Results 121 to 130 of about 22,275 (301)
Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
Imidazoles from the reaction of periodate-oxidized polysaccharides with ammonia
, 1970 Periodate-oxidized amylose reacts with aqueous ammonia to give imidazole and 4(5)-(2-hydroxyethyl)imidazole while periodate-oxidized dextran gives imidazole and 4(5)-methylimidazole.
EL Richards
core +1 more source
Advanced Science, EarlyView.Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park +13 more
wiley +1 more source
, 2017 Les bicycles imidazo-imidazoles constituent une classe de composés hétérocycliques intéressants tant sur le plan chimique que pharmaceutique. Ils jouent un rôle très important dans la synthèse et la fonctionnalisation des composés à visé thérapeutique ...
Loubidi, Mohammed
core
Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer +17 more
wiley +1 more source
Solvent-Free Synthesis of Cyanoformamides from Carbamoyl Imidazoles
, 2017 A straightforward and solvent-free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed.
Campbell, Sarah G. +7 more
core +1 more source
α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths
Advanced Science, EarlyView.At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel +10 more
wiley +1 more source
Convenient sulfonylation of imidazoles and triazoles using NFSI
, 2018 A protocol for the synthesis of N-sulfonyl imidazoles and triazoles has been achieved using N-Fluorobenzenesulfonimide as a sulfonyl source. This reaction proceeded well in the absence of strong bases and catalysts, providing a convenient alternative ...
Hu Cai (2398693) +4 more
core +1 more source
One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections
Advanced Science, EarlyView.Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong +11 more
wiley +1 more source