Results 201 to 210 of about 303,026 (334)

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Crystal structure of tris-[hexa-kis-(imidazole)cobalt(II)] bis-(benzene-1,3,5-tri-carboxyl-ate). [PDF]

Acta Crystallogr E Crystallogr Commun
Velazquez-Garcia JJ, Bintas C, Khademhir F, Knjo B, Ekineken A, Hain F, Techert S.   +6 more
europepmc   +1 more source

Psychopharmacological effects of a new antipsychotic, 1-[1-{3-(4-fluorobenzoyl)propyl}-4-piperidyl]-2,3-dihydrobenz-imidazole-2-thione (DD-3480)

, 1977
Terukiyo Yamasaki, Takeo Sakurai, Hiroshi Kojima, Akira Kasahara   +3 more
openalex   +1 more source

Cadmium-Imidazole Complex Formation in Aqueous Solutions. Stability Constants, Changes in Standard Free Energies, Enthalpies, Entropies, and Heat Capacities Accompanying the Complex Formation at 5, 15, 25, and 40 degrees C. [PDF]

, 1975
Jørgen B. Jensen, Erik Grønn Iversen, Bernt Klewe, Mats Granberg, Fred Karlsson, Kaj Edlund, Mogens Eliasen, Carsten Herskind, Thomas Laursen, Poul Møller Pedersen   +9 more
openalex   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Imidazole-2-thione derivatives as new selective anticancer agents with anti-metastatic properties: synthesis and pharmacological evaluation. [PDF]

J Enzyme Inhib Med Chem
Golcienė B, Maciejewska N, Kallingal A, Sapijanskaitė-Banevič B, Stasevych M, Mickevičius V.   +5 more
europepmc   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Thiazolidine-Grafted Zeolite Imidazolate Frameworks: A Cysteine-Derived Route to Improved Metal Loading and Tune the CO₂ Hydrogenation Efficiency. [PDF]

ChemSusChem
Mercé M, García-Verdugo E, Cirujano FG, Martín N.   +3 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

An Efficient H‑Reduction Protocol for the Synthesis of Novel (Benz)imidazole-allyl Alcohol and Imidazole-1,3-diol Derivatives. [PDF]

ACS Omega
Mhasni O, Châabani N, Triaa N, Bouajila J, Rezgui F.   +4 more
europepmc   +1 more source