Results 41 to 50 of about 190,121 (278)

Fluorescence Correlation Spectroscopy Reveals Efficient Cytosolic Delivery of Protein Cargo by Cell-Permeant Miniature Proteins. [PDF]

, 2018
New methods for delivering proteins into the cytosol of mammalian cells are being reported at a rapid pace. Differentiating between these methods in a quantitative manner is difficult, however, as most assays for evaluating cytosolic protein delivery are
Knox, Susan L, Schepartz, Alanna, Steinauer, Angela, Thompson, Alexander D, Wissner, Rebecca F   +4 more
core   +2 more sources

Comparison of Osteosarcoma Aggregated Tumour Models with Human Tissue by Multimodal Mass Spectrometry Imaging

Metabolites, 2021
Osteosarcoma (OS) is the most common primary bone malignancy and largely effects adolescents and young adults, with 60% of patients under the age of 25. There are multiple cell models of OS described in vitro that express the specific genetic alterations
Lucy E. Flint, Gregory Hamm, Joseph D. Ready, Stephanie Ling, Catherine J. Duckett, Neil A. Cross, Laura M. Cole, David P. Smith, Richard J. A. Goodwin, Malcolm R. Clench   +9 more
doaj   +1 more source

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. [PDF]

, 2018
Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of
Avanzi, Mauro P, Brentjens, Renier J, Cheung, Kenneth, Daniyan, Anthony F, Li, Xinghuo, Park, Hyebin, Purdon, Terence J, Spitzer, Matthew H, van Leeuwen, Dayenne G, Wijewarnasuriya, Dinali P, Yeku, Oladapo   +10 more
core   +1 more source

Novel Techniques and Future Perspective for Investigating Critical-Size Bone Defects

Bioengineering, 2022
A critical-size bone defect is a challenging clinical problem in which a gap between bone ends will not heal and will become a nonunion. The current treatment is to harvest and transplant an autologous bone graft to facilitate bone bridging.
Elijah Ejun Huang, Ning Zhang, Huaishuang Shen, Xueping Li, Masahiro Maruyama, Takeshi Utsunomiya, Qi Gao, Roberto A. Guzman, Stuart B. Goodman   +8 more
doaj   +1 more source

Advances in mass cytometry and its applicability to digital pathology in clinical-translational cancer research

Advances in Laboratory Medicine, 2021
The development and subsequent adaptation of mass cytometry for the histological analysis of tissue sections has allowed the simultaneous spatial characterization of multiple components.
Cereceda Karina, Jorquera Roddy, Villarroel-Espíndola Franz   +2 more
doaj   +1 more source

Single-Cell Analysis of Refractory Celiac Disease Demonstrates Inter- and Intra-Patient Aberrant Cell HeterogeneitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Refractory celiac disease type II (RCDII) is a rare indolent lymphoma in the small intestine characterized by a clonally expanded intraepithelial intracellular CD3+surfaceCD3-CD7+CD56- aberrant cell population.
Tessa Dieckman, Mette Schreurs, Ahmed Mahfouz, Yvonne Kooy-Winkelaar, Andra Neefjes-Borst, Gerd Bouma, Frits Koning   +6 more
doaj   +1 more source

Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. [PDF]

, 2012
PurposeAs imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody ...
Braun, Jonathan, Brewer, Sarah, Fu, Maoyong, Gordon, Lynn K, Olafsen, Tove, Said, Jonathan, Wadehra, Madhuri, Wu, Anna M   +7 more
core   +3 more sources

Metal Isotope-Tagged Nanomaterials for Mass Cytometry and Imaging: Advances and Biomedical Applications

Nano Biomedicine and Engineering
Mass cytometry (cytometry by time-of-flight (CyTOF)) and imaging mass cytometry (IMC) are transformative technologies that combine flow cytometry principles with time-of-flight mass spectrometry (TOF-MS).
Dongling Jia, Minhui Cui, Weiwei Wang, Jielin Sun, Xiaoxiang Chen   +4 more
doaj   +1 more source

The effects of aggregation and protein corona on the cellular internalization of iron oxide nanoparticles

, 2011
Engineered inorganic nanoparticles are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids.
Berret, J. -F., Conjeaud, H., Courtois, J., Safi, M., Seigneuret, M.   +4 more
core   +2 more sources

3D printing for bio-synthetic biliary stents [PDF]

, 2019
Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies.
Alexander, Jonathan Steven, Ballard, David, Boktor, Moheb, Boktor, Moheb, Boyer, Christen J., Ghali, G.E., Huebert, Robert, Samant, Hrishikesh, Wang, Yuping, White, Luke, Woerner, Jennifer E.   +10 more
core   +2 more sources