Results 51 to 60 of about 89,589 (279)

Effect of sub MIC for Imipenem, Amikacin and Cefixime on Growth and Swarming of Proteus mirabilis

Journal of Pure and Applied Microbiology, 2018
The purpose of the present study is to evaluate the effect sub minimum inhibitory concentration (MIC) of imipenem, amikacin and cefixime on growth and swarming of Proteus mirabilis.
Hayder Hamzah Ibrahim, Naeem Rahman aljeburi, Muna Sabbar Jebar, Mustafa Ali Gayeb, Saher Saleh Mahdi, Hadeer Ali Kudder, Marwa Majed Naseer   +6 more
doaj   +1 more source

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Trapping and Characterization of a Reaction Intermediate in Carbapenem Hydrolysis by \u3cem\u3eB. cereus\u3c/em\u3e Metallo-β-lactamase [PDF]

, 2008
Metallo-β-lactamases hydrolyze most β-lactam antibiotics. The lack of a successful inhibitor for them is related to the previous failure to characterize a reaction intermediate with a clinically useful substrate.
Tioni, Mariana F., Llarrull, Leticia l., Poeylaut-Palena, Andrés A., Martí, Marcelo A., Saggu, Miguel, Periyannan, Gopal R., Mata, Ernesto G., Bennett, Brian, Murgida, Daniel H., Vila, Alejandro J.   +9 more
core   +1 more source

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]

, 2016
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
A, A, A, A, A, A, A, A, A, A, A, A, A, AA, AC, AH, AJ, AK, AK, AM, AW, B, B, B, B, BJ, C, C, C, C, CA, CA, CE, D, D, D, DG, DP, E, EA, EE, F, F, F, F, FA, FM, FM, G, G, G, G, G, G, G, GA, GP, H, H, H, H, HAS, HE, I, I, I, I, IJ, J, J, JA, JE, JF, JG, JJ, JJ, JL, JR, JR, JR, JV, K, K, K, K, KA, KC, KYY, L, LJ, M, M, M, M, M, M, M, M, M, M, M, M, M, MA, MA, MA, MA, MC, MG, MM, MN, MP, N, N, NT, O, OR, P, P, P, P, PF, PK, R, R, R, R, R, R, R, RB, RG, RM, RR, RR, RS, RV, S, S, S, S, S, S, S, S, S, Sartelli, SJ, SK, SK, SM, SR, SR, SY, T, T, TL, TM, V, V, VG, VN, W, W, W, WL, WR, Y, YF, YH, YR, YS, Z, ZJ   +173 more
core   +4 more sources

VIM-1 Metallo-β-lactamase in Acinetobacter baumannii

Emerging Infectious Diseases, 2006
In 2004 and 2005, 5 metallo-β-lactamase (MBL)-positive Acinetobacter baumannii isolates were found in 2 Greek hospitals. Isolates were unrelated and carried blaVIM-1 in a class 1 integron; blaOXA-51- and blaOXA-58-like carbapenemase genes were also ...
Athanassios Tsakris, Alexandros Ikonomidis, Spyros Pournaras, Leonidas S. Tzouvelekis, Danai Sofianou, Nicholas J. Legakis, Antonios N. Maniatis   +6 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Comparative transcriptomics of multidrug-resistant Acinetobacter baumannii in response to antibiotic treatments [PDF]

, 2018
Multidrug-resistant Acinetobacter baumannii, a major hospital-acquired pathogen, is a serious health threat and poses a great challenge to healthcare providers.
Chan, Ting-Fung, Fong-Chuen Loo, Jacky, Ip, Margaret, Lau, Terrence Chi-Kong, Lin, Xiao, Qin, Hao, Tsui, Stephen Kwok-Wing, Wai-Sing Lo, Norman, Yim, Aldrin Kay-Yuen   +8 more
core   +2 more sources

Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome

Equine Veterinary Journal, EarlyView.
Abstract Background Based on human studies, surgical antimicrobial (AMD) prophylaxis (SAP) beyond 24 h is unnecessary and potentially detrimental. Objective To compare clinical and microbiological outcomes in patients receiving 24‐ or 72‐h of SAP for colic surgery. Study Design Prospective randomised clinical trial.
Louise L. Southwood, Alicia Long, Jairo Perez, Scott Daniel, Kyle Bittinger, Maia Aitken, Laurel Redding   +6 more
wiley   +1 more source

Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown, Caron, Cars, Cars, Collignon, Dagan, DiNubile, Drlica, Essack, Fox, Geli, Goren, Gould, Guillemot, Harris, Hurdle, Huttner, Isha, Madurell, Masterton, Michalsen, Mitchison, Mitchison, Molstad, Sharma, Solapure, Talbot, Thomas   +27 more
core   +2 more sources

Ciprofloxacin and Imipenem Resistance in Bathing Waters—Preliminary Studies of Great Rudnickie Lake

Applied Sciences
The phenomenon of bacterial resistance to antibiotics, the emission and spread of these bacteria, and the genes that determine antibiotic resistance in the environment are now a major health security concern.
Natalia Jendrzejewska, Ewa Karwowska
doaj   +1 more source