Results 91 to 100 of about 65,673 (219)

A Disproportionality Analysis of β‐lactam Antibiotic Related Blood and Lymphatic System Disorders Based on the FDA Adverse Event Reporting System Database

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims β‐lactam antibiotics stand as the most profoundly impactful classes of antibacterial agents worldwide. Their widespread application has raised safety concerns over adverse events (AEs), such as blood and lymphatic system disorders (BLSDs).
Jing Liu, Min Zhang, Zongwei Tang, Xiaoxiao Wang, Li Mu, Wanyi Chen, Haichi Song   +6 more
wiley   +1 more source

Evaluation the antibacterial activity of nanoantibiotics imipenem and ciprofloxacin loaded in human serum albumin against some antibiotic-resistant pathogenic bacteria

Journal of Experimental Nanoscience, 2020
Introduction Microbial resistance is increasing worldwide. Investigations are underway to use nanoparticles as antimicrobial agents to reduce microbial resistance.
Shima Shafiei, Mehdi Hassanshahian, Shahryar Shakeri, Homa Hamayeli   +3 more
doaj   +1 more source

Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases

iMetaOmics, Volume 3, Issue 3, September 2026.
An integrative metagenomic framework combining sequence, structural, and functional inference reveals a phylogenetically diverse and structurally conserved repertoire of putative beta‐lactamases across Antarctic soil microbiomes, with predominance of class A and subclass B3 enzymes and limited but detectable associations with mobile genetic elements ...
José Coche‐Miranda, Patricio Arros, Nicolás Canales, Camilo Berríos‐Pastén, Gastón Azziz, Rosalba Lagos, Julieta Orlando, Francisco P. Chávez, Andrés E. Marcoleta   +8 more
wiley   +1 more source

AmpC induction by imipenem in Pseudomonas aeruginosa occurs in the absence of OprD and impacts imipenem/relebactam susceptibility

In the United States, carbapenem resistance in Pseudomonas aeruginosa is linked to the regulation of chromosomal resistance determinants, AmpC and OprD.
Nancy D. Hanson, Shawn Freed, Jr
core   +1 more source

Comparative study of imipenem in severe infections. [PDF]

, 1983
Forty patients with severe bacterial infections due to micro-organisms known or presumed to be sensitive to both study antibiotics, were randomized to receive either imipenem with cilastatin, 500 mg/500 mg iv tid (20 patients), or cefotaxime, 2 g iv tid (
Baumgartner, J.D., Glauser, M.P.
core   +1 more source

Population pharmacokinetics of imipenem in different populations for individualized dosing: a systematic review

Frontiers in Pharmacology
BackgroundImipenem is a broad-spectrum carbapenem antibiotic for severe infections with significant pharmacokinetic (PK) variability. This review systematically synthesized published population pharmacokinetic (popPK) studies to identify key covariates ...
Ping Zhang, Yuhua Zhao, Jianping Zhu, Yi Yang, Gang Liang, Xia Wang, Zhenwei Yu, Zhenwei Yu   +7 more
doaj   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, Volume 57, Issue 9, Page 1554-1564, September 2026.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Efficacies of omadacycline + amikacin + imipenem and an all-oral regimen omadacycline + clofazimine + linezolid in a mouse model of M. abscessus lung disease

mSphere
Treatment outcomes for Mycobacteroides abscessus (Mab, also known as Mycobacterium abscessus) disease are still unsatisfactory, mainly due to issues with drug toxicity, tolerability, and efficacy.
Elisa H. Ignatius, Binayak Rimal, Chandra M. Panthi, Daniel C. Belz, Christopher K. Lippincott, Daniel H. Deck, Alisa W. Serio, Gyanu Lamichhane   +7 more
doaj   +1 more source

Focused Update to International Consensus Recommendations for the Use of Prolonged‐Infusion Beta‐Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 9, September 2026.
ABSTRACT In 2023, international consensus recommendations suggested the use of prolonged‐infusion beta‐lactam antibiotics over short‐infusion dosing in severely ill adult patients to improve mortality or clinical cure, although the certainty of evidence was very low. With the availability of several new randomized controlled trials (RCTs), this focused
Lisa T. Hong, Alireza FakhriRavari, Marta Ulldemolins, Jason A. Roberts, Robert A. Bonomo, Marc H. Scheetz, on behalf of the Prolonged‐Infusion Beta‐Lactam Consensus Panel, Jacinda C. Abdul‐Mutakabbir, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Kevin J. Downes, Alireza FakhriRavari, Mark Gilchrist, Lisa T. Hong, Jason A. Roberts, Marc H. Scheetz, Thomas Tängdén, Marta Ulldemolins, David C. Young   +19 more
wiley   +1 more source

Prevalence and Genomic Characterization of mcr‐Positive Enterobacteriaceae in Retail Meat in Thailand Following the Colistin Ban

Microbiology and Immunology, Volume 70, Issue 9, Page 402-415, September 2026.
ABSTRACT This study aimed to investigate the prevalence and characteristics of mcr‐positive Enterobacteriaceae in retail meat in Thailand following the national ban on prophylactic colistin use in food producing animals. A total of 152 meat samples (103 chicken and 49 pork) were collected from supermarkets and open markets between July and September ...
Ahmed Abououf, Sharda Prasad Awasthi, Asmaa M. Elbastawesy, Noritoshi Hatanaka, Atsushi Hinenoya, Srinuan Somroop, Yukihiro Kaneko, Shinji Yamasaki   +7 more
wiley   +1 more source