Results 81 to 90 of about 279,326 (208)

Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. [PDF]

, 2014
Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP.
Amitai, Gabriel, Fokin, Valery V, Radić, Zoran, Sharpless, K Barry, Sit, Rakesh K, Taylor, Palmer   +5 more
core  

Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures

Antibiotics, 2019
Clavulanic acid (CA) is a β-lactam antibiotic inhibitor of β-lactamase enzymes, which confers resistance to bacteria against several antibiotics.
David Gómez-Ríos, Howard Ramírez-Malule, Peter Neubauer, Stefan Junne, Rigoberto Ríos-Estepa   +4 more
doaj   +1 more source

Diethyl 4-(4-chloro-2-propyl-1H-imidazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate monohydrate

IUCrData, 2018
In the title hydrate, C19H26ClN3O4·H2O, the imidazole ring is nearly perpendicular [dihedral angle = 89.5 (1)°] to the dihydropyridine moiety. The propyl and one of the ethyl groups are disordered over two resolved sets of sites [occupancy factors 0.524 (
Kedila Rasheeda, Seranthimata Samshuddin, Phadke N. Swathi, Vijaya D. P. Alva, Joel T. Mague, Youssef Ramli   +5 more
doaj   +1 more source

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

Potent Antimicrobial Azoles: Synthesis, In Vitro and In Silico Study

Antibiotics
Background/Objectives: The increase in fungal infections, both systemic and invasive, is a major source of morbidity and mortality, particularly among immunocompromised people such as cancer patients and organ transplant recipients.
Zeynep Özdemir, Yaren Nur Zenni, Arzu Karakurt, Suat Sari, Selma Saraç, Mevlüt Akdağ, İrem Bozbey Merde, Didem Kart, Roberto Venanzoni, Giancarlo Angeles Flores, Paola Angelini, Muzammil Kabier, Bijo Mathew, Simone Carradori   +13 more
doaj   +1 more source

Semiconducting polymers for gas detection [PDF]

Conjugated polyenes, and polyesters containing phthalocyanine in their backbone, were synthesized. These polymers were characterized by chemical analysis, thermogravimetric analysis, spectral analysis, and X-ray diffraction studies for crystallinity, as ...
Byrd, N. R., Sheratte, M. B.
core   +1 more source

Film Properties of Heparin Cross-Linked with Epichlorohydrin in Absence or Presence of Imidazole

Polysaccharides
We cross-linked unfractionated heparin (H) using epichlorohydrin (E), in the absence or presence of imidazole (I), using various ratios of H, E, and I substances.
Ivan Šimkovic, Filip Gucmann, Michal Hricovíni, Raniero Mendichi, Edmund Dobročka, Alberto Giacometti Schieroni, Daniele Piovani, Stefania Zappia, Miloš Hricovíni   +8 more
doaj   +1 more source

A structural interpretation of the acidity of groups associated with the hemes of hemoglobin and hemoglobin derivatives [PDF]

, 1940
Since the discovery by Bohr and coworkers in 1904 of the effect of acidity on the oxygen equilibrium of hemoglobin, there have been a large number of investigations directed towards clarification of the physicochemical relationships of acid groups with ...
Coryell, Charles D., Pauling, Linus
core  

High-valent copper in biomimetic and biological oxidations [PDF]

, 2016
A long-standing debate in the Cu-O2 field has revolved around the relevance of the Cu(III) oxidation state in biological redox processes. The proposal of Cu(III) in biology is generally challenged as no spectroscopic or structural evidence exists ...
Gary, J. Brannon
core   +1 more source

Expression and purification of an NSD3-GB1 fusion protein as a way to study the structure of complex formation with Brd4 ET. [PDF]

, 2020
The BRD4 protein belongs to the bromodomain and extraterminal domain (BET) family of eukaryotic transcription factors, and is linked to several types of cancer, inflammation, and obesity.
Tuokkola, Jennifer
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