Results 1 to 10 of about 20,679 (206)

Antidepressant and Anxiolytic Effect of Tramadol as Compared to Imipramine, in Acute and Chronic Dosage in Rats

open access: yesJournal of Aziz Fatimah Medical and Dental College, 2022
Objective: To assess the anti-depressant and anxiolytic effect of tramadol as compared to imipramine (approved antidepressant) in acute and chronic doses in rats.
Fiza Soomro   +3 more
doaj   +1 more source

Further characterization of the effect of the prototypical antidepressant imipramine on the microstructure of licking for sucrose.

open access: yesPLoS ONE, 2021
We previously reported that treatment with the prototypical antidepressant imipramine induced a dose-dependent reduction of the ingestion of a 10% sucrose solution, due to reduction of the licking burst number, thus suggesting reduced motivation and/or ...
Paolo S D'Aquila, Adriana Galistu
doaj   +1 more source

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

open access: yesFrontiers in Oncology, 2021
BackgroundAnti-depressants have been reported to own anti-tumor potential types of cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not been elucidated.
Po-Fu Yueh   +9 more
doaj   +1 more source

Effects of imipramine on cancer patients over-expressing Fascin1; description of the HITCLIF clinical trial

open access: yesFrontiers in Oncology, 2023
BackgroundTumor invasion and metastasis are responsible for the majority of cancer-related deaths. The identification of molecules involved in these processes is crucial to design effective treatments that can halt the progression of cancer.
Antonio Asensi-Cantó   +8 more
doaj   +1 more source

Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats

open access: yesJournal of Circadian Rhythms, 2018
The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine
Hiroshi Kawai   +6 more
doaj   +1 more source

Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats

open access: yesJournal of Pharmacological Sciences, 2003
: The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats.
Yoshihisa Kitamura   +4 more
doaj   +1 more source

The effect of imipramine on the behavior of albino mice in presence of selenium

open access: yesLibyan International Medical University Journal, 2016
Introduction: Imipramine, a tricyclic antidepressant used in the treatment of depression, anxiety, and other mental condition. Selenium is useful in managing depression and anxiety.
S Aburawi, S Baayo
doaj   +1 more source

Imipramine Accelerates Nonalcoholic Fatty Liver Disease, Renal Impairment, Diabetic Retinopathy, Insulin Resistance, and Urinary Chromium Loss in Obese Mice

open access: yesVeterinary Sciences, 2021
Imipramine is a tricyclic antidepressant that has been approved for treating depression and anxiety in patients and animals and that has relatively mild side effects.
Geng-Ruei Chang   +8 more
doaj   +1 more source

Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase receptor B signaling pathway

open access: yesNeural Regeneration Research, 2016
Retinal ganglion cell (RGC) degeneration is irreversible in glaucoma and tyrosine kinase receptor B (TrkB)-associated signaling pathways have been implicated in the process.
Ming-lei Han   +4 more
doaj   +1 more source

Chronic imipramine treatment-induced changes in acetylcholinesterase (EC 3.1.1.7) activity in discrete rat brain regions

open access: yesBrazilian Journal of Medical and Biological Research, 1997
Cholinergic as well as monoaminergic neurotransmission seems to be involved in the etiology of affective disorders. Chronic treatment with imipramine, a classical antidepressant drug, induces adaptive changes in monoaminergic neurotransmission.
R. Camarini, M.A.C. Benedito
doaj   +1 more source

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