Results 121 to 130 of about 1,977 (163)

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines

Bioorganic & Medicinal Chemistry, 2008
The key dinitrile intermediates 4a-d were synthesized by reaction of phenacyl bromide 1 and the appropriate 2-amino-5-bromopyridines to yield 3a-d. Suzuki coupling of 3a-d with 4-cyanophenylboronic acid yielded the 2,6-bis(4-cyanophenyl)-imidazo[1,2-a]pyridine derivatives 4a-d. The bis-amidoximes 5a-d, obtained from 4a-d by the action of hydroxylamine,
Mohamed A, Ismail, Reem K, Arafa, Tanja, Wenzler, Reto, Brun, Farial A, Tanious, W David, Wilson, David W, Boykin   +6 more
openaire   +2 more sources

ChemInform Abstract: Diastereoisomeric Imidazo(1,2‐a)pyridines.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. KUBIK, J. NEMECEK, S. BOEHM, M. HRADILEK, J. KUTHAN   +4 more
openaire   +1 more source

Synthesis of imidazo[1,2-a]pyridines: a decade update

Chemical Communications, 2015
Here we describe the various strategies for the synthesis of imidazo[1,2-a]pyridines.
Avik Kumar, Bagdi, Sougata, Santra, Kamarul, Monir, Alakananda, Hajra   +3 more
openaire   +2 more sources

Synthesis of imidazo[1,2- a] pyridines directly from methyl or methylene ketones. iodination of imidazo[1,2-a] pyridines

Chemistry of Heterocyclic Compounds, 1976
Imidazo[1,2-a]pyridines were obtained by direct reaction of acetophenone, propiophenone, and their furan analogs and ring-substituted derivatives with an equimolar amount of iodine and and excess 2-aminopyridine or its substituted derivatives. The effect of substituents in the ketones and 2-aminopyridine, the reagent molar ratios, the character of the ...
N. O. Saldabol, S. A. Giller
openaire   +1 more source

Imidazo[1,2-a]pyridine Scaffold as Prospective Therapeutic Agents

Current Topics in Medicinal Chemistry, 2016
Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5-6 heterocyclic rings that is recognized as a "drug prejudice" scaffold due to its broad range of applications in medicinal chemistry such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic, proton pump inhibitor, insecticidal activities.
Aakash, Deep, Richa Kaur, Bhatia, Ramanjot, Kaur, Sanjiv, Kumar, Upendra Kumar, Jain, Harinder, Singh, Sandeep, Batra, Dinesh, Kaushik, Pran Kishore, Deb   +8 more
openaire   +2 more sources

ChemInform Abstract: Imidazo(1,2‐a)pyridines. Part 2. Ozonolysis of Imidazo(1,2‐a)pyridines and Synthesis of Cardiotonic Agents.

ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. YAMANAKA, S. SUDA, N. YONEDA, H. OHHARA   +3 more
openaire   +1 more source

Organotin(IV) complexes with imidazo[1,2-a]pyridines

Polyhedron, 2014
Abstract The three-components reaction of dimethyltin dibromide with imidazo[1,2-a]pyridine and allyl bromide in ethanol affords an ionic complex, bis(1-allylimidazo[1,2-a]pyridinium) dimethyltetrabromostannate(II). X-ray crystal structure analysis of the complex reveals the tin atom to be hexacoordinated, forming a dianion.
Rati Agrawal, Varsha Goyal, Raakhi Gupta, Raghavaiah Pallepogu, Ramesh Kotikalapudi, Peter G. Jones, Raj K. Bansal   +6 more
openaire   +1 more source

ChemInform Abstract: Photoisomerization of Imidazo(1,2‐a)pyridines.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. KUBIK, S. BOEHM, V. HAVLICEK, J. KUTHAN   +3 more
openaire   +1 more source

Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists

Bioorganic & Medicinal Chemistry Letters, 2009
A series of imidazo[1,2-a]pyridine derivatives was identified and evaluated for MCH1R binding and antagonistic activity. Introduction of a methyl substituent at the 3-position of imidazo[1,2-a]pyridine provided compounds with a significant improvement in MCH1R affinity.
Hiroyuki, Kishino, Minoru, Moriya, Shunji, Sakuraba, Toshihiro, Sakamoto, Hidekazu, Takahashi, Takao, Suzuki, Ryuichi, Moriya, Masahiko, Ito, Hisashi, Iwaasa, Norihiro, Takenaga, Akane, Ishihara, Akio, Kanatani, Nagaaki, Sato, Takehiro, Fukami   +13 more
openaire   +2 more sources

Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents

Arzneimittelforschung, 2011
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From
S, Mavel, J L, Renou, C, Galtier, R, Snoeck, G, Andrei, J, Balzarini, E, De Clercq, A, Gueiffier   +7 more
openaire   +2 more sources