Results 101 to 110 of about 190,121 (278)

PD01-03 CHARACTERIZING THE IMMUNE AND INFLAMMATORY MICROENVIRONMENTS OF HUNNER LESIONS IN INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME WITH IMAGING MASS CYTOMETRY: A NEW LOOK AT AN OLD DISEASE [PDF]

, 2021
Tiziana Cotechini, Sindhura Thirumal, Charlie Hindmarch, Parvin Mousavi, David J. Berman, D. Robert Siemens, J. Curtis Nickel, Charles E. Graham, R. Christopher Doiron   +8 more
openalex   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il. Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Oligonucleotide-polymer conjugation for imaging mass cytometry v2 [PDF]

, 2023
Danielschulz not provided
openalex   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

TICAL - a web-tool for multivariate image clustering and data topology preserving visualization [PDF]

, 2011
In life science research bioimaging is often used to study two kinds of features in a sample simultaneously: morphology and co-location of molecular components.
Abouna, Sylvie, Khan, Michael, Kölling, Jan, Langenkämper, Daniel, Nattkemper, Tim W., Niehaus, Karsten   +5 more
core  

Laser‐Microscribed Glass Enables Surface‐Microfluidics‐Facilitated, Affordable, Rapid Cancer Diagnosis

Advanced Functional Materials, EarlyView.
A transparent, laser‐microscribed glass platform enables cancer diagnosis within 1 h—much faster than histology, which takes days, and free from the chemical or contrast risks of MRI or CT scans. The antibody‐functionalized rough glass surface captures viable cancer cells directly from suspension, allowing instant optical readout and offering a rapid ...
Anish Pal, Snehasis Mishra, Arani Mukhopadhyay, Ilias Papailias, Atique U. Ahmed, Constantine M. Megaridis   +5 more
wiley   +1 more source

Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response

Metabolites
A multimodal mass spectrometry imaging (MSI) approach was used to investigate the chemotherapy drug-induced response of a Multicellular Tumour Spheroid (MCTS) 3D cell culture model of osteosarcoma (OS). The work addresses the critical demand for enhanced
Sophie M. Pearce, Neil A. Cross, David P. Smith, Malcolm R. Clench, Lucy E. Flint, Gregory Hamm, Richard Goodwin, James I. Langridge, Emmanuelle Claude, Laura M. Cole   +9 more
doaj   +1 more source

Characterization of the Tumor Immune Microenvironment in Lung Squamous Cell Carcinoma Using Imaging Mass Cytometry

, 2021
Ran Li, Ying Lin, Yu Wang, Shaoyuan Wang, Yang Yang, Xinlin Mu, Yusheng Chen, Zhancheng Gao   +7 more
openalex   +1 more source

Unraveling the Heterogeneity of Cargo Distribution in the Exogenous Association of Proteins With Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
We characterized the distribution of cargo proteins associated with extracellular vesicles using various exogenous loading methods. In all cases, single‐particle analysis revealed that the distribution of protein content per EV is heterogeneous, following an exponential decay function.
Karl Normak, Marcell Papp, Carolina Paganini, Andrea Zendrini, Paolo Bergese, Dorothea Pinotsi, Paolo Arosio   +6 more
wiley   +1 more source

Methods for Analyzing Imaging Mass Cytometry Data with Tellurium Probes [PDF]

, 2019
Jay Bassan, Mark Nitz
openalex   +1 more source