Results 201 to 210 of about 288,362 (336)

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Theoretical Insights into the Impact of Pyrrole and Imidazole Substituents on the BODIPY Chromophore. [PDF]

Molecules
Piękoś P, Lipkowski P, Dehaen W, Wieczorek R, Filarowski A.   +4 more
europepmc   +1 more source

Synthesis of Imidazoles by Catalytic Dehydrogenation of Imidazolines

, 1968
N. SAWA
openalex   +2 more sources

Protonation of the Radical-anions of Nitro-imidazole Radiosensitizers and the Formation of Radical-adducts [PDF]

, 1975
Peter Wardman
openalex   +1 more source

Mutation of Surface Histidines in \u3ci\u3eHaemophilus influenzae\u3c/i\u3e Carbonic Anhydrase to Enable Purification by Metal Affinity Chromatography [PDF]

, 2016
Cornely, Kathleen, Scola, Shelby E.
core   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Rab11 Binding Promotes the p14 FAST Protein-Induced Syncytium Formation. [PDF]

ACS Omega
Lin S, Qi Z, Yu Q, Ma R, Zhang K, Jiang W, Mai Y, Fu QB.   +7 more
europepmc   +1 more source

Studies on Imidazole Derivatives as Chelating Agents. III. Syntheses of Schiff Bases and 4 (5)-Aminomethyl Derivatives and Their Reactions with Metal Ions.

, 1967
Osamu Yamauchi, Hisashi Tanaka, Toyozo Uno   +2 more
openalex   +2 more sources

Pyrrole Hydrogen Ionization of Imidazole Derivatives in Metal Ion Complexes and Carbonic Anhydrase [PDF]

, 1974
R. Bruce Martin
openalex   +1 more source

Assembling Hexahedral Supramolecular Nano‐Aggregates on Rice Wax Layer Matrices to Promote the Leaf Deposition and Bioavailability of Bactericides for Plant Protections

Advanced Science, EarlyView.
To address the problem of off‐target movement and low bioavailability of pesticides, two anisotropic supramolecular building units (BiTA18@β‐CD and BiTA18@γ‐CD) have been invented that can self‐assemble into nano‐sized hexagonal cuboids on the rice microcrystalline matrix. This manipulation realizes the enhanced utilization of bactericides for rice and
Run Yang, Jinghan Yang, Min Liu, Juan Liu, Peiyi Wang   +4 more
wiley   +1 more source