Results 21 to 30 of about 7,843 (191)

Iloprost Duration for Digital Ulcers in Systemic Sclerosis: French Retrospective Study at Two Centers and Literature Review

Frontiers in Medicine, 2022
ObjectiveIschemic digital ulcers (DUs) are frequent and severe complications of systemic sclerosis (SSc). Treatment options for SSc-related digital vasculopathy are based on aggressive vasodilation, with the objective to improve blood flow in ischemic ...
Céline Jamart, Hervé Levesque, Sara Thietart, Olivier Fain, Sébastien Rivière, Ygal Benhamou, Arsène Mekinian, Arsène Mekinian   +7 more
doaj   +1 more source

Plasma Exosome Metabolomics Reveal Stage-Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome. [PDF]

Chronic Dis Transl Med
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Qian M, Nie D, Gao Q, Mo X, Zhang H.
europepmc   +2 more sources

Lung-Cardiovascular Interactions and Derangements in ARDS. [PDF]

Compr Physiol
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Sanchez PA, O'Brien C, Legrand M, Calfee CS, Matthay MA.   +4 more
europepmc   +2 more sources

Clinical Phenotypes, Treatment, and Outcomes of Rheumatic Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitors: A Rheumatologists-Referred Multicenter German Registry Cohort. [PDF]

ACR Open Rheumatol
Objective Immune checkpoint inhibitors (ICIs) induce a broad range of immune‐related adverse events (irAEs), including rheumatic manifestations. Evidence from dedicated rheumatology cohorts on the clinical spectrum, severity, treatment, and outcomes of rheumatic irAEs (rh‐irAEs) remains limited.
Gailis D, Ullrich FTH, Dombret S, Schmalzing M, Hasseli-Fräbel R, Witte T, Thiele T, Kiltz U, Oleszowsky M, Müller M, Gente K, Specker C, Thaler MB, Skapenko A, Schulze-Koops H.   +14 more
europepmc   +2 more sources

Use of Aerosolized Prostacyclins in Critically Ill Patients and Association With Clinical Outcomes

Critical Care Explorations, 2023
IMPORTANCE:. Aerosolized prostacyclins are frequently used in patients with severe acute respiratory distress syndrome and refractory hypoxia. Previous studies have shown improvement in oxygenation with use of pulmonary vasodilators such as iloprost and ...
S. Talal Hussain, MD, Huzaifa A. Jaliawala, MD, Daniel Zhao, PhD, Sardar Hassan Ijaz, MD, Janice Tsui, PharmD, BCPS, Bobby Chasteen, RRT, Brent R. Brown, MD, Roberto J. Bernardo, MD, MS   +7 more
doaj   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities. [PDF]

Compr Physiol
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Al Matni MY, Belvitch P, Dudek SM, Letsiou E.   +3 more
europepmc   +2 more sources

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients [PDF]

, 2001
Patients with scleroderma receiving Iloprost as a treatment for severe Raynaud's phenomenon report a reduction in skin tightness, suggesting that this drug inhibits skin fibrosis.
Stratton, R, Thomas Haberberger, Carol M. Black, Haberberger, T, Xu Shiwen, Martini, G, Holmes, A, Alan Holmes, Andrew Leask, Shiwen, X, David Abraham, Black, CM, Leask, A, Martin, GR, Abraham, D, George R. Martin, Richard Stratton, Giorgia Martini   +17 more
core   +1 more source

Inhaled iloprost is an effective alternative therapy for persistent pulmonary hypertension in newborns

Pulmonary Circulation, 2023
Persistent pulmonary hypertension of the newborn (PPHN) is one of the diseases of the neonate with severe potential morbidity and mortality. Inhaled iloprost, a stable prostacyclin analog, has been suggested as an alternative treatment for inhaled nitric
Şükran Yıldırım
doaj   +1 more source

Beneficial Effects of Iloprost on Acute Myocardial Ischemia in Dogs [PDF]

, 1994
1994-03-25The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary
IEDA, NOBUTO, SAKAMOTO, NOBUO, MATSUBARA, TATSUAKI   +2 more
core   +1 more source

Two Randomised and Placebo-controlled Studies of an Oral Prostacyclin Analogue (Iloprost) in Severe Leg Ischaemia [PDF]

, 2000
Two separate studies are described using the same prostacyclin analogue in a similar group of patients.Objectives: to assess the tolerability and efficacy of two dose regimens of oral Iloprost compared with placebo in the treatment of patients with ...
The Oral Iloprost in Severe Leg Ischaemia Study Group,
core   +1 more source