/kg), IL12-SS1 (Fv) (1.6 mg/kg), or vehicle (PBS) were intraperitoneally injected times at days
Wei Gao (2085), Heungnam Kim (156424), Mitchell Ho (156431)   +2 more
core   +1 more source