Results 31 to 40 of about 65,673 (219)

Drug Utilization Evaluation of Imipenem and Assessing the Role of Pharmacist Interventions

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: This study aimed at evaluating utilization of imipenem and assessing the role of pharmacist in rational use of antibiotics. Materials and methods: A retrospective/prospective observational study was conducted in Ramsar Imam Sajjad
Neda Farzadi, Ebrahim Salehifar, Lotfollah Davoodi, Hamideh Abbaspour Kasgari   +3 more
doaj  

Imipenem heteroresistance but not tolerance in Haemophilus influenzae during chronic lung infection associated with chronic obstructive pulmonary disease

Frontiers in Microbiology, 2023
Antibiotic resistance is a major Public Health challenge worldwide. Mechanisms other than resistance are described as contributors to therapeutic failure.
Celia Gil-Campillo, Celia Gil-Campillo, Celia Gil-Campillo, Aida González-Díaz, Aida González-Díaz, Beatriz Rapún-Araiz, Beatriz Rapún-Araiz, Oihane Iriarte-Elizaintzin, Iris Elizalde-Gutiérrez, Ariadna Fernández-Calvet, María Lázaro-Díez, Sara Martí, Sara Martí, Junkal Garmendia, Junkal Garmendia, Junkal Garmendia   +15 more
doaj   +1 more source

Mortality rate in patients with nosocomial Acinetobacter meningitis from a Brazilian hospital

Brazilian Journal of Infectious Diseases
BACKGROUND: The mortality rate due to Acinetobacter baumannii nosocomial meningitis (ANM) is high. OBJECTIVE: The aim of this study was to evaluate the factors that have influence over the outcomes in ANM patients. METHODS: A retrospective analysis of 22
Felipe Francisco Tuon, Sergio R Penteado-Filho, Diogo Amarante, Marcio A Andrade, Luis A Borba   +4 more
doaj   +1 more source

Effect of sub MIC for Imipenem, Amikacin and Cefixime on Growth and Swarming of Proteus mirabilis

, 2018
The purpose of the present study is to evaluate the effect sub minimum inhibitory concentration (MIC) of imipenem, amikacin and cefixime on growth and swarming of Proteus mirabilis.
Naeem Rahman aljeburi, Hayder Hamzah Ibrahim, Muna Sabbar Jebar, Hadeer Ali Kudder, Saher Saleh Mahdi, Mustafa Ali Gayeb, Marwa Majed Naseer   +6 more
core   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Antibiotic resistance and molecular typing of Pseudomonas aeruginosa: focus on imipenem

Brazilian Journal of Infectious Diseases
Susceptibility tests by disk diffusion and by E-test and molecular typing by macrorestriction analysis were performed to determine the relatedness of Pseudomonas aeruginosa isolates from three distinct hospitals. The resistance profile of 124 isolates to
Ana Lúcia Peixoto de Freitas, Afonso Luis Barth   +1 more
doaj   +1 more source

Emergence of Carbapenem Resistant Non-Fermenting Gram-Negative Bacilli Isolated in an Icu of a Tertiary Care Hospital [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: The emergence and spread of Multi-Drug Resistant (MDR) Non-Fermenting Gram-Negative Bacilli (NFGNB) in Intensive Care Units (ICU) and their genetic potential to transmit diverse antibiotic resistance regardless of their ability to ...
Sonika Agarwal, Barnali Kakati, Sushant Khanduri, Shalini Gupta   +3 more
doaj   +1 more source

Comparative Investigation into the Roles of Imipenem:Cyclodextrin Complexation and Antibiotic Combination in Combatting Antimicrobial Resistance in Gram-Negative Bacteria

Pharmaceuticals, 2023
Extensively drug-resistant (XDR), multidrug-resistant (MDR) and pandrug-resistant (PDR) Gram-negative microorganisms (GNBs) are considered a significant global threat. β-lactam and aminoglycoside combinations and imipenem:cyclodextrin inclusion complexes
Sara Mahmoud Farhan, Rehab Mahmoud Abd El-Baky, Hala Rady Ahmed, Zeinab Fathalla, Ali Alamri, Hamdy Abdelkader, Adel Al Fatease   +6 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source