Results 121 to 130 of about 196,937 (296)
Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
Advanced Science, EarlyView.Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park +13 more
wiley +1 more source
Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer +17 more
wiley +1 more source
α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, EarlyView.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel +10 more
wiley +1 more source
2-Methoxy-1-methyl-4-nitro-1H-imidazole
, 2007 The molecule of the title compound, C5H7N3O3, is approximately planar. The maximum deviation from the least-squares plane calculated for all non-H atoms is 0.054 (2) Å.
Maciej Kubicki (832465) +1 more
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One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections
Advanced Science, EarlyView.Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong +11 more
wiley +1 more source
1-(4-Chlorophenyl)-2-methyl-4-nitro-5-(1-piperidyl)-1H-imidazole
, 2005 The only specific interactions that influence the crystal packing of the title compound, C15H17ClN4O2, are weak C-H...N and C-H...Cl hydrogen bonds, even though there is a possibility of, for example, pi-pi stacking or halogen bonding. The dihedral angle
Maciej Kubicki (832465) +1 more
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, 2016 Diethyl 5-amino-1-(p-methoxybenzyl)imidazole-2,4-dicarboxylate (3b) has been prepared from ethyl 2-amino-2-cyanoacetate and ethyl 1- ethoxycarbonyformimidate hydrochloride or ethyl triethoxyacetate followed by reaction with p-methoxybenzy lamine.
core +1 more source
Advanced Science, EarlyView.Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta +6 more
wiley +1 more source
Synthesis and polymerization of substituted imidazole chromophores, 1996 [PDF]
Four new functionalized imidazole chromophores, l-(vinylbenzyl)-2-(4'-nitrophenyl)-4,5-bis(4'-methoxyphenyl)imidazole, l-( 1 '-oxo-2'-methylethenyl)-2-(4'-nitrophenyl)-4,5-bis-(4'-methoxyphenyl)imidazole, l-(2'-propenyl)-2-(4'-nitrophenyl)-4,5-bis(4 ...
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