Results 91 to 100 of about 5,090,386 (280)

Sulfation‐Tunable Peptide‐Glycosaminoglycan Hydrogels for Hematopoietic Stem and Progenitor Cell Expansion

Advanced Functional Materials, EarlyView.
Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik, Prannoy Seth, Maximilian Fusenig, Jens Friedrichs, Nicole Fertala, Passant Atallah, Uwe Freudenberg, Ayala Lampel, Carsten Werner   +8 more
wiley   +1 more source

Gold Sputtered Fiducial Markers for Combined Secondary Ion Mass Spectrometry and MALDI Imaging of Tissue Samples

, 2014
Mass spectrometry imaging (MSI) is a label free technique capable of providing simultaneous identification and localization of biomolecules. A multimodal approach is required that allows for the study of the complexity of biological tissue samples to ...
Flinders, Bryn, Heeren, Ron M. A., Pelicon, Primoz, Skraskova, Karolina, Potocnik, Nina Ogrinc   +4 more
core   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Multiplex Stimulated Raman Scattering Imaging Cytometry Reveals Lipid-Rich Protrusions in Cancer Cells under Stress Condition

iScience, 2020
Summary: In situ measurement of cellular metabolites is still a challenge in biology. Conventional methods, such as mass spectrometry or fluorescence microscopy, would either destroy the sample or introduce strong perturbations to target molecules. Here,
Kai-Chih Huang, Junjie Li, Chi Zhang, Yuying Tan, Ji-Xin Cheng   +4 more
doaj   +1 more source

Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments linked to immunotherapy responses in melanoma

Communications Medicine, 2022
Xiao, Guo et al. use imaging mass cytometry to evaluate the spatial composition of the tumor microenvironment in melanoma. The authors identify features of the microenvironment associated with response to anti-PD-1 immunotherapy.
Xu Xiao, Qian Guo, Chuanliang Cui, Yating Lin, Lei Zhang, Xin Ding, Qiyuan Li, Minshu Wang, Wenxian Yang, Yan Kong, Rongshan Yu   +10 more
doaj   +1 more source

Imaging Isomers on a Biological Surface:A Review

, 2019
Mass spectrometry imaging is an imaging technology that allows the localization and identification of molecules on (biological) sample surfaces. Obtaining the localization of a compound in tissue is of great value in biological research.
Shimma, Shuichi, Fukusaki, Eiichiro, Claes, Britt S R, Heeren, Ron M A, Takeo, Emi   +4 more
core   +1 more source

Biomimetic Core–Shell Liposome Nanoparticles Deplete Lipoproteins and Enhance the Purity of Extracellular Vesicles from Human Blood

Advanced Functional Materials, EarlyView.
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang, Andrew J. Perciaccante, David Inman, Bong Hwan Sung, Alissa M. Weaver, Suzanne M. Ponik, Ying Ge, Song Jin   +7 more
wiley   +1 more source

ImmuVis: Hyperconvolutional Foundation Model for Imaging Mass Cytometry

CoRR
We present ImmuVis, a family of efficient foundation models for imaging mass cytometry (IMC), a high-throughput multiplex imaging technology that handles molecular marker measurements as image channels and enables large-scale spatial tissue profiling. Unlike natural images, multiplex imaging lacks a fixed channel space, as real-world marker sets vary ...
Marcin Mozejko, Dawid Uchal, Krzysztof Gogolewski, Piotr Kupidura, Szymon Lukasik, Jakub Giezgala, Tomasz Nocon, Kacper Pietrzyk, Robert Pieniuta, Mateusz Sulimowicz, Michal Orzylowski, Tomasz Silkowski, Karol Zagródka, Eike Staub, Ewa Szczurek   +14 more
openaire   +3 more sources

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches [PDF]

, 2019
Desorption electrospray ionisation-mass spectrometry imaging (DESI-MSI) is a powerful imaging technique for the analysis of complex surfaces. However, the often highly complex nature of biological samples is particularly challenging for MSI approaches ...
Tsybin, YO, Heeren, Ron M. A., Kooijman, Pieter C., Ellis, SR, Kozhinov, Anton N., Nagornov, KO, Heeren, RMA, Kilgour, David P. A., Kilgour, DPA, Ellis, Shane R., Kozhinov, AN, Nagornov, Konstantin O., Kooijman, PC, Tsybin, Yury O.   +13 more
core   +1 more source

Hierarchical Collagen Nanofiber Gels Recapitulate a Physiologically Relevant Tumor Stromal Microenvironment

Advanced Healthcare Materials, EarlyView.
The collagen nanofiber (CNF) gel supports cancer cell culture, exhibiting cell morphology and cancer‐related protein expression similar to Matrigel. It offers a higher collagen concentration than commercial gels. Additionally, the CNF gel allows replication of the high elasticity of in vivo cancer tissue by controlling collagen fiber sizes, ranging ...
Naoko Sasaki, Tomoyuki Suezawa, Shiro Kitano, Ryohei Katayama, Michiya Matsusaki   +4 more
wiley   +1 more source