Results 71 to 80 of about 141,877 (234)

Semi-automated background removal limits data loss and normalizes imaging mass cytometry data

, 2021
Imaging mass cytometry (IMC) allows the detection of multiple antigens (approximately 40 markers) combined with spatial information, making it a unique tool for the evaluation of complex biological systems. Due to its widespread availability and retained
de Miranda, Noel F. C. C., Boudewijn P. F. Lelieveldt, Lelieveldt, B.P.F. (author), Höllt, T. (author), Thomas Höllt, Lelieveldt, Boudewijn P. F., Somarakis, A., Somarakis, Antonios (author), Lelieveldt, B.P.F., Ijsselsteijn, Marieke E., Somarakis, Antonios, Antonios Somarakis, Höllt, Thomas, Höllt, T., Miranda, N.F.C.C., Ijsselsteijn, Marieke E. (author), de Miranda, Noel F. C. C. (author), Noel F. C. C. de Miranda, IJsselsteijn, M.E., Marieke E. Ijsselsteijn   +19 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Imaging mass cytometry data: Diffuse large B-cell lymphoma lymph node section

, 2021
High dimensional cytometry is an innovative tool for immune monitoring in health and disease, it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases.
Timms, Jessica, Mourikis, Thanos, Kareemaghay, Sedigeh, Kordasti, Shahram, Nocerino, Paola, Barber, Paul, Chapuis, Nicolas, Ramsay, Alan, Harrison, Claire, Parker, Peter, Tavassoli, Mahvash, Opzoomer, James, Apollonio, Benedetta, Fontenay, Michaela, Arnold, James, Ciccarelli, Francesca, Blighe, Kevin, Bekoe, Richard   +17 more
core   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Immunogenomics of colorectal cancer response to immune checkpoint blockade: Imaging Mass Cytometry

, 2020
Immunogenomics of colorectal cancer response to immune checkpoint blockade Imaging Mass Cytometry data supporting the paper: "Immunogenomics of colorectal cancer response to immune checkpoint blockade" The provided data includes: Sample metadata ...
Katrina, Todd, Shiu, Kai-Keen, Wilson, Gareth A., Montorsi, Lucia, Temelkovski, Damjan, Rodriguez-Justo, Manuel, Spencer, Jo, Nedyalko, Petrov, John, Susan, Bortolomeazzi, Michele, Swanton, Charles, Keddar, Mohamed Reda, Al Bakir, Maise, Benedetti, Lorena, Parker, Peter, Ward, Sophia, Miles, James, Larijani, Banafshe, Choi, Subin, Ciccarelli, Francesca D.   +19 more
core   +1 more source

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Ultrafast Microfluidic Cellular Imaging by Optical Time Stretch

, 2016
There is an unmet need in biomedicine for measuring a multitude of parameters of individual cells (i.e., high content) in a large population ef ciently (i.e., high throughput).
Shum, Ho Cheung, Wong, TTW, Lau, Andy K.S., Wong, KKY, Shum, HC, Tsia, KKM, Tsia, Kevin K., Wong, Terence T.W., Lau, AKS, Wong, Kenneth K.Y.   +9 more
core   +1 more source