Results 51 to 60 of about 920,743 (333)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Imaginary and Symbolic Forms of Water between Spirit and Culture
Academicus International Scientific JournalWater is a theme connected to human and social development, not only biologically but also in terms of cultural and identity processes; surprisingly, studies that discuss water from a sociocultural/sociological perspective are scarce.
Eleonora Sparano, Nicola Strizzolo
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Bulletin de l’Association de Géographes FrançaisSaint-Étienne, an industrial stronghold until 1918 before becoming an area in crisis, has drawn its roots and its identity from its underground. Today, its landscape reveals not only the traces of this unique industrial epic, but also the signs of its ...
Georges-Henry Laffont, Luc Rojas
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L’immaginario politico delle memorie: Brasile 1964-1985 [PDF]
Diacronie. Studi di Storia Contemporanea, 2016 From the numerous forms of symbolic good produced in Brazil and pertaining to the period of the dictatorship, itself a stimulus for political commemoration and constant subject of debate, we have chosen to concentrate on the analysis of books, considered
Lucileide Costa Cardoso
doaj
Antiproton-deuteron annihilation at low energies
, 2000 Recent experimental studies of the antiproton-deuteron system at low energies have shown that the imaginary part of the antiproton-deuteron scattering length is smaller than the antiproton-proton one.
A. Yu. Voronin +22 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Kinetic description of the oblique propagating spin-electron acoustic waves in degenerate plasmas
, 2017 Oblique propagation of the spin-electron acoustic waves in degenerate magnetized plasmas is considered in terms of quantum kinetics with the separate spin evolution, where the spin-up electrons and the spin-down electrons are considered as two different ...
Andreev, Pavel A.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Time and chaos: the “imagination of possibilities” and the media
Comunicação e Sociedade, 2019 This article proposes a reflection about the notion of time and its relation to the media based on the complex thinking paradigm and the transdisciplinary perspective.
Gustavo Castro, Florence Dravet
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