Results 51 to 60 of about 84,414 (220)

Conformational Changes in the Metallo-β-lactamase ImiS During the Catalytic Reaction: An EPR Spectrokinetic Study of Co(II)-Spin Label Interactions [PDF]

, 2008
Metallo-β-lactamases are responsible for conferring antibiotic resistance on certain pathogenic bacteria. In consequence, the search for inhibitors that may be useful in combating antibiotic resistance has fueled much study of the active sites of these ...
Bennett, Brian, Crowder, Michael W., Hu, Zhenxin, Sharma, Narayan   +3 more
core   +2 more sources

Decision fatigue in hospital medicine: A retrospective exploratory evaluation

Journal of Hospital Medicine, EarlyView.
Abstract Background “Decision fatigue” (DF) is the deterioration in decision‐making ability stemming from repeated decision making. Objective Explore DF over the clinical workblock and across hospitalist and work characteristics. Methods Patients seen by hospitalists at two hospitals in January and February 2022 were retrospectively evaluated for ...
Rachel M. Kruer, LaKeisha Boyd, Lauren Czosnowski, Sarah Jones, Kelsey Perry, Thomas J. Streepey, Areeba Kara   +6 more
wiley   +1 more source

Surgical Management of Diabetic Foot Ulcers: A Tanzanian University Teaching Hospital Experience. [PDF]

, 2011
\ud \ud Diabetic foot ulcers (DFUs) pose a therapeutic challenge to surgeons, especially in developing countries where health care resources are limited and the vast majority of patients present to health facilities late with advanced foot ulcers.
Chalya, Phillipo L, Mabula, Joseph B, Dass, Ramesh M, Kabangila, Rodrick, Jaka, Hyasinta, McHembe, Mabula D, Kataraihya, Johannes B, Mbelenge, Nkinda, Gilyoma, Japhet M   +8 more
core   +1 more source

Green Synthesis of ZnO Nanoparticles From Spirulina platensis: Antimicrobial and Cytotoxic Evaluation With Molecular Docking Studies

ChemistryOpen, EarlyView.
Algal‐extract‐derived ZnO nanoparticles show shape anisotropy and are bio capped by phytochemicals. These green‐synthesized NPs strongly inhibit S. aureus and K. pneumoniae biofilms. Molecular docking suggests stable binding of surface biomolecules to microbial targets, highlighting synergistic antibacterial mechanisms.
Muhammad Rizwan, Izaz Khan, Syed Sikandar Shah, Amir hamza khan, Abdurahman Hajinur Hirad, Saira Naz, Arshad Farid, Taimoor Khan, Said Hassan   +8 more
wiley   +1 more source

Utility of the ceftazidime-imipenem antagonism test (CIAT) to detect and confirm the presence of inducible AmpC beta-lactamases among enterobacteriaceae

Brazilian Journal of Infectious Diseases
Detection of AmpC beta-lactamase production by enterobacteria has been problematic. Contrary to ESBLs, no specific guidelines are available for detection and confirmation of AmpC production by clinical relevant microorganisms.
Vlademir Vicente Cantarelli, Everton Inamine, Teresa Cristina Z. Brodt, Carina Secchi, Bianca C. Cavalcante, Fabiana de Souza Pereira   +5 more
doaj   +1 more source

Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review [PDF]

, 2010
Background Pneumonia, and particularly nosocomial (NP) and ventilator-associated pneumonias (VAP), results in high morbidity and costs. NPs in particular are likely to be caused by Pseudomonas aeruginosa (PA), ~20% of which in observational studies are ...
Marya D Zilberberg, Joyce Chen, Samir H Mody, Andrew M Ramsey, Andrew F Shorr   +4 more
core   +2 more sources

Multiplex visual nucleic acid detection via isothermal cascaded transcription of fluorescent RNA aptamers

VIEW, EarlyView.
(1) Existing multiplex nucleic acid detection struggles to combine high sensitivity, visual readout, and instrument‐free use, which is vital for rapid infection and antibiotic resistance diagnosis. (2) We developed MAGIC, integrating isothermal cascaded amplification and fluorescent RNA aptamer transcription, achieving 10 aM sensitivity, 100% accuracy ...
Yu Tang, Na Luo, Binbin Xie, Jie Luo, Yaling Yuan, Junjie Fan, Zhiyong Liu, Haiyan Gao, Ming Chen, Kai Chang   +9 more
wiley   +1 more source

Distributed lags time series analysis versus linear correlation analysis (Pearson's r) in identifying the relationship between antipseudomonal antibiotic consumption and the susceptibility of Pseudomonas aeruginosa isolates in a single Intensive Care Unit of a tertiary hospital [PDF]

, 2011
The relationship between antibiotic consumption and selection of resistant strains has been studied mainly by employing conventional statistical methods.
Bielen, Luka, Bošnjak, Zrinka, Budimir, Ana, Erdeljić, Viktorija, Francetić, Igor, Kalenić, Smilja, Likić, Robert, Makar-Aušperger, Ksenija   +7 more
core   +1 more source

Epicutaneous and Drug Provocation Testing in Severe Cutaneous Adverse Reactions: A 20‐Year Single‐Centre Experience

Contact Dermatitis, EarlyView.
This study provides reassuring evidence in favour of early skin testing in patients with SCARs, argues against the necessity of a 6‐month delay, and underscores the pivotal role of oral provocation tests in the safe reintroduction of essential therapies. ABSTRACT Background Identifying and discontinuing the offending drug(s) in severe cutaneous adverse
Zohra Chadli, Khadija Mansour, Ghada Jaouahdou, Manel Ben Belgacem, Yosra Soua, Nadia Ben Fredj, Jameleddine Zili, Haifa Ben Romdhane, Karim Aouam   +8 more
wiley   +1 more source

Ciprofloxacin and Imipenem Resistance in Bathing Waters—Preliminary Studies of Great Rudnickie Lake

Applied Sciences
The phenomenon of bacterial resistance to antibiotics, the emission and spread of these bacteria, and the genes that determine antibiotic resistance in the environment are now a major health security concern.
Natalia Jendrzejewska, Ewa Karwowska
doaj   +1 more source