Results 1 to 10 of about 5,357 (117)
Comparison of iloprost therapy versus non-iloprost therapy for severe frostbite: a retrospective cohort study of two Canadian cities [PDF]
BMJ OpenObjectives Frostbite is a common reason for emergency department (ED) presentations in Canada. Iloprost, a prostacyclin analogue, has been investigated to reduce the risk of amputation with its use expanding. Two Canadian cities implemented iloprost over
Jake Hayward +28 more
doaj +2 more sources
IL-4Rα signalling influences behavioural and immune responses in Trypanosoma brucei-infected mice: Evidence for iloprost as a neuroprotective agent [PDF]
IBRO Neuroscience ReportsThis study investigated the effects of Trypanosoma brucei infection on neuroinflammation, immune response, and behaviour in both wild-type (WT) and IL-4Rα inhibited (IL-4Rα┴) mice.
OS Olaolu +7 more
doaj +2 more sources
Endothelial‐Derived Extracellular Vesicles During Exercise in COPD Patients [PDF]
The Clinical Respiratory JournalIntroduction There are no treatments directly targeting the pulmonary vasculature in chronic obstructive pulmonary disease (COPD), and further characterization of the underlying endothelial cell (EC) abnormalities could be helpful in drug development ...
Samuel C. Okpechi +7 more
doaj +2 more sources
Applied Sciences, 2021 Purpose: The present study aims to assess the combined effects of mineral trioxide aggregate (MTA) and iloprost when used as a pulp capping material on pulpal inflammation and tertiary dentin formation compared with MTA and iloprost alone in rat molar ...
AlAnoud Almeshari +5 more
doaj +1 more source
Frontiers in Oncology, 2023 IntroductionIloprost, a prostacyclin analog, has lung cancerpreventive activity in preclinical models and improved dysplasia in former smokers in a phase IIb trial. Oral iloprost is currently unavailable. We performed a phase Ib trial of inhaled iloprost
York E. Miller +17 more
doaj +1 more source
Iloprost requires the Frizzled-9 receptor to prevent lung cancer
iScience, 2022 Summary: Prevention of premalignant lesion progression is a promising approach to reducing lung cancer burden in high-risk populations. Substantial preclinical and clinical evidence has demonstrated efficacy of the prostacyclin analogue iloprost for lung
Kayla Sompel +11 more
doaj +1 more source
Pulmonary Circulation, 2022 Inhaled iloprost is an established treatment for pulmonary arterial hypertension (PAH). However, the long‐term hemodynamic changes that inhaled iloprost induces are unclear.
Kenichiro Yasuda +5 more
doaj +1 more source
Acute effects of aerosolized iloprost in COPD related pulmonary hypertension - a randomized controlled crossover trial. [PDF]
PLoS ONE, 2012 BACKGROUND: Inhaled iloprost potentially improves hemodynamics and gas exchange in patients with chronic obstructive pulmonary disease (COPD) and secondary pulmonary hypertension (PH).
Lucas Boeck +3 more
doaj +1 more source
Protocol for intranasal chemoprevention delivery in a urethane mouse lung cancer model
STAR Protocols, 2022 Summary: Mouse iloprost lung cancer chemoprevention studies typically use oral delivery. Here, we present a protocol for intranasal iloprost delivery within a urethane lung adenocarcinoma mouse model.
Lori Dwyer-Nield +2 more
doaj +1 more source
Scientific Reports, 2022 Expression of Frizzled 9 (FZD9) is critical to the activity of the lung cancer chemoprevention agent and prostacyclin analogue, iloprost. FZD9 is required in lung epithelial cells for iloprost to activate peroxisome proliferator activated receptor gamma (
A. J. Smith +4 more
doaj +1 more source