Results 111 to 120 of about 55,611 (282)

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

Angewandte Chemie, EarlyView.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang, Lei Wang, Marco Hadisurya, Siavash Shahbazi Nia, W. Andy Tao, Emily C. Dykhuizen, Casey J. Krusemark   +6 more
wiley   +2 more sources

2-{(E)-{{(R)-1-[(1R,5S,6R)-3,3-Dimethyl-2,4,7-trioxabicyclo[3.3.0]octan-6-yl]ethyl}imino}methyl}-6-{[(diphenylphosphino)oxy] phenyl}palladium(II) chloride

Molbank
An unsymmetrical PCN palladium pincer complex 2-{(E)-{{(R)-1-[(1R,5S,6R)-3,3-dimethyl-2,4,7-trioxabicyclo[3.3.0]octan-6-yl]ethyl}imino}methyl}-6-{[(diphenylphosphino)oxy] phenyl}palladium(II) chloride based on an iminophosphinite ligand bearing two fused
Stéphane Guillarme, Christine Saluzzo
doaj   +1 more source

Poly(ethylene imine) Impurities Induce n‐doping Reaction in Organic (Semi)Conductors

, 2014
Simone Fabiano, Slawomir Braun, Xianjie Liu, Eric Weverberghs, Pascal Gerbaux, Mats Fahlman, Magnus Berggren, Xavier Crispin   +7 more
openalex   +2 more sources

Harnessing Transformation of Metal‐Ligand Coordination in Dinuclear Ni(II)‐Schiff Base Coordination Polymer for Promoting Electrochemical Oxygen Evolution

Advanced Science, EarlyView.
Ni–Schiff base coordination polymer [Ni2(tmd)2]n was synthesized and applied to enhance alkaline OER by virtue of its transformation between 5‐ and 6‐coordinate Ni sites along with the spin state exchange. ABSTRACT One of the major challenges in overall water splitting is improving the sluggish kinetics of the anodic oxygen evolution reaction (OER ...
Ruei‐Hung Juang, Han‐Jung Li, Yu‐Chung Chang, Chieh‐Wei Chang, Ricky Yu‐Syun Fan, Kien Voon Kong, Jeng‐Lung Chen, Chia‐Shuo Hsu, Po‐Heng Lin, Chun‐Hong Kuo   +9 more
wiley   +1 more source

Covalent Organic Framework–Carbon Nanotube Core–Shell Nanohybrids for Enhanced Catalytic Site Utilization of Molecular Catalysts in CO2 Electroreduction

Angewandte Chemie, EarlyView.
Covalent organic framework–carbon nanotube (COF–CNT) core–shell nanohybrids are developed as an efficient platform to enhance the site utilization of molecular catalysts for electrochemical CO2 reduction. The well‐defined nanostructure promotes catalytic site accessibility, achieving CO turnover frequencies among the highest reported to date.
Liang Yao, Andrés Rodríguez‐Camargo, Roman Guntermann, Fabian Heck, Samuel Van Gele, Hugo Vignolo‐González, Viola Duppel, Thomas Bein, Bettina V. Lotsch   +8 more
wiley   +2 more sources

Ruthenium Complex Catalyzed Direct ortho Arylation and Alkenylation of Aromatic Imines with Organic Halides.

, 2002
Shuichi Ôi, Yukako Ogino, Susumu Fukita, Yoshio Inoue   +3 more
openalex   +2 more sources

A Metal‐Free Molecular Ferroelectric With Large Piezoelectricity and Its Porous Composite for Superior Output Power Density

Advanced Science, EarlyView.
Metal‐free molecular crystal [(CH3C6H10NH3)(18‐crown‐6)][ClO4] functions as a high‐performance molecular ferroelectric. Through strategic methylation of the cyclohexylamine unit, the compound achieves large spontaneous polarization and outstanding piezoelectric coefficients.
Nan Chen, Wenjuan Wei, Le Ye, Lingyu Wan, Yen Wei   +4 more
wiley   +1 more source

Aminal‐linked Covalent Organic Frameworks for Light Energy Upconversion

Angewandte Chemie, EarlyView.
Aminal‐linked covalent organic frameworks incorporating anthracene units are introduced as solid‐state platforms for triplet–triplet annihilation upconversion. The crystalline materials retain chromophore electronic properties and exhibit fluorescence quantum yields of up to 40%.
Mateusz Brzeziński, Agata Tyszka‐Gumkowska, Aleksander Gorski, Marek J. Potrzebowski, Tomasz Polczyk, Wojciech Wegner, Sylwester Gawinkowski, Jakub Ostapko   +7 more
wiley   +2 more sources

Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines

Advanced Science, EarlyView.
Difluoromethyl (CF2H) group, the bioisostere of hydroxyl thiol methyl or amide is privileged in medicinal chemistry due to hydrogen‐binding ability and lipophilic, metabolically stable, and chemical inert nature. However, enatioseleceive CF2H introduction remains challenging.
Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang   +9 more
wiley   +1 more source