Results 1 to 10 of about 49,920 (311)
Frontiers in Oncology, 2021 BackgroundAnti-depressants have been reported to own anti-tumor potential types of cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not been elucidated.
Yuan-hao Lee +2 more
exaly +4 more sources
New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells [PDF]
Experimental and Molecular Medicine, 2020 Colorectal cancer: Antitumor antidepressant The antidepressant drug imipramine can block the activity of a protein that contributes to the progression of certain aggressive tumors.
Begoña Alburquerque-gonzález +2 more
exaly +5 more sources
Journal of Cellular and Molecular Medicine, 2021 Patients with malignant glioma often suffered from depression, which leads to an increased risk of detrimental outcomes. Imipramine, an FDA‐approved tricyclic antidepressant, has been commonly used to relieve depressive symptoms in the clinic.
Xiuping Zhou, Rutong Yu
exaly +2 more sources
Chronic imipramine treatment-induced changes in acetylcholinesterase (EC 3.1.1.7) activity in discrete rat brain regions [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Cholinergic as well as monoaminergic neurotransmission seems to be involved in the etiology of affective disorders. Chronic treatment with imipramine, a classical antidepressant drug, induces adaptive changes in monoaminergic neurotransmission.
R. Camarini, M.A.C. Benedito
doaj +3 more sources
Journal of Cellular and Molecular Medicine, 2020 Glioblastomas are the most aggressive type of brain tumour, with poor prognosis even after standard treatment such as surgical resection, temozolomide and radiation therapy. The overexpression of the nuclear factor kappa‐light‐chain‐enhancer of activated
I-tsang Chiang, Fei-ting Hsu
exaly +2 more sources
BMJ, The, 2015 Objectives To reanalyse SmithKline Beecham’s Study 329 (published by Keller and colleagues in 2001), the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with ...
David Healy +2 more
exaly +2 more sources
Administration of Harmine and Imipramine Alters Creatine Kinase and Mitochondrial Respiratory Chain Activities in the Rat Brain [PDF]
Depression Research and Treatment, 2012 The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain.
Carvalho-Silva, Milena +12 more
core +4 more sources
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse [PDF]
Acta Neuropathologica Communications, 2023 In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced generation of the sphingolipid ceramide by acid sphingomyelinase (A-SMase) triggered proinflammatory ...
Simone M. Crivelli +8 more
doaj +3 more sources
Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes
Journal of Pharmacological Sciences, 2012 Depression is one of the most prevalent and livelihood-threatening forms of mental illnesses and the neural circuitry underlying depression remains incompletely understood.
Katsura Takano +4 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 Recent studies demonstrate the involvement of inflammatory processes in the development of depression and the anti-inflammatory effects of antidepressants.
Svetlana I Galkina +2 more
exaly +3 more sources