Results 341 to 350 of about 106,252 (402)

Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles.

Angewandte Chemie, 2017
Described herein is the preparation of oxalyl boronate building blocks and their application for the construction of heterocycles. The oxalyl unit, readily accessible through commercially available starting materials, enables a modular approach for the ...
C. Frank Lee, Aleksandra Holownia, James M. Bennett, Jonathan M Elkins, Jeffrey D. St. Denis, S. Adachi, A. Yudin   +6 more
semanticscholar   +1 more source

Stimulation of glycolysis by imidazole

Life Sciences, 1973
Abstract Imidazole stimulated glycolysis by rat diaphragm homogenates; this effect increased as the concentration of imidazole was raised. The simultaneous changes in concentration of some of the glycolytic intermediates suggested an action of imidazole at a step between triose phosphate and pyruvate.
Norman Kalant, Rehana Parvin
openaire   +3 more sources

Dual Roles of Methyl Ketones in Radziszewski-Type Reaction: Formal [2 + 1 + 1 + 1] Synthesis of 1,2,5-Trisubstituted Imidazoles.

Organic Letters, 2016
A highly efficient molecular iodine mediated Radziszewski-type reaction of methyl ketones, anilines, and tosylmethyl isocyanide has been developed. This protocol represents an elegant molecular fragment assembly of imidazoles via a formal [2 + 1 + 1 + 1]
Jingjing Zhang, Qinghe Gao, Xia Wu, Xiao Geng, Yan‐Dong Wu, A. Wu   +5 more
semanticscholar   +1 more source

Sterically Encumbered Tetraarylimidazolium Carbene Pd-PEPPSI Complexes: Highly Efficient Direct Arylation of Imidazoles with Aryl Bromides under Aerobic Conditions

, 2016
A series of sterically encumbered tetraarylimidazolium carbene Pd-PEPPSI complexes were conveniently prepared and fully characterized. These sterically encumbered Pd-PEPPSI complexes act as active precatalysts for the direct arylation of imidazoles with ...
Xu-Xian He, Yinwu Li, Bei-bei Ma, Zhuofeng Ke, Feng-Shou Liu   +4 more
semanticscholar   +1 more source

Imidazoles

2008
Imidazoles, benzimidazoles, imidazolines, imidazolidines, and related carbenes are classes of heterocyclic compounds possessing unique chemical and physical properties. Tremendous advances in imidazole chemistry have been made in the decade since 1995, and are manifested in the large body of the literature related to imidazole and its analogs.
Longbin Liu, Qi Huang, Ning Xi
openaire   +2 more sources

Prebiotic synthesis of imidazole-4-acetaldehyde, imidazole-4-glycol and imidazole-4-ethanol

Origins of life and evolution of the biosphere, 1986
A wide var iety of chemical processes have been used for the synthesis of amino acids from prebiot ic molecular precursors under plausible pr imi t ive Earth conditions (M i l l e r , 1982). The prebiot ic formation of a l l protein-type amino acids has been demonstrated except for three amino acids: h is t id ine , lys ine, and arginine (Weber and Mi ...
Stanley L. Miller, C. Shen, L. Yang, J. Oró   +3 more
openaire   +2 more sources

One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles via [2 + 2 + 1] Cycloannulation of 1,3-Bishet(aryl)-monothio-1,3-diketones, α-Substituted Methylamines and Sodium Nitrite through α-Nitrosation of Enaminones.

Journal of Organic Chemistry, 2016
An efficient one-pot synthesis of a series of diversely functionalized trisubstituted 4(5)het(aroyl)-2,5(4)-het(aryl)/alkylimidazoles from readily available 1,3-bishet(aryl)monothio-1,3-diketones has been reported.
S. Yugandar, S. Konda, G. Parameshwarappa, H. Ila   +3 more
semanticscholar   +1 more source

A Domino Azidation/C-H Amination Approach toward Trifluoromethyl Substituted Imidazoles.

Journal of Organic Chemistry, 2017
N-Alkyl enamines can be transformed into 2,4,5-trisubsituted imidazoles by reacting with (diacetoxyiodo)benzene and TMSN3 under the catalysis of a copper salt such as Cu(OAc)2. Tetrabutyl ammonium iodide was also capable of promoting the reaction.
Haichao Ma, Xiaoyan Zhang, Liangliang Chen, Wei Yu   +3 more
semanticscholar   +1 more source

The 4H-Imidazoles

1984
Publisher Summary This chapter discusses the 4H-imidazoles that have a tetrahedral carbon atom in the ring and thus are nonaromatic. The synthesis of 4H-imidazoles can be done from transformation of imidazolone derivatives, ketones and amidines, imines and amidines, reaction between 1H-imidazoles and electrophiles, azirines, and methods for N-oxides.
Michael P. Sammes, Alan R. Katritzky
openaire   +2 more sources

Imidazole: Fungitoxic Derivatives

Science, 1967
Study of several new types of fungitoxic derivatives of imidazole reveals that imidazoles substituted on the imine nitrogen atom are likely to be active if the substituent is electron-attracting, and if the atom connecting it to the imidazolyl moiety has tetrahedral geometry.
James N. Seiber, Paul B. Budde, Dorsey R Mussell, Henry Tolkmith   +3 more
openaire   +3 more sources