Results 21 to 30 of about 89,589 (279)

Effect of Imipenem and Amikacin Combination against Multi-Drug Resistant Pseudomonas aeruginosa

Antibiotics, 2021
Pseudomonas aeruginosa is an opportunistic nosocomial pathogen associated with high morbidity and mortality rates. Combination of antibiotics has been found to combat multi-drug resistant or extensively drug resistance P. aeruginosa.
Sara Mahmoud Farhan, Mohamed Raafat, Mohammed A. S. Abourehab, Rehab Mahmoud Abd El-Baky, Salah Abdalla, Ahmed Osama EL-Gendy, Ahmed Farag Azmy   +6 more
doaj   +1 more source

Identification, Genotyping and Antimicrobial Susceptibility Testing of Brucella spp. Isolated from Livestock in Egypt [PDF]

, 2019
Brucellosis is a highly contagious zoonosis worldwide with economic and public health impacts. The aim of the present study was to identify Brucella (B.) spp. isolated from animal populations located in different districts of Egypt and to determine their
El-Adawy, Hosny, Elschner, Mandy C., Khan, Aman Ullah, Melzer, Falk, Moawad, Amira A., Neubauer, Heinrich, Ramadan, Eman Shawkat, Roesler, Uwe, Sayour, Ashraf E., Shell, Waleed S.   +9 more
core   +1 more source

Predicting the Effects of Carbapenem/Carbapenemase Inhibitor Combinations against KPC-Producing Klebsiella pneumoniae in Time-Kill Experiments: Alternative versus Traditional Approaches to MIC Determination

Antibiotics, 2021
Traditionally, the antibacterial activity of β-lactam antibiotics in the presence of β-lactamase inhibitors is determined at the fixed inhibitor concentration.
Alla V. Filimonova, Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Anastasiya A. Kuznetsova, Stephen H. Zinner   +5 more
doaj   +1 more source

The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop [PDF]

, 2018
Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria.
Alzari, Pedro M., Bethel, Christopher R., Bonomo, Robert A., Giannini, Estefanía, Klinke, Sebastian, Llarrull, Leticia Irene, Mojica, María F., Otero, Lisandro Horacio, Palacios, Antonela Rocio, Taracila, Magdalena A., Vila, Alejandro Jose   +10 more
core   +1 more source

Molecular detection of metallo-β-lactamase gene blaVIM-1 in imipenem-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients in the hospitals of Isfahan

Advanced Biomedical Research, 2015
Background: Pseudomonas aeruginosa is an opportunistic human pathogen that causes serious problems, especially in people, who have immunodeficiency. In recent times, metallo-β-lactamase (MBLs) resistance in this bacterium has led to some difficulties in ...
Mansour Sedighi, Hamid Vaez, Mohsen Moghoofeie, Shima Hadifar, Golfam Oryan, Jamshid Faghri   +5 more
doaj   +1 more source

Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype [PDF]

, 2017
Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs).
Bordignon, Valentina, Cavallo, Ilaria, Cilli, Laura, De Santis, Alessandra, Di Domenico, Enea Gino, Di Salvo, Fabiola, Ensoli, Fabrizio, Farulla, Ilaria, Gallo, Maria Teresa, La Parola, Ilaria Lesnoni, Pimpinelli, Fulvia, Pontone, Martina, Prignano, Grazia, Sperduti, Isabella, Toma, Luigi, Vespaziani, Matteo   +15 more
core   +2 more sources

Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]

, 2018
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J., Guerra, B., Rodicio Rodicio, María del Rosario   +2 more
core   +3 more sources

First time identification of Pandoraea sputorum from a patient with cystic fibrosis in Argentina: a case report [PDF]

, 2017
Background: Pandoraea species are considered emerging pathogens in the context of cystic fibrosis (CF) and are difficult to identify by conventional biochemical methods. These multidrug resistant bacteria remain poorly understood particularly in terms of
Alvarez, Florencia, Barrias, Carolina, Bettiol, Marisa, Bosch, María Alejandra, Ferreras, Julian Alberto, Frada, Guillermo, Lagares, Antonio, Leguizamon, Lorena Beatriz, Martina, Pablo F., Martínez, Mónica Elisabeth, Prieto, Claudia Inés, Von Specht, Martha Helena   +11 more
core   +2 more sources

Direct Colorimetry of Imipenem Decomposition as a Novel Cost-Effective Method for Detecting Carbapenemase-Producing Enterobacteria

Microbiology Spectrum, 2022
In the absence of a molecule that would collectively inhibit both metallo-β-lactamases and serine-reactive carbapenemases, containment of their genes is the main weapon currently available for confronting carbapenem resistance in hospitals.
Stathis D. Kotsakis, Anastasia Lambropoulou, Georgios Miliotis, Eva Tzelepi, Vivi Miriagou, Leonidas S. Tzouvelekis   +5 more
doaj   +1 more source

Phenotypic profile and molecular mechanism of resistance in carbapenemase-producing Enterobacterales and <i>Pseudomonas aeruginosa</i> isolates from Brazilian hospitals: implications for the introduction of imipenem-relebactam. [PDF]

Front Microbiol
Kurtz P, Del Peloso PF, Pribul BR, Albuquerque AM, Antunes BBP, Ramos GV, Bozza FA.   +6 more
europepmc   +3 more sources