Results 141 to 150 of about 16,360 (266)

An Immediate‐Response Detection System for γ‐Hydroxybutyrate to Enhance Personal Safety in Social Environments

Advanced Science, EarlyView.
A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An, Jisung Kwak, Kyung Ho Kim, Chaeeun Kim, Sung Eun Seo, Nathaniel S. Hwang, Yong‐Sang Ryu, Hyun Seok Song, Oh Seok Kwon   +8 more
wiley   +1 more source

The Effect of <i>N</i>-Alkyl Azole Difluorination on Molecular Properties Relevant for Compound Optimization: A Comparative Study. [PDF]

ACS Med Chem Lett
Herrick RM, Green SA, Rich S, Grandner JM, Huard K, Altman RA.   +5 more
europepmc   +1 more source

Multiscale Modelling of the Electrocatalysis of Microenzymes: Insights Into the Performance of Microperoxidase at an Aqueous/Graphene Interface and Their Exploitation to Improve Performance

Advanced Science, EarlyView.
A novel multiscale MD/DFT framework to elucidate microenzyme adsorption and electron transfer is reported. This method reveals distinct configurations for microperoxidase‐11 on graphene and those best suited for electron transfer. Rate constants align with the limited experimental data, establishing this framework as a tool for optimizing microenzyme ...
Milan Mijajlovic, Cheng Hu, Yuhui Sun, Matthew J. Penna, Meisam V. Kiamahalleh, Wenrong Yang, Mark J. Biggs   +6 more
wiley   +1 more source

Electrochemical cyclization of alkynes to construct five-membered nitrogen-heterocyclic rings. [PDF]

Beilstein J Org Chem
Peng L, Wang T, Yuan Z, Li B, Tang Z, Liu X, Li H, Jiang G, Zeng C, Wong HNC, Peng XS.   +10 more
europepmc   +1 more source

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

Green synthesis of imidazole derivatives in a ternary deep eutectic solvent system. [PDF]

Sci Rep
Mohammad F, Azizi N, Mirjafari Z, Mokhtari J.   +3 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

A Case of Immunotherapy Response to BRAF^V600E-Mutant Lung Adenocarcinoma With Initial Resistance to Dabrafenib and Trametinib Combination Therapy. [PDF]

Cancer Rep (Hoboken)
Okayama Y, Tokito T, Shiraishi S, Takaki R, Tsuneyoshi S, Yamada H, Nishiyama M, Sueyasu Y, Hoshino T.   +8 more
europepmc   +1 more source

Vanadium Cation Exchange‐Driven Reconstruction of MOF‐Derived Cobalt Hydroxide Electrodes for Electrocatalysis and Energy Storage

Advanced Science, EarlyView.
A room‐temperature vanadium cation exchange strategy is developed to achieve simultaneous structural reconstruction and electronic/defect modulation of ZIF‐67 on nickel foam. The resulting mesoporous V20–Co(OH)2 electrode exhibits superior OER activity with low overpotentials and enhanced lattice oxygen participation.
Yongbeen Kim, Seungwoo Han, Wonyoung Lee
wiley   +1 more source

Synthesis of 1-Fluoroalkyl-5-Substituted-1,2,3-Triazoles from Carbonyl-Stabilized Phosphonium Ylides. [PDF]

J Org Chem
Tichý D, Černý T, Filgas J, Voltrová S, Klepetářová B, Beier P.   +5 more
europepmc   +1 more source