Results 71 to 80 of about 12,109,427 (256)

The Future of Image-guided Radiotherapy [PDF]

, 2017
Dose-escalated radiotherapy using increasingly con-formal techniques from three-dimensional conformal radiotherapy to step-and-shoot intensity-modulated radiotherapy (IMRT) through to volumetric-modulated arc therapy (VMAT) has been shown to improve ...
A. McWilliam, Budgell, G., Choudhury, A., A. Choudhury, R. MacKay, Faivre-Finn, C., Faivre-Finn, C.; id_orcid, MacKay, R., McWilliam, A., G. Budgell, Choudhury, A.; id_orcid, S. Falk, van Herk, M., M. Dubec, M. van Herk, Falk, S., van Herk, M.; id_orcid, Dubec, M., C. Faivre-Finn   +18 more
core   +1 more source

Image-guided radiotherapy in upper gastrointestinal malignancies: an Italian survey by the AIRO gastrointestinal study group

Oncologie
Image-guided radiation therapy (IGRT) plays a central role in modern radiotherapy. However, due to a lack of standardised guidelines for image acquisition, timing, and motion management protocols, considerable variation exists in clinical practice.
de Franco Paola, Galofaro Elena, De Renzi Filippo, De Felice Francesca, Famà Lia, Valenti Marco, Iosca Nicola, Pisoni Valerio, Votta Claudio, Cellini Francesco, Alaimo Rita, Montesi Giampaolo, Simoni Nicola, Lupattelli Marco, Mantello Giovanna, Niespolo Rita M.   +15 more
doaj   +1 more source

Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the shorter-term curative efficacy and safety of whole brain radio therapy(WBRT) combined with simultaneous integrated boost versus sequential integrated boost using image-guided intensity-modulated radiotherapy (IG-IMRT) for ...
HE Jun, ZHANG Chengda, JIA Lin, HAN Jianjun, GAO Fei, WANG Yun, JIA Li, JIA Dong, CHEN Yan   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Image-Guided Orthopaedic Surgery [PDF]

, 2013
Image-guided surgery systems are increasingly being used during orthopaedic interventions. The aim of this chapter is to present the basic elements of these image-guided orthopaedic surgery (IGOS) devices and to review examples of preoperative or intra ...
Nolte, Lutz-Peter, Zheng, Guoyan, Lutz-P. Nolte, Guoyan Zheng   +3 more
core   +1 more source

Prostate Radiotherapy in the Era of Advanced Imaging and Precision Medicine

Prostate Cancer, 2016
Tremendous technological advancements in prostate radiotherapy have decreased treatment toxicity and improved clinical outcomes for men with prostate cancer.
Caleb R. Dulaney, Daniel O. Osula, Eddy S. Yang, Soroush Rais-Bahrami   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Target coverage in image-guided stereotactic body radiotherapy of liver tumors

, 2007
PURPOSE: To determine the effect of image-guided procedures (with computed tomography [CT] and electronic portal images before each treatment fraction) on target coverage in stereotactic body radiotherapy for liver patients using a stereotactic body ...
Vásquez Osorio, Eliana M; id_orcid, Heijmen, Ben J M, Heijmen, Ben, Brandwijk, Rene, Méndez Romero, Alejandra, Wunderink, Wouter, Levendag, Peter, Brandwijk, René P, Levendag, Peter C, Vasquez Osorio, Eliana, Boer, Hans, de Boer, Hans C J   +11 more
core   +1 more source

MRI-Guided Radiotherapy for Prostate Cancer: a New Paradigm

Acta Clinica Croatica, 2022
Radiotherapy is one of the key treatment modalities for primary prostate cancer. During the last decade, significant advances were made in radiotherapy technology leading to increasing both physical and biological precision.
Jure Murgić, Marin Gregov, Iva Mrčela, Mirjana Budanec, Marco Krengli, Ana Fröbe, Pierfrancesco Franco   +6 more
doaj