Results 81 to 90 of about 5,090,386 (280)

Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison

, 2021
Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad range of compounds and, therefore, is frequently applied in the pharmaceutical industry.
Vreeken, Rob J., Flinders, Bryn, Heeren, Ron M. A., Porta Siegel, Tiffany, Vreeken, Rob J.; id_orcid, Hadavi, Darya, Viehmann, Brent, Lamont, Lieke   +7 more
core   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Imaging Mass Cytometry Compensation Slide Preparation v1 [PDF]

, 2020
This SOP describes the preparation of compensation slides with single antibodyconjugate spots that can be used to estimate mass channel spillover for IMC. Spillover varies from metal lot to lot due to varying impurities. Once a spillover matrix for a specific set of antibody-conjugates has been generated, the experiment of interest, in which the same ...
Michelle Daniel, Marda Jorgensen
openaire   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

MALDI Mass Spectrometry Imaging in Microscope Mode with Infrared Lasers: Bypassing the Diffraction Limits

, 2014
This letter demonstrates the use of infrared matrix-assisted laser desorption/ionization coupled with microscope mode mass spectrometry imaging. It is aimed to explore the use of intrinsic water in tissue as a matrix for imaging at spatial resolutions ...
Soltwisch, Jens, Smith, Donald F., Ellis, Shane R., Heeren, Ron M. A., Goeritz, Guido, Jungmann, Julia H., Kiss, Andras   +6 more
core   +1 more source

Visualizing molecular distributions for biomaterials applications with mass spectrometry imaging: a review [PDF]

, 2017
Mass spectrometry imaging (MSI) is a rapidly emerging field that is continually finding applications in new and exciting areas. The ability of MSI to measure the spatial distribution of molecules at or near the surface of complex substrates makes it an ...
Shane R. Ellis, Martin R. L. Paine, Heeren, Ron M. A., Ellis, Shane R., Gregory L. Fisher, Kooijman, Pieter C., Fisher, Gregory L., Facundo M. Fernández, Pieter C. Kooijman, Paine, Martin R. L., Ron M. A. Heeren, Fernandez, Facundo M.   +11 more
core   +2 more sources

Volatile Relay Biosensing and Mobile Phone Imaging for Detection of Influenza Virus

Advanced Functional Materials, EarlyView.
Detection of volatile organic compounds is performed via a coupled enzymatic assay with mobile phone detection of the signal. Specific application demonstrated herein is the detection of influenza virus, across multiple levels of biological complexity, up to patient‐derived samples.
Dante G. Andersen, Josefine H. Jakobsen, Mikkel Høj Nielsen, Shreyans Chatterjee, Detlef Michel, Jan Münch, Rüdiger Gross, Alexander N. Zelikin   +7 more
wiley   +1 more source

Mass Spectrometry Imaging with Isomeric Resolution Enabled by Ozone-Induced Dissociation

, 2018
Mass spectrometry imaging (MSI) enables the spatial distributions of molecules possessing different mass-to-charge ratios to be mapped within complex environments revealing regional changes at the molecular level.
Poad, Berwyck L. J., Heeren, Ron M. A., Eijkel, Gert B., Marshall, David L., David L. Marshall, Ron M. A. Heeren, Shane R. Ellis, Martin R. L. Paine, Ellis, Shane R., Stephen J. Blanksby, Berwyck L. J. Poad, Gert B. Eijkel, Paine, Martin R. L., Blanksby, Stephen J.   +13 more
core   +1 more source

Mass spectrometry imaging for clinical research - latest developments, applications, and current limitations [PDF]

, 2017
Mass spectrometry is being used in many clinical research areas ranging from toxicology to personalized medicine. Of all the mass spectrometry techniques, mass spectrometry imaging (MSI), in particular, has continuously grown towards clinical acceptance.
Heeren, Ron M. A., Tiffany Porta, Pierre-Maxence Vaysse, Benjamin Balluff, Vaysse, Pierre-Maxence, Porta, Tiffany, Balluff, Benjamin, Ron M. A. Heeren   +7 more
core   +2 more sources

Enabling Indium Channels for Mass Cytometry by Using Reinforced Cyclambased Chelating Polylysine [PDF]

, 2020
A metal containing polymer (MCP) based on a polylysine functionalized by In(III) chelates was synthesized. The chelator is based on a constrained dipicolinate cyclam that forms a highly inert In(III) complex.
Raphael, Tripier, Maryline, Beyler, Peng, Liu, Nick, Zabinyakov, olga, ornatsky, Taunia L. L., Closson, Laura, Grenier, Jothir Mayanantham, Pichaandi, Mitchell A., Winnik, Yefeng, Zhang, Alexandre, Bouzekri, Vladimir, Baranov   +11 more
core   +1 more source