Results 121 to 130 of about 81,920,088 (159)

Recent Progress in the Pharmacology of Imidazo[1,2-a]pyridines

Mini-Reviews in Medicinal Chemistry, 2007
Imidazo[1,2-a]pyridine is a bicyclic system with a bridgehead nitrogen atom, of growing interest in medicinal chemistry. The paper deals with the recent progress realised in the comprehension of the pharmacological properties of this scaffold. From the many imidazo[1,2-a]pyridine analogues described in the literature, those discussed herein will be ...
Cécile, Enguehard-Gueiffier, Alain, Gueiffier   +1 more
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Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines

Bioorganic & Medicinal Chemistry, 2008
The key dinitrile intermediates 4a-d were synthesized by reaction of phenacyl bromide 1 and the appropriate 2-amino-5-bromopyridines to yield 3a-d. Suzuki coupling of 3a-d with 4-cyanophenylboronic acid yielded the 2,6-bis(4-cyanophenyl)-imidazo[1,2-a]pyridine derivatives 4a-d. The bis-amidoximes 5a-d, obtained from 4a-d by the action of hydroxylamine,
Mohamed A, Ismail, Reem K, Arafa, Tanja, Wenzler, Reto, Brun, Farial A, Tanious, W David, Wilson, David W, Boykin   +6 more
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Imidazo[1,2-a]pyridines with potent activity against herpesviruses

Bioorganic & Medicinal Chemistry Letters, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kristjan S, Gudmundsson, Brian A, Johns
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Synthesis of imidazo[1,2- a] pyridines directly from methyl or methylene ketones. iodination of imidazo[1,2-a] pyridines

Chemistry of Heterocyclic Compounds, 1976
Imidazo[1,2-a]pyridines were obtained by direct reaction of acetophenone, propiophenone, and their furan analogs and ring-substituted derivatives with an equimolar amount of iodine and and excess 2-aminopyridine or its substituted derivatives. The effect of substituents in the ketones and 2-aminopyridine, the reagent molar ratios, the character of the ...
N. O. Saldabol, S. A. Giller
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Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents

Arzneimittelforschung, 2011
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From
S, Mavel, J L, Renou, C, Galtier, R, Snoeck, G, Andrei, J, Balzarini, E, De Clercq, A, Gueiffier   +7 more
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Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists

Bioorganic & Medicinal Chemistry Letters, 2009
A series of imidazo[1,2-a]pyridine derivatives was identified and evaluated for MCH1R binding and antagonistic activity. Introduction of a methyl substituent at the 3-position of imidazo[1,2-a]pyridine provided compounds with a significant improvement in MCH1R affinity.
Hiroyuki, Kishino, Minoru, Moriya, Shunji, Sakuraba, Toshihiro, Sakamoto, Hidekazu, Takahashi, Takao, Suzuki, Ryuichi, Moriya, Masahiko, Ito, Hisashi, Iwaasa, Norihiro, Takenaga, Akane, Ishihara, Akio, Kanatani, Nagaaki, Sato, Takehiro, Fukami   +13 more
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Medicinal Attributes of Imidazo[1,2-a]pyridine Derivatives: An Update

Current Topics in Medicinal Chemistry, 2016
The imidazo[1,2-a]pyridine scaffold is recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several commercial drugs such as Zolpidem, Olprinone, Soraprazan and many other compounds in biological testing and preclinical evaluation, illustrate ...
Nisha, Devi, Dharmender, Singh, Ravindra K, Rawal, Jitender, Bariwal, Virender, Singh   +4 more
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ChemInform Abstract: Imidazo(1,2‐a)pyridines. Part 2. Ozonolysis of Imidazo(1,2‐a)pyridines and Synthesis of Cardiotonic Agents.

ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. YAMANAKA, S. SUDA, N. YONEDA, H. OHHARA   +3 more
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Imidazo[1,2-a]pyridine Scaffold as Prospective Therapeutic Agents

Current Topics in Medicinal Chemistry, 2016
Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5-6 heterocyclic rings that is recognized as a "drug prejudice" scaffold due to its broad range of applications in medicinal chemistry such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic, proton pump inhibitor, insecticidal activities.
Aakash, Deep, Richa Kaur, Bhatia, Ramanjot, Kaur, Sanjiv, Kumar, Upendra Kumar, Jain, Harinder, Singh, Sandeep, Batra, Dinesh, Kaushik, Pran Kishore, Deb   +8 more
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ChemInform Abstract: Diastereoisomeric Imidazo(1,2‐a)pyridines.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. KUBIK, J. NEMECEK, S. BOEHM, M. HRADILEK, J. KUTHAN   +4 more
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