Results 261 to 270 of about 339,340 (383)

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

Advanced Science, EarlyView.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu   +7 more
wiley   +1 more source

Gating Mechanism for Biased Agonism at Angiotensin II Type 1 Receptors. [PDF]

Molecules
Moore GJ, Ridgway H, Gadanec LK, Apostolopoulos V, Zulli A, Matsoukas JM.   +5 more
europepmc   +1 more source

Solvolysis of p-Nitrophenyl Acetate Catalyzed by Imidazole Hydrogen-Bonded to Solvent

, 1970
Fujio Takahashi
openalex   +2 more sources

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

Advanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, Zhichao Wu, Jun Zou, Liangbiao Chen, Jialong Yang, Peng Hu   +14 more
wiley   +1 more source

Antiproliferative Water-Soluble Mono- and Binuclear Ruthenium Complexes with Pyridone-Imidazole Ligands. [PDF]

Int J Mol Sci
Shutkov IA, Melnichuk NA, Ovakimyan SA, Mazur DM, Borisova NE, Kuznetsov ML, Godovikov IA, Lyssenko KA, Yakovlev DS, Spasov AA, Milaeva ER, Nazarov AA.   +11 more
europepmc   +1 more source

Ternary Molecular Co‐Assembling Heterogeneous Membranes for High‐Efficiency and Anti‐Biofouling Osmotic Energy Conversion

Advanced Science, EarlyView.
A new strategy based on ternary molecular co‐assembly for the facile construction of nanofluidic membranes is presented. The membrane exhibits asymmetric nanochannels that facilitate anion‐selective transport, achieving an osmotic energy harvesting performance of 16.6 W·m−2 and a superior anti‐biofouling activity in natural waters.
Minmin Li, Yuting Xiong, Fenglin Zhang, Haijie Wei, Yuchen Cao, Guangyan Qing   +5 more
wiley   +1 more source

CrypToth: Cryptic Pocket Detection through Mixed-Solvent Molecular Dynamics Simulations-Based Topological Data Analysis. [PDF]

J Chem Inf Model
Koseki J, Motono C, Yanagisawa K, Kudo G, Yoshino R, Hirokawa T, Imai K.   +6 more
europepmc   +1 more source

High‐Throughput MicroED for Probing Ion Channel Dynamics

Advanced Science, EarlyView.
High‐throughput MicroED offers a new approach for visualizing ion channel dynamics. This approach reveals NaK’s sodium binding modes and NaK2CNG’s potassium‐induced selectivity filter dilation and gating. By capturing these distinct structures, this work challenges traditional models of ion channel permeation and selectivity. Abstract Ion channels play
Marc J Gallenito, Max TB Clabbers, Jieye Lin, Johan Hattne, Tamir Gonen   +4 more
wiley   +1 more source

Synthesis and Characterization of PEG-<i>b</i>-1-Vinyl Imidazole Diblock Copolymers and Their Preliminary Evaluation for Biomedical Applications. [PDF]

Polymers (Basel)
Kitiri EN, Shegani A, Kopanos I, Pirmettis N, Triantis C, Rikkou-Kalourkoti M.   +5 more
europepmc   +1 more source

Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light‐Driven Nanozyme Sensor Array and Machine Learning

Advanced Science, EarlyView.
A novel photoresponsive nanozyme sensor array, combining metal‐organic frameworks (MOFs) with advanced machine learning algorithms, provides a breakthrough in rapid neurotransmitter detection and disease diagnostics. This sensor array is capable of accurately identifying neurotransmitter profiles associated with neurological disorders, offering ...
Kun Yu, Siyuan Lu, Kaiwen Qiu, Yuanzun Zhang, Aobing Sun, Shiqi Gong, Kai Wang, Xuzhu Gao, Xiangyu Xu, Hao Wang   +9 more
wiley   +1 more source